A Comparative Analysis of the Relative Efficacy of Vector-Control Strategies Against Dengue Fever

Amaku, Marcos; Coutinho, Francisco Antônio Bezerra; Raimundo, Silvia Martorano; López, Luis Fernández; Burattini, Marcelo Nascimento; Massad, Eduardo

doi:10.1007/s11538-014-9939-5

Cited by 47 publications

(57 citation statements)

References 41 publications

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“…Another knowledge gap identified here is the scarcity of data on cost effectiveness of vector control strategies in systematic reviews [27]. Bearing in mind that Health Economics is currently a major element in decision making processes, future studies should address this gap [37, 38]. This is particularly important considering the significant burden of dengue and other vector-borne diseases (including Zika and yellow fever) and the international commitment to improve global health and eradicate poverty related diseases with finite financial means.…”

Section: Discussionmentioning

confidence: 99%

Public Health Interventions for Aedes Control in the Time of Zikavirus– A Meta-Review on Effectiveness of Vector Control Strategies

et al. 2016

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BackgroundThere is renewed interest in effective measures to control Zika and dengue vectors. A synthesis of published literature with a focus on the quality of evidence is warranted to determine the effectiveness of vector control strategies.MethodologyWe conducted a meta-review assessing the effectiveness of any Aedes control measure. We searched Scopus and Medline for relevant reviews through to May 2016. Titles, abstracts and full texts were assessed independently for inclusion by two authors. Data extraction was performed in duplicate and validity of the evidence was assessed using GRADE criteria.Findings13 systematic reviews that investigated the effect of control measures on entomological parameters or disease incidence were included. Biological controls seem to achieve better reduction of entomological indices than chemical controls, while educational campaigns can reduce breeding habitats. Integrated vector control strategies may not always increase effectiveness. The efficacy of any control programme is dependent on local settings, intervention type, resources and study duration, which may partly explain the varying degree of success between studies. Nevertheless, the quality of evidence was mostly low to very low due to poor reporting of study design, observational methodologies, heterogeneity, and indirect outcomes, thus hindering an evidence-based recommendation.ConclusionsThe evidence for the effectiveness of Aedes control measures is mixed. Chemical control, which is commonly used, does not appear to be associated with sustainable reductions of mosquito populations over time. Indeed, by contributing to a false sense of security, chemical control may reduce the effectiveness of educational interventions aimed at encouraging local people to remove mosquito breeding sites. Better quality studies of the impact of vector control interventions on the incidence of human infections with Dengue or Zika are still needed.

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Section: Discussionmentioning

confidence: 99%

Public Health Interventions for Aedes Control in the Time of Zikavirus– A Meta-Review on Effectiveness of Vector Control Strategies

et al. 2016

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“…We decided not to include diagrams for the two models (measles and Zika) to save editorial space, since the structure of both the Kermack-Mackendrick model [26] of the first case and the Ross-Macdonald model [18] for the second case are well known.…”

Section: The Case Of Zika Virus In Brazilmentioning

confidence: 99%

“…In this Appendix we describe the Ross-Macdonald [18] model used for the sensitivity analysis of Case 2.…”

Section: Bmentioning

confidence: 99%

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A Note on the Risk of Infections Invading Unaffected Regions

Amaku

Coutinho

Armstrong

et al. 2018

Computational and Mathematical Methods in Medicine

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We present two probabilistic models to estimate the risk of introducing infectious diseases into previously unaffected countries/regions by infective travellers. We analyse two distinct situations, one dealing with a directly transmitted infection (measles in Italy in 2017) and one dealing with a vector-borne infection (Zika virus in Rio de Janeiro, which may happen in the future). To calculate the risk in the first scenario, we used a simple, nonhomogeneous birth process. The second model proposed in this paper provides a way to calculate the probability that local mosquitoes become infected by the arrival of a single infective traveller during his/her infectiousness period. The result of the risk of measles invasion of Italy was of 93% and the result of the risk of Zika virus invasion of Rio de Janeiro was of 22%.

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“…We carried out detailed equilibrium analysis in a related article [18]. For our purposes, we calculate the equilibrium densities of I M *, the number of infected mosquitoes:

\begin{matrix} I_{M}^{*} = (δ_{H} + μ_{H}) (μ_{H} + γ_{H} + α_{H} + σ_{H}) I_{H}^{*} \\ \times (a b δ_{H} \\ \times (1 - (\frac{(μ_{H} + σ_{H}) (μ_{H} + γ_{H} + α_{H} + δ_{H} + θ_{H}) + γ_{H} δ_{H}}{δ_{H} (μ_{H} + σ_{H})}) \\ {\times \frac{I_{H}^{*}}{N_{H}^{*}}))}^{- 1} . \end{matrix}

…”

Section: The Modelmentioning

confidence: 99%

Maximum Equilibrium Prevalence of Mosquito-Borne Microparasite Infections in Humans

Amaku

Burattini

Coutinho

et al. 2013

Computational and Mathematical Methods in Medicine

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To determine the maximum equilibrium prevalence of mosquito-borne microparasitic infections, this paper proposes a general model for vector-borne infections which is flexible enough to comprise the dynamics of a great number of the known diseases transmitted by arthropods. From equilibrium analysis, we determined the number of infected vectors as an explicit function of the model's parameters and the prevalence of infection in the hosts. From the analysis, it is also possible to derive the basic reproduction number and the equilibrium force of infection as a function of those parameters and variables. From the force of infection, we were able to conclude that, depending on the disease's structure and the model's parameters, there is a maximum value of equilibrium prevalence for each of the mosquito-borne microparasitic infections. The analysis is exemplified by the cases of malaria and dengue fever. With the values of the parameters chosen to illustrate those calculations, the maximum equilibrium prevalence found was 31% and 0.02% for malaria and dengue, respectively. The equilibrium analysis demonstrated that there is a maximum prevalence for the mosquito-borne microparasitic infections.

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A Comparative Analysis of the Relative Efficacy of Vector-Control Strategies Against Dengue Fever

Abstract: 20Background. Dengue is considered one of the most important vector-borne infection, 21

Cited by 47 publications

References 41 publications

Public Health Interventions for Aedes Control in the Time of Zikavirus– A Meta-Review on Effectiveness of Vector Control Strategies

Public Health Interventions for Aedes Control in the Time of Zikavirus– A Meta-Review on Effectiveness of Vector Control Strategies

A Note on the Risk of Infections Invading Unaffected Regions

Maximum Equilibrium Prevalence of Mosquito-Borne Microparasite Infections in Humans

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