A Comparative Analysis of Cytokeratin 18 and 19 Expressions in Odontogenic Keratocyst, Dentigerous Cyst and Radicular Cyst with a Review of Literature

Bhakhar, Vikas; Shah, Vandana; Ghanchi, Mohsin; Gosavi, Sandesh Sachchidanand; Srivastava, Himanshu Mahesh; Pachore, Nivedita Javahir

doi:10.7860/jcdr/2016/20535.8206

Cited by 5 publications

(7 citation statements)

References 25 publications

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“…The utility of CK-19 to identify odontogenic epithelium by numerous studies have been proved to be a useful tool in the diagnosis of cysts of odontogenic origin. [ 21 ] This study also supports this concept as there was 80% CK-19 positive expression in OKCs. Moreover, on analyzing each layer, surface and spinous cell layers stained positive with CK 19 [ Table 3 ], which is in accordance to studies conducted by Hayakawa et al ., Okada et al ., Pawar et al .…”

Section: Discussionsupporting

confidence: 78%

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Comparison of cytokeratin expressions among orthokeratinized odontogenic cysts, epidermoid cysts and odontogenic keratocysts: An immunohistochemical study

Padmapriya

Kavitha

Sivapathasundram

et al. 2020

J Oral Maxillofac Pathol

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Section: Discussionsupporting

confidence: 78%

“…CK-19 is expressed in odontogenic epithelium, secretory epithelium and in basal cells of squamous epithelium. [ 20 21 ]…”

Section: Discussionmentioning

confidence: 99%

Comparison of cytokeratin expressions among orthokeratinized odontogenic cysts, epidermoid cysts and odontogenic keratocysts: An immunohistochemical study

Padmapriya

Kavitha

Sivapathasundram

et al. 2020

J Oral Maxillofac Pathol

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“…Keratins are present in dental organs and therefore, in odontogenic cysts and tumors. The type and pattern of keratin expression were used to identify a cell and its different stages of differentiation ( 13 ). Providing the cytoskeleton and mechanical integrity of the epithelium is the main function of keratins.…”

Section: Introductionmentioning

confidence: 99%

“…Generally, keratins have been used as fundamental markers for differentiation of epithelial cells. Thus, studies were conducted to evaluate the role of keratins in pathogenesis, diagnosis, and treatment protocols for various epithelial lesions ( 13 ). Different keratin expressions in RC were studied before ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

The correlated expression of COX-2 and keratin 15 in radicular cysts

et al. 2022

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Background The expression of cyclooxygenase-2 (COX-2) and Keratin-15 (K15) in radicular cysts (RCs) is poorly understood. Identifying the expression of these two markers may modify the current treatment of RC. The objective of this study was to evaluate the expression of COX-2 and its relationship to K15 expression in the odontogenic epithelial cells of the RC. Material and Methods A total of 18 RCs were immunohistochemically analyzed for COX-2 and K15 expression. The cellular inflammatory reaction in the cyst wall was also assessed by measuring the percentage of inflammatory cells to the total number of cells. Results COX-2 expression in the odontogenic epithelium of RC was absent in 11.1 % (n=2), mild in 27.8 % (n=5), moderate in 22.2% (n=4) and strong in 38.9% (n=7). Meanwhile, K15 expression was absent in 27.8% (n=5), mild in 16.7% (n=3), moderate in 44.4% (n=8), and strong in 11.1% (n=2) of the cases. The inflammatory infiltrate was mild in 2 cases (11.1%), moderate in 6 cases (33.3%), and high in 10 cases (55.6%). Spearman’s correlation test revealed significant correlation (rho= .533; p = .023) between COX-2 and K15 expression in the odontogenic epithelium of RC. However, no correlation was noted between inflammation and expression of COX-2 (rho= 0.248, p =.321) or K15 (rho= -0.162, p = .520). Conclusions There is high and correlated expression of COX-2 and K15 in the odontogenic epithelium of RC. COX-2 could therefore be involved in epithelial cell differentiation of the cyst. Additionally, the expression of K15 in RC may be an indicator of epithelial cell differentiation. Key words: Cyclooxygenase, COX-2, Keratin-15, K15, Radicular cyst.

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“…Odontogenic cysts (OCs) are the commonest forms of cystic lesions that involve the maxillofacial area (Bhakhar et al, 2016). These are fluid filled pathological spaces, which are lined by odontogenic epithelium.…”

Section: Introductionmentioning

confidence: 99%

Stromal Expression of CD10 by Immunohistochemistry in Odontogenic Keratocyst (OKC), Dentigerous and Radicular Cysts and Its Correlation with Local Recurrence and Aggressive Behaviour

Ali

Asif

Ahmad

et al. 2019

Asian Pac J Cancer Prev

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Objective:To assess and compare the stromal expression of CD10 in OKC, dentigerous and radicular cysts. Materials and Methods: This comparative, cross sectional study was conducted at Armed Forces Institute of Pathology (AFIP), Rawalpindi, from Jan 2017 to Dec 2017. Total sixty cases comprising 20 of each OKC, Dentigerous and Radicular cysts were included in this study. Hematoxylin and eosin (H and E) sections were performed followed by immunohistochemical staining for CD10 antibody. Expression of CD10 was evaluated and compared. Results were analyzed by using SPSS version 20.0. Chi Square test was performed with P value < 0.05 was considered as significant. Results: A total of 60 cases, 20 of each OKC, dentigerous and radicular cysts were taken. In our study, 38 (63.3%) male and 22 (36.7%) female patients with the mean age of 32 ± 15 (mean ± SD) were included. Percentage of CD10 positive cells were highest in sub-epithelial stroma of OKC (95% cases) as compared to radicular and dentigerous cysts (60 and 70%) with highest number of cases showing intense staining in OKC 13(65%) as compared to other odontogenic cysts i-e 4(20%) and 2 (10%) respectively. There was a statistically significant association between odontogenic cysts and proportional score, intensity score and combined score of stromal CD10 expression (P=0.009, p=0.001 and p=0.000). Conclusion: In this study, we found that highest stromal CD10 expression in OKC as compared to dentigerous and radicular cyst, which might be due to aggressive behaviour and increased risk of recurrence in OKC. Expression of CD10 marker will further aid the clinician to plan appropriate surgical intervention and keep regular follow-ups to identify recurrences.

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A Comparative Analysis of Cytokeratin 18 and 19 Expressions in Odontogenic Keratocyst, Dentigerous Cyst and Radicular Cyst with a Review of Literature

Cited by 5 publications

References 25 publications

Comparison of cytokeratin expressions among orthokeratinized odontogenic cysts, epidermoid cysts and odontogenic keratocysts: An immunohistochemical study

Comparison of cytokeratin expressions among orthokeratinized odontogenic cysts, epidermoid cysts and odontogenic keratocysts: An immunohistochemical study

The correlated expression of COX-2 and keratin 15 in radicular cysts

Stromal Expression of CD10 by Immunohistochemistry in Odontogenic Keratocyst (OKC), Dentigerous and Radicular Cysts and Its Correlation with Local Recurrence and Aggressive Behaviour

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