A combination therapy of continuous superselective intraarterial carboplatin infusion and radiation therapy for locally advanced head and neck carcinoma

Fuwa, Nobukazu; Ito, Yoshiyuki; Matsumoto, Akira; Kamata, Minoru; Kodaira, T.; Furutani, Kazuhisa; Sasaoka, Masahiro; Kimura, Yasuo; Morita, Kozo

doi:10.1002/1097-0142(20001115)89:10<2099::aid-cncr10>3.3.co;2-w

Cited by 15 publications

(19 citation statements)

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“…As previously reported (Fuwa et al, 2000), the anterior ear on the affected side was incised under local anaesthesia to expose the superficial temporal artery. During fluoroscopy, a thin catheter was selectively inserted into the selected artery.…”

Section: Arterial Injection Therapymentioning

confidence: 99%

“…In 1992, we started chemoradiation therapy, in which continuous arterial infusion therapy with carboplatin was combined with radiotherapy, by selectively inserting a catheter into the target artery through the superficial temporal artery in patients with locally advanced head and neck cancer (Fuwa et al, 2000). We started therapy in two courses of systemic chemotherapy combined with intra-arterial chemoradiotherapy by continuous intra-arterial infusion of carboplatin and radiation therapy, in an effort to control metastasis in cervical lymph nodes and distant metastasis in 1997 (Fuwa et al, 2007).…”

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confidence: 99%

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Intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: analysis of therapeutic results in134 cases

et al. 2008

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The objective of this study was to investigate the therapeutic results of arterial injection therapy via the superficial temporal artery for 134 cases of stages III and IV (M0) oral cavity cancer retrospectively, and to clarify the prognostic factors. We administered intraarterial chemoradiotherapy by continuous infusion of carboplatin in 65 cases from January 1993 to July 2002. Systemic chemotherapy was performed on 26 cases at the same time. We administered intra-arterial chemoradiotherapy by cisplatin with sodium thiosulphate in 69 cases from October 2002 to December 2006. Systemic chemotherapy was performed on 48 cases at the same time. The 3-year local control rate was 68.6% (T2-3: 77.9%; T4: 51.3%), and the 3-year survival rate was 53.9% (stage III: 62.9%; stage IV: 45.3%). Regarding the results of multivariate analysis of survival rates, age (o65), selective intra-arterial infusion, and the use of cisplatin as an agent for intra-arterial infusion were significant factors. The therapeutic results of intra-arterial chemoradiotherapy via the superficial temporal artery were not inferior to the results of surgery. In particular, the results of arterial injection therapy by cisplatin with sodium thiosulphate were excellent, so we believe that it will be a new therapy for advanced oral cavity cancer.

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Section: Arterial Injection Therapymentioning

confidence: 99%

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confidence: 99%

Intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: analysis of therapeutic results in134 cases

et al. 2008

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“…Mainly, it was used in concurrent combination with radiation (Robbins et al, 1994;Shibuya et al, 1994;von Scheel et al, 1996;Fuwa et al, 2000;Furutani et al, 2002;Yamashita et al, 2002;Kitagawa et al, 2003) or alone (Nakasato et al, 2000). The drugs used mainly have been cisplatin or carboplatin.…”

mentioning

confidence: 99%

“…The drugs used mainly have been cisplatin or carboplatin. Administration was either continuously over a temporal retrograde approach (Fuwa et al, 2000;Nakasato et al, 2000;Furutani et al, 2002) or by repeated bolus infusions over a transfemoral anterograde approach (Robbins et al, 1994). The temporal approach had the general disadvantage of not being selective or superselective.…”

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confidence: 99%

Intra-arterial induction high-dose chemotherapy with cisplatin for oral and oropharyngeal cancer: long-term results

Kovács

2004

Br J Cancer

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Intra-arterial (IA) chemotherapy for curative treatment of head and neck cancer experienced a revival in the last decade. Mainly, it was used in concurrent combination with radiation in organ-preserving settings. The modern method of transfemoral approach for catheterisation, superselective perfusion of the tumour-feeding vessel, and high-dose (150 mg m À2 ) administration of cisplatin with parallel systemic neutralisation with sodium thiosulphate (9 g m À2 ) made preoperative usage feasible. The present paper presents the results of a pilot study on a population of 52 patients with resectable stage 1 -4 carcinomas of the oral cavity and the oropharynx, who were treated with one cycle of preoperative IA chemotherapy executed as mentioned above and radical surgery. There have been no interventional complications of IA chemotherapy, and acute side effects have been low. One tracheotomy had to be carried out due to swelling. The overall clinical local response has been 69%. There was no interference with surgery, which was carried out 3 -4 weeks later. Pathological complete remission was assessed in 25%. The mean observation time was 3 years. A 3-year overall and disease-free survival was 82 and 69%, respectively, and at 5 years 77 and 59%, respectively. Survival results were compared to a treatment-dependent prognosis index for the same population. As a conclusion, it can be stated that IA high-dose chemotherapy with cisplatin and systemic neutralisation in a neoadjuvant setting should be considered a feasible, safe, and effective treatment modality for resectable oral and oropharyngeal cancer. The low toxicity of this local chemotherapy recommends usage especially in stage 1 -2 patients. The potential of survival benefit as indicated by the comparison to the prognosis index should be controlled in a randomised study.

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“…The knowledge of such arterial variation is useful during intra-arterial chemotherapy for the treatment of tongue cancers, musculomucosal island flap for partial tongue reconstruction, superselective intraarterial chemotherapy for head and neck carcinomas, these variations should be kept in mind [5,8,[12][13][14]. Zumre et al [5] observed thyrolingual trunk in 2.5% and thyrolinguofacial trunk in 2.5% of the cases in human foetuses.…”

Section: Discussionmentioning

confidence: 99%

Study of Thyro-Lingual Trunk and its Clinical Relevance

Kapre¹,

Mangalgiri

Mahore

2011

Indian J Otolaryngol Head Neck Surg

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Every surgery is planned on the anatomical arrangement of the structures. Any variation in the arterial arrangement may lead to haemorrhagic episodes during intraoperative procedures. In this study, variations in the branching pattern of external carotid artery were noted. In two of the cases, thyrolingual trunk was observed. In the first case, thyrolingual trunk was arising from the common carotid artery, 17 mm below carotid bifurcation and in the second one at the carotid bifurcation. The knowledge of anatomical variation is necessary during intra-arterial chemotherapy and to prevent haemorrhagic accidents during intraoperative procedures.

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A combination therapy of continuous superselective intraarterial carboplatin infusion and radiation therapy for locally advanced head and neck carcinoma

Cited by 15 publications

References 0 publications

Intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: analysis of therapeutic results in134 cases

Intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: analysis of therapeutic results in134 cases

Intra-arterial induction high-dose chemotherapy with cisplatin for oral and oropharyngeal cancer: long-term results

Study of Thyro-Lingual Trunk and its Clinical Relevance

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