A Comparative Analysis and Systematic Review of the Wound-Healing Milieu: Implications for Body Contouring after Massive Weight Loss

Abstract

Complications after body contouring surgery are likely multifactorial; however, molecular imbalances to the massive weight loss wound milieu may contribute to poor surgical outcomes. Examining wound regulatory proteins including transforming growth factor-beta, vascular endothelial growth factor, and matrix metalloproteinases could aid in understanding the healing difficulties observed clinically.

Dynamic changes of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 after burn injury

“…In a meta-analysis of 3 studies, 1.4-fold increase of serum TIMP-1 levels was found after burn injury [19]. Patients with extended hypertrophic scars after burn trauma presented a significantly higher TIMP-1 concentration in their sera than the other patients.…”

Wound healing and scar formation

“…26 Plastic surgery reconstructions following bariatric surgery are challenging. 26 Plastic surgery reconstructions following bariatric surgery are challenging.…”

Comparative analysis on the effect of low‐thermal plasma dissection device (PEAK PlasmaBlade) versus conventional electro surgery in post‐bariatric body‐contouring procedures: A retrospective randomised clinical study

“…The need for post‐bariatric body‐contouring surgery is increasing in connection with the growth of bariatric surgery after massive weight loss. The reported morbidity is relatively high, approximately 50%, mostly related to various wound‐healing complications, such as seromas or haematomas, which can be managed conservatively and rarely require revisions . Wound‐healing problems may be caused, among other reasons, by conventional monopolar electrosurgical dissection technique and its associated thermal tissue damage and tissue ischaemia …”