A compact and novel semi-elliptical defected ground structure (SE-DGS) tapered microstrip line fed UWB antenna with band notched characteristics integrated with Ku and K band applications is proposed. The proposed SE-DGS UWB antenna is printed on a compact size of (15×18 mm2) and has an impedance bandwidth of 4.11-29.77 GHz, a fractional bandwidth of 152%, and both the down link of X- and ITU-8 bands are completely notched over a span of 6.86-9.09 GHz using a single C-structured reflector. The proposed antenna has a fluctuating gain of 1.7–4.82 dBi except for the gain at the notched band frequency, which is -12.25 dBi. The proposed antenna has a high radiation efficiency of 96.23%, stable radiation patterns over the UWB range, and a high rejection capability of the notched band, which is noticed from the high value of VSWR of 23.15, making it a potential candidate for UWB, Ku, and K band wireless applications with effectively suppressed downlink of X and ITU-8 bands. The developed antenna design simulates breast cancer tissue detection by comparing S21 outcomes, current densities, and specific absorption rates with and without tumour scenarios. These results suggest that the proposed radiator and system detect breast tumours efficiently.