A Combined Study on the Use of the Child Behavior Checklist 1½–5 for Identifying Autism Spectrum Disorders at 18 Months

Chericoni, Natasha; Balboni, Giulia; Costanzo, Valeria; Mancini, Alice; Prosperi, Margherita; Lasala, Roberta; Tancredi, Raffaella; Scattoni, María Luisa; Molteni, Massimo; Valeri, Giovanni; Vicari, Stefano; Zoccante, Leonardo; Arduino, Maurizio; Venuti, Paola; Sogos, Carla; Guzzetta, Andrea; Muratori, Filippo; Apicella, Fabio

doi:10.1007/s10803-020-04838-0

Cited by 10 publications

(7 citation statements)

References 56 publications

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“…In this cohort, CBCL-ASP predicted subsequent doctor-diagnosed autism with an area under the curve (AUC) of 0.92. 54 In the literature, the CBCL/1.5-5 pervasive developmental problems scale (CBCL-PDP), SDQ-peer and SDQ-prosocial have moderate to high accuracy in distinguishing preschoolers with ASD from those who are typically developing (AUC 0.92 55 , 0.82 and 0.77 56 ), respectively. CBCL-ASP has replaced CBCL-PDP to reflect changes in the DSM-5.…”

Section: Methodsmentioning

confidence: 99%

Increased maternal non-oxidative energy metabolism mediates association between prenatal DEHP exposure and offspring ASD symptoms: a birth cohort study

Thomson

Drummond

O’Hely

et al. 2022

Preprint

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Prenatal phthalate exposure has previously been linked to the development of autism spectrum disorder (ASD). However, the underlying biological mechanisms remain unclear. We investigated whether maternal and child central carbon metabolism is involved as part of the Barwon Infant Study, a population-based birth cohort of 1074 Australian children. We estimated phthalate daily intakes using third-trimester urinary phthalate metabolite concentrations and other relevant indices. The metabolome of maternal serum in the third trimester, cord blood at birth and child plasma at 1 year were measured by nuclear magnetic resonance. We used the Small Molecule Pathway Database and principal component analysis to construct composite metabolite scores reflecting metabolic pathways. ASD symptoms at 2 and 4 years were measured by subscales of the Child Behavior Checklist and the Strengths and Difficulties Questionnaire, respectively. Multivariable linear regression analyses demonstrated (i) associations between higher prenatal di(2-ethylhexyl) phthalate (DEHP) levels and increased activity in maternal non-oxidative energy metabolism pathways, specifically non-oxidative pyruvate metabolism and the Warburg Effect, and (ii) associations between increased activity in these pathways and increased offspring ASD symptomology at 2 and 4 years of age. Mediation analyses suggested that part of the mechanism by which higher prenatal DEHP exposure influences the development of ASD symptoms in early childhood is through a maternal metabolic shift in pregnancy towards non-oxidative energy pathways, which are inefficient compared to oxidative metabolism. Interventions targeting maternal metabolic activity in pregnancy may be beneficial in reducing the potential risk to the developing fetus.

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Section: Methodsmentioning

confidence: 99%

Increased maternal non-oxidative energy metabolism mediates association between prenatal DEHP exposure and offspring ASD symptoms: a birth cohort study

Thomson

Drummond

O’Hely

et al. 2022

Preprint

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show abstract

“…In this study, we focused on the Withdrawn Syndrome scale and the Pervasive Developmental Problems (PDP) scale, based on previous literature showing good sensitivity and specificity in differentiating ASD children and controls [ 35 , 36 ]. Thus, Withdrawn and PDP T-scores (mean = 50; SD = 10) were entered in the analyses, and higher scores indicate greater problems.…”

