A common neuronal mechanism of hypertension and sleep disturbances in spontaneously hypertensive rats: Role of orexinergic neurons

Cui, Shuzhen; Huang, Yuan‐Li; Cui, Xiang‐Yu; Zhao, Hang; Hu, Xiao; Liu, Yu‐Tong; Qin, Yu; Kurban, Nurhumar; Zhang, Yonghe

doi:10.1016/j.pnpbp.2020.109902

Cited by 4 publications

(3 citation statements)

References 50 publications

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“…All images of each section were acquired at 20× magnification. The number of MCH-positive neurons in each mm 2 LH area was evaluated according to our common protocol ( Cui et al, 2020 ). At least 3 serial sections of the LH were used to analyze the data for each rat.…”

Section: Methodsmentioning

confidence: 99%

Chronic Stress-Induced Elevation of Melanin-Concentrating Hormone in the Locus Coeruleus Inhibits Norepinephrine Production and Associated With Depression-Like Behaviors in Rats

Kurban,

Qin,

Zhao

et al. 2023

International Journal of Neuropsychopharmacology

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Background Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide that projects throughout the central nervous system, including the noradrenergic locus coeruleus (LC). Our previous study suggested that MCH/MCH receptor 1 (MCHR1) in the LC may be involved in the regulation of depression. The present study investigated whether the role of MCH/MCHR1 in the LC in depression-like behaviors is associated with the regulation of norepinephrine. Method Chronic unpredictable stress (CUS) and an acute intra-LC microinjection of MCH induced depression-like behaviors in rats. The MCHR1 antagonist SNAP-94847 was also microinjected in the LC in rats that were suffered CUS or treated with MCH. The sucrose preference, forced swim, and locomotor tests were used for behavioral evaluation. Immunofluorescence staining, ELISA, western blot and HPLC-ECD were used to explore the mechanism of MCH/MCHR1 in the regulation of depression-like behaviors. Results CUS induced an abnormal elevation of MCH levels and downregulated MCHR1 in the LC, which was highly correlated with the formation of depression-like behaviors. SNAP-94847 exerted antidepressant effects in CUS-exposed rats by normalizing tyrosine hydroxylase, dopamine β hydroxylase, and norepinephrine in the LC. An acute microinjection of MCH induced depression-like behaviors through its action on MCHR1. MCHR1 antagonism in the LC significantly reversed the MCH-induced downregulation of norepinephrine production by normalizing MCHR1-medicated cAMP-PKA signaling. Conclusions Our study confirmed that the MCH/MCHR1 system in the LC may be involved in depression-like behaviors by downregulating norepinephrine production. These results improve our understanding of the pathogenesis of depression that is related to the MCH/MCHR1 system in the LC.

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Section: Methodsmentioning

confidence: 99%

Chronic Stress-Induced Elevation of Melanin-Concentrating Hormone in the Locus Coeruleus Inhibits Norepinephrine Production and Associated With Depression-Like Behaviors in Rats

Kurban,

Qin,

Zhao

et al. 2023

International Journal of Neuropsychopharmacology

Self Cite

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“…In the early stage of hypertension, the whole body is characterized by small artery spasm. Long-term high blood pressure causes arteriosclerosis, subintimal hyaline degeneration, and proliferation or hypertrophy of middle smooth muscle cells, resulting in wall thickening and lumen stenosis, accompanied by the decline of vascular function, maintaining and developing high blood pressure, and further leading to ischemic injury of important target organs, such as heart, brain, and kidney [15] …”

Section: Introductionmentioning

confidence: 99%

“…Long-term high blood pressure causes arteriosclerosis, subintimal hyaline degeneration, and proliferation or hypertrophy of middle smooth muscle cells, resulting in wall thickening and lumen stenosis, accompanied by the decline of vascular function, maintaining and developing high blood pressure, and further leading to ischemic injury of important target organs, such as heart, brain, and kidney. [15] Studies have shown that every 20 mm Hg rise in systolic blood pressure or 10 mm Hg rise in diastolic blood pressure will significantly increase the risk of cardiovascular disease. [16] The revised version of Chinese guidelines for the prevention and treatment of hypertension in 2018 clearly points out that the fundamental goal of hypertension is to reduce the total risk of cardiovascular, cerebrovascular, renal, and vascular complications as well as death.…”

Section: Introductionmentioning

confidence: 99%

Acupuncture combined with western medicine for the treatment of hypertension

Wang¹,

Xu²,

et al. 2021

Medicine

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Background: Hypertension is a kind of cardiovascular syndrome with the main clinical manifestation of continuous increase of systemic arterial blood pressure. Hypertension coexists with other cardiovascular risk factors and is an important risk factor for cardiovascular and cerebrovascular diseases. Acupuncture is an important part of Traditional Chinese Medicine intervention. The antihypertensive effect of acupuncture on hypertension is based on the neuroendocrine system, characterized by multichannel and multitarget. This study aims to provide latest and updated proof of systematic review to assess the effectiveness and safety of acupuncture for hypertension. Methods: We will systematically search 9 databases from their inceptions to February 2021. Only randomized controlled trials of acupuncture combined with western medicine in the treatment of hypertension will meet the inclusion criteria. The main outcome measures we focus on include clinical efficacy, syndrome efficacy, Traditional Chinese Medicine syndrome score, diastolic and systolic blood pressure changes, blood pressure variability, heart rate variability, pulse rate variability, and adverse reactions. The research screening, data extraction, and risk of bias assessment will be employed by 2 reviewers independently, and disagreement will be decided by a third senior reviewer. The Revman 5.3 software will be used for meta-analysis. The confidence of proof will be rated adopting grading of recommendations assessment, development and evaluation tool and methodological quality of this research will be assessed using assessment of multiple systematic reviews-2 and risk of bias in systematic reviews. The publication quality will be evaluated by preferred reporting items for systematic reviews and meta-analyses (PRISMA). Results: This systematic review (SR) will provide evidence-based medical evidence for hypertension therapy by acupuncture combined with western medicine and we will submit the findings of this SR for peer-review publication. Conclusions: This SR will provide latest and updated summary proof for assessing the effectiveness and safety of acupuncture for hypertension. Registration number: INPLASY 202150047

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Roles of central orexinergic system on cardiovascular function and acupuncture on intervention of cardiovascular risk: Orexinergic system mediate the role of acupuncture?

Gao

et al. 2021

Neuropeptides

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A common neuronal mechanism of hypertension and sleep disturbances in spontaneously hypertensive rats: Role of orexinergic neurons

Cited by 4 publications

References 50 publications

Chronic Stress-Induced Elevation of Melanin-Concentrating Hormone in the Locus Coeruleus Inhibits Norepinephrine Production and Associated With Depression-Like Behaviors in Rats

Chronic Stress-Induced Elevation of Melanin-Concentrating Hormone in the Locus Coeruleus Inhibits Norepinephrine Production and Associated With Depression-Like Behaviors in Rats

Acupuncture combined with western medicine for the treatment of hypertension

Roles of central orexinergic system on cardiovascular function and acupuncture on intervention of cardiovascular risk: Orexinergic system mediate the role of acupuncture?

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