“…Furthermore, on evaluating the impact of the severity of the disease on the total cost of care, it was observed that the cost of controlled patients (health state 1) was three times lower than that of patients found in health state 5, which is consistent with published studies in which the cost of care for patients in advanced health states is 2 to 16 times the cost of care of the controlled patients [18,20,[44][45][46].…”