Cell-mediated immunity and head and neck cancer: With special emphasis on betel quid chewing habit

Chang, Mei‐Chi; Chiang, Chun-Pin; Lin, Chungwei; Lee, Jang‐Jaer; Hahn, Liang‐Jiunn; Jeng, Jiiang‐Huei

doi:10.1016/j.oraloncology.2005.01.007

Cited by 90 publications

(66 citation statements)

References 136 publications

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“…This would accord with tobacco chewing being associated with higher risks of oral than pharyngeal cancers (Dikshit and Kanhere, 2000), the former effect being stronger in females (Balaram et al, 2002). A substantial limitation of the Health Survey is its not covering the use of betel alone, a well-established carcinogen (Chang et al, 2005); its use is common in some South Asian (and other) minority ethnic groups (Bedi and Gilthorpe, 1995).…”

Section: Discussionmentioning

confidence: 99%

Oral and pharyngeal cancer in South Asians and non-South Asians in relation to socioeconomic deprivation in South East England

et al. 2008

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From UK Thames Cancer Registry data, after controlling for socioeconomic deprivation of area of residence, South Asian males showed a higher relative risk of oral (1.36; 95% CI: 1.11, 1.67), but not of pharyngeal cancer than non-South Asian males, whereas South Asian females had much higher risks of these cancers (3.67; 95% CI: 2.97, 4.53 and 2.06; 95% CI: 1.44, 2.93), respectively, than non-South Asians.

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Section: Discussionmentioning

confidence: 99%

Oral and pharyngeal cancer in South Asians and non-South Asians in relation to socioeconomic deprivation in South East England

et al. 2008

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“…There are 4600 million AQ chewers in the world, mostly in Southeast Asia (Gupta & Warnakulasuriya, 2002). AQ chewing is a major risk factor for oral cancers and pre-cancer lesions (Coppola & Mondola, 2012), whose pathophysiology has been shown to be associated with immune deterioration, including alterations of T-cell immunity (Chang et al, 2005). Epidemiological evidence suggests that, in certain cultures, children may start AQ chewing before age 10 and pre-natal exposure to areca ingredients may exist due to the continuing chewing habit in the pregnant female population (Farrand et al, 2001;Shah et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Impairment of thymocyte function via induction of apoptosis by areca nut extract

Lee

Lin

Liu

et al. 2013

Journal of Immunotoxicology

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Areca quid (AQ) chewing is a popular oral habit, especially in Southeast Asia cultures, in which children may be engaged in the addictive habit early in their lives. Extracts of areca nuts, the main component of AQ, have been shown to affect the functionality of T-cells. However, the potential influence of ANE on the development of T-cells is unknown. This study, therefore, investigated the impact of areca nut extracts (ANE) on thymocytes and the potential mechanisms of action. Mice administered intraperitoneally with ANE at 1, 5, or 25 mg/kg daily for 5 days showed significant dose-dependent reductions in thymocyte viability. A marked decrease in the total number of thymocytes and the proportion of thymic CD4 þ CD8þ cells was observed in the 25 mg ANE/kg-treated mice, whereas the proportion of CD4 and CD8 single positive and CD4À CD8 À cells was significantly increased. Further examination on the functionality of thymocytes showed that ANE suppress IL-2 production both ex vivo and in vitro. These results suggest that ANE may attenuate the development and functionality of thymic T-cells. ANE also directly induced apoptosis in thymic T-cells through activation of casapase-3 and apoptosis inducing factor (AIF). Collectively, the data suggested that the thymus is a sensitive target to ANE. Early exposure to ANE may interfere with the development and functionality of thymic T-cells.

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“…Moreover, these lymphocytes may be responsible for the increase in the expression of MHC-I by tumor cells, resulting in the sensitization of CD8 T lymphocytes and consequent lysis of the tumor cells by the perforin/ granzyme system or through the bonding of Fas in the tumor cells with Fas-L (CD95) from the lymphocytes. Therefore, the suppression of CD4 Th1 lymphocytes has been shown to result in tumor progression (12). However, the immunosuppressive property of CD4 T cells was associated with a low survival rate among patients with ovarian cancer (13).…”

Section: Introductionmentioning

confidence: 99%

Role of inflammation in oral carcinogenesis (Part I): Histological grading of malignancy using a binary system

Piva¹,

Souza²,

Martins-Filho³

et al. 2011

Oncology Letters

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Abstract. The aim of the present study was to assess the suppressant role of the inflammatory infiltrate in oral carcinogenesis through the immunohistochemical expression of CD8 and FOXP3 and to discuss how representative this expression proved, as well as other parameters considered to be of prognostic value. A total of 20 cases of oral epithelial dysplasia and 40 cases of oral squamous cell carcinoma were selected. The criteria suggested by the World Health Organization were used for the histological grading of dysplasia. For carcinoma, a binary method was developed for the present study using parameters such as type of invasion, maturity, presence of epithelial masses and dysmorphism of the masses. Immunohistochemical analysis was performed for assessment of the expression of anti-CD8 and anti-FOXP3 in cases of dysplasia and carcinoma. Although the inflammatory infiltrate was more intense in the majority of carcinomas, it exercised a protective role in the dysplasia cases, as CD8 expression was significantly greater. Although a correlation was found between CD8 and the intensity of the inflammatory infiltrate in the carcinoma cases, CD8 demonstrated >5% expression in only 32.5% of the cases, compared to 80% of the dysplasia cases. Thus, we suggest that the inflammatory infiltrate should not be used as a parameter in routine examinations, as it plays different roles in the various stages of carcinogenesis. The histological grading system for malignancy employed in the present study is indicated for the assessment of oral squamous cell carcinoma.

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Cell-mediated immunity and head and neck cancer: With special emphasis on betel quid chewing habit

Cited by 90 publications

References 136 publications

Oral and pharyngeal cancer in South Asians and non-South Asians in relation to socioeconomic deprivation in South East England

Oral and pharyngeal cancer in South Asians and non-South Asians in relation to socioeconomic deprivation in South East England

Impairment of thymocyte function via induction of apoptosis by areca nut extract

Role of inflammation in oral carcinogenesis (Part I): Histological grading of malignancy using a binary system

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