A Comparative Analysis of Genistein and Daidzein in Affecting Lipid Metabolism in Rat Liver

Takahashi, Yōko; Odbayar, Tseye-Oidov; Ishii, Takashi

doi:10.3164/jcbn.08-211

Cited by 43 publications

(31 citation statements)

References 24 publications

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“…This is supported by the evidence that the effects of GEN and DZN parallel those produced by the antioxidant SOD [see 6]. Thus, although other effects of GEN as a dietary compound inducing hormonal, metabolic and expression changes [55,56] cannot be ruled out, we maintain that its role as an antioxidant is crucial in accounting for these experimental findings. Accordingly, we first showed that these compounds can remove the extra ROS produced in cells undergoing apoptosis (Fig.…”

Section: Discussionsupporting

confidence: 67%

Genistein and daidzein prevent low potassium-dependent apoptosis of cerebellar granule cells

Atlante

Bobba

Paventi

et al. 2010

Biochemical Pharmacology

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 of 39A c c e p t e d M a n u s c r i p t 1 A c c e p t e d M a n u s c r i p t 2 GENISTEIN AND DAIDZEIN PREVENT LOW POTASSIUM-DEPENDENT APOPTOSIS OF CEREBELLAR GRANULE CELLS AbstractWe have investigated the ability of certain dietary flavonoids, known to exert beneficial effects on the central nervous system, to affect neuronal apoptosis. We used cerebellar granule cells undergoing apoptosis due to potassium deprivation in a serum-free medium in either the absence or presence of the flavonoids genistein and daidzein, which are present in soy, and of catechin and epicatechin, which are present in cocoa. These compounds were used in a blood dietary concentration range. We found that genistein and daidzein, but not catechin and epicatechin, prevented apoptosis, with cell survival measured 24 h after the induction of apoptosis being higher than that of the same cells incubated in flavonoid free medium (80 and 40%, respectively); there was no effect in control cells. A detailed investigation of the effect of these compounds on certain mitochondrial events that occur in cells en route to apoptosis showed that genistein and daidzein prevented the impairment of glucose oxidation and mitochondrial coupling, reduced cytochrome c release, and prevented both impairment of the adenine nucleotide translocator and opening of the mitochondrial permeability transition pore. Interestingly, genistein and daidzein were found to reduce the levels of reactive oxygen species, which are elevated in cerebellar granule cell apoptosis.These findings strongly suggest that the prevention of apoptosis depends mainly on the antioxidant properties of genistein and daidzein. This could lead to the development of a flavonoid-based therapy in neuropathies.

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Section: Discussionsupporting

confidence: 67%

Genistein and daidzein prevent low potassium-dependent apoptosis of cerebellar granule cells

Atlante

Bobba

Paventi

et al. 2010

Biochemical Pharmacology

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“…Pancreatic cells showed the involvement of EGFR and the putative NFjB target EGR1 in the response to the phytoestrogen [193]. Similar effects have been shown in several others cellular systems [194][195][196] and in mice [197][198][199]. Genistein effects clearly depend on the dosage with pro-estrogenic activities being dominant at lower and anti-apoptotic activities at higher concentrations [200], similar observations have been reported by Konstantakopoulos et al [201].…”

Section: Anti-angiogenic Phytoestrogenssupporting

confidence: 73%

Functional genomics of endothelial cells treated with anti-angiogenic or angiopreventive drugs

Albini

Indraccolo

Noonan

et al. 2010

Clin Exp Metastasis

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Angiogenesis is a highly regulated physiological process that has been studied in considerable detail given its importance in several chronic pathologies. Many endogenous factors and hormones intervene in the regulation of angiogensis and classical as well as targeted drugs have been developed for its control. Angiogenesis inhibition has come off the bench and entered into clinical application for cancer therapy, particularly for metastatic disease. While the clinical benefit is currently in terms of months, preclinical data suggest that novel drugs and drug combinations could lead to substantial improvement. The many targets of endogenous angiogenesis inhibitors reflect the complexity of the process; in contrast, current clinical therapies mainly target the vascular endothelial growth factor system. Cancer chemopreventive compounds can retard tumor insurgence and delay or prevent metastasis and many of these molecules hinder angiogenesis, a mechanism that we termed angioprevention. Angiopreventive drugs appear to prevalently act through the inhibition of the pro-inflammatory and anti-apoptotic player NFkappaB, thus contrasting inflammation dependent angiogenesis. Relatively little is known concerning the effects of these angiogenesis inhibitors on gene expression of endothelial cells, the main target of many of these molecules. Here we provide an exhaustive list of anti-angiogenic molecules, and summarize their effects, where known, on the transcriptome and functional genomics of endothelial cells. The regulation of specific genes can be crucial to preventive or therapeutic intervention. Further, novel targets might help to circumvent resistance to anti-angiogenic therapy. The studies we review are relevant not only to cancer but also to other chronic degenerative diseases involving endothelial cells, such as cardiovascular disorders, diabetes, rheumatoid arthritis and retinopaties, as well as vessel aging.

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“…Genistein and daizein modulate the hepatic glucose and lipid-regulating enzyme activities. 4,5) Two meta-analyses have reported that the intake of soy protein and isoflavone reduced the levels of serum total cholesterol, LDL-cholesterol and triglycerides, and increased that of HDL-cholesterol. 6,7) The recently increasing use of soy food in diets has thus aroused a surge of interest in the potential physiological benefits.…”

mentioning

confidence: 99%

Effects of Lactic Acid-Fermented Soymilk on Lipid Metabolism-Related Gene Expression in Rat Liver

Kobayashi¹,

Harada²,

Takagi³

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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A Comparative Analysis of Genistein and Daidzein in Affecting Lipid Metabolism in Rat Liver

Cited by 43 publications

References 24 publications

Genistein and daidzein prevent low potassium-dependent apoptosis of cerebellar granule cells

Genistein and daidzein prevent low potassium-dependent apoptosis of cerebellar granule cells

Functional genomics of endothelial cells treated with anti-angiogenic or angiopreventive drugs

Effects of Lactic Acid-Fermented Soymilk on Lipid Metabolism-Related Gene Expression in Rat Liver

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