A Community-based Physical Activity Program for Adolescents With Cancer (Project TREK)

Keats, Melanie R.; Culos-Reed, S Nicole

doi:10.1097/mph.0b013e318162c476

Cited by 113 publications

(227 citation statements)

References 40 publications

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“…69 However, a recent community-based intervention showed improvements in QOL in adolescents surviving cancer. 43 In contrast, the intrahospital intervention of San Juan et al 71 showed no effect on QOL. As with other outcomes, limited supervision interventions, such as that of Takken et al 47 , did not show any improvement in fatigue.…”

Section: Adultsmentioning

confidence: 66%

“…A recent community-based intervention showed improvements in physical activity levels and physical fitness in adolescents surviving cancer, though they returned to low physical activity levels shortly after they finished the program. 43 Intrahospital, individually supervised training programs also appear beneficial for young ALL survivors. San Juan et al 71 reported that a 16-week combined aerobic and resistance training intervention of thrice weekly activity for 90-120 min significantly improved aerobic fitness in very young (4-7 years) pediatric ALL survivors in maintenance treatment phase.…”

Section: Adultsmentioning

confidence: 99%

“…Twelve studies, [42][43][44][45][46][47][48][68][69][70][71][72] including two RCT 42,44 and seven high-quality studies [42][43][44][45][46]69,71 evaluated the effects of physical activity interventions on outcomes in children with pediatric cancer who did not undergo HSCT. One study of high quality 68 evaluated the effects of a single (30 min) exercise bout.…”

Section: Adultsmentioning

confidence: 99%

“…Liu et al 33 recently performed a systematic review on exercise interventions conducted in hematological cancer patients, including studies published up to September 2007. This area of research is growing considerably and several intervention studies in adult/children survivors of hematological cancer have been recently published in adults [34][35][36][37][38][39][40] and in children 28,[41][42][43][44][45][46][47] that were not included in the review by Liu et al 33 Here, we summarize the intervention data related to all the possible effects of physical activity on adult and pediatric hematological cancer survivors. The information is also detailed extensively in Supplementary Material.…”

Section: Introductionmentioning

confidence: 99%

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Exercise in adult and pediatric hematological cancer survivors: an intervention review

et al. 2010

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Observational research has shown that the physical activity levels of survivors of hematological cancer are low, with deleterious health consequences. This review summarizes the research on exercise interventions in adult and pediatric hematological cancer survivors. We searched MEDLINE, SPORTDiscus, CINAHL, Embase, Cochrane and PEDro through September 2009 for exercise intervention studies in children and adults with any type of hematological cancer. In the 24 adult intervention studies reviewed, we found strong evidence (that is, X3 high-quality studies and X75% reporting a significant benefit) for a benefit on body composition. Weak, but promising, evidence (X3 high-quality studies, but o75% reporting a significant benefit) was found for cardiorespiratory fitness, fatigue, muscle strength, physical functioning and quality of life. In pediatric interventions (13 studies), we found strong evidence for a benefit on muscle strength and cardiorespiratory fitness, particularly, if training was conducted in the hospital setting. Evidence is weak for ankle dorsiflexion, physical functioning and body composition. No exerciserelated risks were identified in adults or children studies. Though more randomized controlled trials are needed, a growing body of literature supports the notion that regular physical activity is safe and has potential benefits for both adult and pediatric hematological cancer survivors.

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Section: Adultsmentioning

confidence: 66%

Section: Adultsmentioning

confidence: 99%

Section: Adultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Exercise in adult and pediatric hematological cancer survivors: an intervention review

et al. 2010

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“…As a result of the numerous LAE related to pediatric cancer treatment, an interest in using exercise as a therapeutic measure to attenuate or reverse many cancer-related LAE in the pediatric population has surfaced. While comparatively less studied, the research suggests that there is a positive effect of physical activity on organ system function, fatigue, and physical well-being in children during and after cancer treatment [39][40][41][42][43][44][45][46][47][48][49]. It is clear that children who exercise can increase aerobic fitness and strength, with the latter a result of neuromuscular adaptations rather than skeletal muscle hypertrophy.…”

Section: Introductionmentioning

confidence: 99%

The Role of Exercise in Pediatric and Adolescent Cancers: A Review of Assessments and Suggestions for Clinical Implementation

Klika

Tamburini

Galanti

et al. 2018

JFMK

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Abstract:In the European Union, five-year survival rates for childhood cancer patients are approaching 72-80%, which is a testament to better diagnostics and improved treatment. As a result, a large proportion of childhood cancer patients go on to live productive lives well past reproductive age. While this is encouraging, childhood cancer treatment is accompanied by multiple long-term adverse effects on physical and mental wellbeing. While there are several approaches to address mental health, reproductive integrity, secondary pathologies, and recurrence, in order to optimize quality of life in childhood cancer patients, exercise and nutrition should also be considered. It is clear that physical activity plays an important role in the prevention and reduction of long-term adverse side effects associated with cancer treatment in both children and adults. However, the current exercise guidelines for cancer survivors are based on adult data and accordingly are not appropriate for children. As children and adults are markedly different, including both the pathophysiology of cancer and exercise response, treatment plans incorporating exercise for children should be age-specific and individually tailored to both reduce the development of future comorbidities and enhance physical health. The purpose of this paper is to review the predominant cancer types and effects of cancer treatment in children, describe several special considerations, and propose a framework for assessment and exercise guidelines for this population.

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Skeletal muscle and childhood cancer: Where are we now and where we go from here

2021

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Skeletal muscle (muscle) is essential for physical health and for metabolic integrity, with sarcopenia (progressive muscle mass loss and weakness), a precursor of aging and chronic disease. Loss of lean mass and muscle quality (force generation per unit of muscle) in the general population are associated with fatigue, weakness, and slowed walking speed, eventually interfering with the ability to maintain physical independence, and impacting participation in social roles and quality of life. Muscle mass and strength impairments are also documented during childhood cancer treatment, which often persist into adult survivorship, and contribute to an aging phenotype in this vulnerable population.Although several treatment exposures appear to confer increased risk for loss of mass and strength that persists after therapy, the pathophysiology responsible for poor muscle quantity and quality is not well understood in the childhood cancer survivor population. This is partly due to limited access to both pediatric and adult survivor muscle tissue samples, and to difficulties surrounding noninvasive investigative approaches for muscle assessment. Because muscle accounts for just under half of the body's mass and is essential for movement, metabolism, and metabolic health, understanding mechanisms of injury responsible for both initial and persistent dysfunction is important and will provide a foundation for intervention. The purpose of this review is to provide an overview of the available evidence describing associations between childhood cancer, its treatment, and muscle outcomes, identifying gaps in current knowledge. K E Y W O R D Schildhood cancer, muscle fitness, muscle health, muscle mass, muscle outcomes, muscle quality, skeletal muscle INTRODUCTIONIncreased survival rates for childhood cancer are a direct reflection of major therapeutic and diagnostic advancesThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A Community-based Physical Activity Program for Adolescents With Cancer (Project TREK)

Cited by 113 publications

References 40 publications

Exercise in adult and pediatric hematological cancer survivors: an intervention review

Exercise in adult and pediatric hematological cancer survivors: an intervention review

The Role of Exercise in Pediatric and Adolescent Cancers: A Review of Assessments and Suggestions for Clinical Implementation

Skeletal muscle and childhood cancer: Where are we now and where we go from here

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