A combination solution for routine pupillary dilation

Krumholz, David M.; Portello, Joan K.; Rosenfield, Mark; Rosenbaum, Jacob D.

doi:10.1016/j.optm.2006.04.107

Cited by 16 publications

(16 citation statements)

References 8 publications

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“…[6–9] All these studies aimed to find the optimal low concentrations of both drugs in the mixture that provided adequate pupil dilatation. The concentrations varied from 0.125 to 1.0% for tropicamide, and 1.25 to 5.0% for phenylephrine.…”

Section: Discussionmentioning

confidence: 99%

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Effective pupil dilatation with a mixture of 0.75% tropicamide and 2.5% phenylephrine: A randomized controlled trial

Trinavarat

Pituksung

2009

Indian J Ophthalmol

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Purpose:To compare the efficacy in pupil dilatation between a mixture containing 0.75% tropicamide and 2.5% phenylephrine and the alternate application of 1% tropicamide and 10% phenylephrine eye drops.Material and Methods:Patients requiring pupil dilatation were randomized to receive one drop of the mixture every 10 min for four times or our standard application of one drop of 1% tropicamide alternating with one drop of 10% phenylephrine every 10 min for two cycles. Pupil size was measured under bright light with the pupil gauge before, and every 5 min after initial application for 40 min. Application of the drops was discontinued once the pupil diameter reached 7 mm. Blood pressure and pulse rate were monitored every 15 min.Results:Of 40 patients (age 57.3±10.9 years, range 35-70 years), 22 were randomized into the mixture group and 18 into the alternate drug group. Baseline pupil sizes were 1.7±0.5 mm in the mixture group and 1.8±0.4 mm in the alternate drug group. The pupils were successfully dilated to 7 mm within 40 min in 17 patients of the mixture group compared to seven patients in the alternate drug group (P=0.004, Log Rank test). The mean pupil sizes at 40 min were 6.6±0.8 and 6.0±0.9 mm in the mixture and alternate drug groups respectively (P=0.050, t-test). Blood pressure and pulse rate were stable and similar in both groups.Conclusions:The mixture of 0.75% tropicamide and 2.5% phenylephrine is superior to our standard application of 1% tropicamide alternating with 10% phenylephrine. It provides faster and more successful pupil dilatation within 40 min.

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Section: Discussionmentioning

confidence: 99%

“…Krumholz et al showed equivalent effects of solutions containing 0.5% tropicamide with either 2.5% or 1.25% phenylephrine. [9] All pupils reached at least 7 mm in diameter within 30 min. However, this study was conducted in young subjects 21 to 40 (median 23) years of age.…”

Section: Discussionmentioning

confidence: 99%

Effective pupil dilatation with a mixture of 0.75% tropicamide and 2.5% phenylephrine: A randomized controlled trial

Trinavarat

Pituksung

2009

Indian J Ophthalmol

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“…[26][27][28][29] This review focuses on combinations of phenylephrine 2.5% to 10.0% with tropicamide 0.5% to 1.0% or cyclopentolate as these are the most thoroughly studied protocols. [29][30][31][32][33][34][35] Phenylephrine Phenylephrine is a synthetic sympathomimetic agent with a strong and selective affinity for a 1 -receptors. Topical application of phenylephrine to the eye causes dilation of the pupil and arteriolar vasoconstriction.…”

Section: Phenylephrine and Tropicamide Or Cyclopentolate Combination mentioning

confidence: 99%

“…44 Reduced concentrations of tropicamide and phenylephrine in combination (0.25% and 1.25%, respectively) can achieve sustained pupil dilation. 33 …”

Section: Combinationsmentioning

confidence: 99%

Mydriatic insert and intracameral injections compared with mydriatic eyedrops in cataract surgery: Controlled studies

Behndig¹,

Korobelnik²

2015

Journal of Cataract and Refractive Surgery

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“…More generally, mydriasis also refers to the natural dilation of pupils, for instance in low light conditions or under sympathetic stimulation. [3][4][5] There are two types of muscle that control the size of the iris: the iris sphincter, composed of circularly arranged muscle fibres, and the iris dilator, composed of radially arranged muscle fibres. The sphincter is innervated by (signalled by nerves of) the parasympathetic nervous system; the dilator by the sympathetic nervous system.…”

Section: Introductionmentioning

confidence: 99%

Efficacy Of Topical Tropicamide 1% Versus Combination Of Tropicamide 0.8% And Phenylephrine 5% For Mydriasis

P.A¹,

Pushpakaran²,

kurian³

2017

AIMDR

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Background: In ophthalmic practice, mydriasis is required on regular basis for refraction & Fundus examination. The study is done to compare effect of 1% tropicamide solution with a combination of 0.8% tropicamide and 5% phenylephrine, the rate of mydriasis and maximal mydriasis caused by a single drop of each solution, and to assess whether this mydriasis is resistant to bright light. Methods: In this prospective, randomized study, 150 patients who presented to the Department of Ophthalmology were evaluated for mydriasis. They received 1 drop of Tropicamide 1% in one eye and the combination drop in the other eye. The mydriasis was assessed at 15,30 and 45 minutes after instillation of the drops. Results: The fixed drug combination of 0.8% tropicamide with 5% phenylephrine was found to be a better mydriatic than 1% tropicamide alone, with a statistically significant difference between the two groups at 30 mins and 45 mins (p<0.001). Conclusion: A single drop of a combination of 0.8% tropicamide and 5% phenylephrine achieves adequate mydriasis, in patient 11-40 years of age.

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A combination solution for routine pupillary dilation

Cited by 16 publications

References 8 publications

Effective pupil dilatation with a mixture of 0.75% tropicamide and 2.5% phenylephrine: A randomized controlled trial

Effective pupil dilatation with a mixture of 0.75% tropicamide and 2.5% phenylephrine: A randomized controlled trial

Mydriatic insert and intracameral injections compared with mydriatic eyedrops in cataract surgery: Controlled studies

Efficacy Of Topical Tropicamide 1% Versus Combination Of Tropicamide 0.8% And Phenylephrine 5% For Mydriasis

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