A common pathway for chemical-induced tissue injury and immune responses leading to hypersensitivity and/or carcinogenesis

Weliky, Norman; Heiner, Douglas C.

doi:10.1016/0306-9877(85)90041-6

Cited by 3 publications

(1 citation statement)

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“…Chung [42,44] also emphasizes that the azo dyes can be reduced to aromatic amines by the intestinal microflora. According to the Brazilian Society of Urology, around 20% of the bladder cancer cases are associated to the occupational exposure to aromatic amines, which are also present in the smoke of cigarettes and its metabolites excreted in the urine of smokers are responsible for about 50% of the bladder cancer cases [45]. For Weliky and Heiner [4], a common requisite for the chemically induced allergy and carcinogenesis in the liver is the capacity of the product in reacting to form covalent conjugates, as occurs with the aromatic amines, the propensity of an individual to convert normally innocuous chemical products to form reactive forms under the physiological conditions, can proportionate an indicator of risk of developing cancer.…”

Section: Figure 2 Average Quantity Of Mg/100g Of Twilight Yellow (Fcmentioning

confidence: 99%

Colorful, Cute, Attractive and Carcinogenic: The Dangers of Dyes

Almeida¹

2014

CRJ

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Azo dyes and their derivatives have been linked to cases of bladder, prostate, esophagus, rectum, stomach and ovary cancer. These dyes are quite common on food, however, several countries have revised its use and reassessed what are the acceptable concentrations of these pigments. Twilight Yellow and Tartrazine are two azo dyes allowed on food in many countries around the world, they are used for the preparation of gelatins, cake, juices, ready soft drinks, candies, chewing gum, snacks, crackers and etc. Among children and adolescents, the consumption of these foods is common, which can lead to high dye levels in the body. This study examined the concentration of Twilight Yellow and Tartrazine dyes in food consumed by children in Brazilian schools. The results indicated that high consumption of sweets tends to exceed the acceptable daily intake of dyes. Moreover, many products have levels above the allowed by the Brazilian legislation, which increases the risk of cancer.

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Section: Figure 2 Average Quantity Of Mg/100g Of Twilight Yellow (Fcmentioning

confidence: 99%