Section: Methodsmentioning

confidence: 99%

A Pilot Study Evaluating the Effects of Early Intervention for Italian Siblings of Children with Autism Spectrum Disorder

et al. 2021

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Autism spectrum disorder (ASD) is a high-cost/high-burden problem. Early intervention may prevent development of the disorder, improving child outcomes and reducing long-term consequences. However, few studies have investigated the role of early intervention in children younger than two years. This study aims to examine the effect of early intervention in 18-month-old high-risk siblings of children with ASD (HR-ASD) with clinical signs of autism. The intervention is based on the principles of Applied Behavior Analysis and focuses on the development of early precursors to social and communicative competence (joint attention and imitation behaviors). After controlling for baseline differences, two comparison HR-ASD groups were included: 15 HR-ASD toddlers receiving behavioral intervention for 3 h per week for 5 months (INT+) and 15 HR-ASD toddlers who were only clinically monitored from age 18 months (INT−). Changes in social communication, restricted/repetitive behaviors, and language were assessed using standardized measures at pre- (T0) and post-intervention (T1). From T0 to T1, the INT+ group showed significant improvements in communication, social interaction, and language compared to INT− group. There was no effect on restricted/repetitive behaviors. Our findings highlighted the importance of early detection/intervention in autism and supported a positive impact of targeted interventions to improve outcomes in at-risk children.

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“…The child behavior checklist (CBCL) is one of the screening scales for assessing children's emotional and behavioral problems and is widely used to assess, collect, and rate children's internalizing and externalizing behavioral problems [ 18 , 19 ]. The Autism Behavior Checklist (ABC) is a 57-item scale commonly used in clinic to characterize the behavior of children aiming to screen and diagnose ASD [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of salivary steroid hormones in boys with autism spectrum disorder

Wang²,

Liu

et al. 2023

BMC Psychiatry

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Background Autism spectrum disorders (ASD) is a neurodevelopmental disorder with high incidence rate and difficult diagnosis. The purpose of this study was to explore whether salivary cortisol, dehydroepiandrosterone (DHEA) and pregnenolone can be used as biomarkers of ASD children. Methods The saliva samples of 55 boys with ASD were collected as the experimental group, and the saliva samples of 24 neurotypical boys were collected as the control group. The Child Behavior Checklist (CBCL), Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS), Repetitive Behavior Scale (RBS) were used to assess the severity of symptoms in boys with ASD. Cortisol, DHEA and pregnenolone concentrations in saliva were measured using an ABSSCIEX QTRAP® 6500 + LC/MS/MS system. SPSS 23.0 was used for statistical analysis. Comparisons between the two groups which conform to normal distribution were performed by T-test, and those which don’t conform to normal distribution were performed by Mann–Whitney U test. Correlation analysis between two variables was performed using Spearman's correlation analysis. Receiver operating characteristic curve (ROC) analysis was performed to evaluate the discriminatory sensitivity of each hormone between ASD and normal control groups. Logistic regression models were used to analyze whether DHEA and salivary pregnenolone can be used as a biomarker of ASD. Results There were no significant differences in age, and weight between the ASD group and the normal control group. The ABC, SRS, RBS and CBCL scale scores in the ASD group were significantly higher than those in the normal control group. The salivary DHEA and pregnenolone concentrations in the ASD group were significantly higher than those in the normal control group, but there was no significant difference in cortisol. Spearman's correlation analysis showed that only pregnenolone associated with ABC. Logistic regression model analysis suggested that pregnenolone in saliva was an independent predictor of ASD. ROC analysis found that pregnenolone had good discrimination sensitivity between ASD and normal controls. Conclusion Gave salivary preoperative a space for utilization as biomarker as number of cases are limited to this high expectation.

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A Combined Study on the Use of the Child Behavior Checklist 1½–5 for Identifying Autism Spectrum Disorders at 18 Months

Cited by 10 publications

References 56 publications

Increased maternal non-oxidative energy metabolism mediates association between prenatal DEHP exposure and offspring ASD symptoms: a birth cohort study

Increased maternal non-oxidative energy metabolism mediates association between prenatal DEHP exposure and offspring ASD symptoms: a birth cohort study

A Pilot Study Evaluating the Effects of Early Intervention for Italian Siblings of Children with Autism Spectrum Disorder

Analysis of salivary steroid hormones in boys with autism spectrum disorder

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