A Compact Half-Bridge Induction Heating System for Magnetic Nanoparticle Thermotherapy Applications

Abstract

Appling magnetic nanoparticle (MNP) in curing cancers has been a significant subject of medical research. A variety of switched-mode resonant inverters using voltage-fed-type high-frequency applicator with power MOSFET (metal oxide semiconductor field effect transistor) gate has been recently developed for medical use in electromagnetic thermotherapy. In this paper, a MNP heating system is presented and the electrical circuit characteristics of resonant components are analyzed. A half-bridge induction heating incorporate component functions directly at the applicator thereby reducing the size, weight, and cost of MNP heating systems. Preliminary heating results show a rise of about 3.8°C with 10-nm MNP for a 220-kHz frequency during the first 20 min.

Induction Heating Technology and Its Applications: Past Developments, Current Technology, and Future Challenges

“…Modern research trends investigate about the use of fluids with ferromagnetic nanoparticles in order to obtain precise heat distributions [93][94][95][96][97]. These techniques require the design of accurate power converters and control [90][91][92], and specific inductor designs [3], [98]. Due to the typical low resistivity nature of IH loads for medical applications, parallel resonant inverters are applied in order to minimize the current through the inverter.…”

The fabrication and characterization of dicalcium phosphate dihydrate-modified magnetic nanoparticles and their performance in hyperthermia processes in vitro

“…Magnetic nanoparticles are being increasingly considered for hyperthermia cancer therapy because of the relatively lower number of side effects associated with them [1][2][3]. Iron oxide (maghemite g-Fe 2 O 3 or magnetite Fe 3 O 4 ) is frequently used in clinical or experimental settings of biotechnology [4].…”