A comparative analysis of virucidal efficiency of biocide agents

Nosik, Nikolay N; Носик, Д Н; Чижов, А Я

doi:10.18821/0507-4088-2017-62-1-41-45

Cited by 7 publications

(3 citation statements)

References 1 publication

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“…– the insufficient potential of single agents for effective inactivation of viruses [ 21 ] and bacteria and fungi resistant to CDs.…”

Section: Resultsmentioning

confidence: 99%

Strategy for the Choice of Disinfectants in Practical Medicine and Production

Bogdanova,

Chemykh

2023

Pharm Chem J

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The problem of the strategy for choosing disinfectants in practical medicine is considered. The pandemic of the new coronavirus infection posed new problems for disinfectology. The expanded spectrum of disinfectants and antiseptics offered by the chemical industry in recent years requires justification for the choice in favor of any product. The goals and types of disinfection considered from current positions and the main groups of disinfectants used in Russia and their properties and spectra of activity are presented.

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“…– the insufficient potential of single agents for effective inactivation of viruses [ 21 ] and bacteria and fungi resistant to CDs.…”

Section: Resultsmentioning

confidence: 99%

Strategy for the Choice of Disinfectants in Practical Medicine and Production

Bogdanova,

Chemykh

2023

Pharm Chem J

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“…In the suspension tests, QACx500 could not inactivate RVA in 1 min. It is indeed reasonable that a non-enveloped virus will not be inactivated with QAC [ 32 , 33 ]. FdCa(OH) 2 was shown to be able to inactivate BCoV, an enveloped virus, in 5 s, as well as an avian coronavirus, i.e., infectious bronchitis virus (IBV) [ 4 ], in contrast to avian influenza virus (AIV) or Newcastle disease virus (NDV), which required more than 10 min [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Virucidal Quantitative Carrier Test towards Bovine Viruses for Surface Disinfectants While Simulating Practical Usage on Livestock Farms

et al. 2022

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Livestock farming is affected by the occurrence of infectious diseases, but outbreaks can be prevented by effective cleaning and disinfection along with proper farm management. In the present study, bovine coronavirus (BCoV) and bovine rotavirus A (RVA) were inactivated using food additive-grade calcium hydroxide (FdCa(OH)2) solution, quaternary ammonium compound (QAC) and their mixture through suspension tests as the primary screening, and afterward via carrier tests using dropping or dipping techniques as the secondary screenings. Viruses in the aqueous phase can be easily inactivated in the suspension tests, but once attached to the materials, they can become resistant to disinfectants, and require longer times to be inactivated. This highlights the importance of thorough cleaning with detergent before disinfection, and keeping elevated contact durations of proper disinfectants to reduce viral contamination and decrease infectious diseases incidence in farms. It was also reaffirmed that the suspension and carrier tests are necessary to evaluate disinfectants and thus determine their actual use. Particularly, the mixture of QAC and FdCa(OH)2 was found to exhibit synergistic and broad-spectrum effects compared to their use alone, and is now recommended for use on livestock farms.

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“…В работе использовали 150 экспериментально-производственных образцов нормальных иммуноглобулинов человека, полученных от доноров плазмы, не вакцинированных герпетической вакциной («Микроген» Минздрава РФ («Иммунопрепарат», Уфа); станция переливания крови ФМБА, Москва). Экспериментально-производственные образцы иммуноглобулина получены методом многостадийного низкотемпературного этанольного фракционирования белков плазмы по Кону и проверены в соответствии с международными требованиями и нормативными документами по исследованию плазмы крови человека и препаратов иммуноглобулинов [10,[11][12][13][14][15][16][17].…”

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Development of the suppository form of human immunoglobulin preparation with high titers of antibodies to herpes simplex virus types 1 and 2 for the treatment of chronic forms of herpetic disease

Лазаренко¹,

Lm²,

Mordvintseva³

et al. 2017

Problems of Virology

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In spite of the vast arsenal of therapeutic agents, therapy of herpes virus infection (HVI) is very difficult, particularly in pregnant women, newborns and children in the first years of life, as well as in patients with immune deficiency. In this regard, possibility of using immunoglobulins for the treatment of HVI is currently attracting the attention of doctors. The aim of this work was to develop a suppository form of the drug containing donor immunoglobulins with high levels of neutralizing antibodies to herpes simplex virus types 1 and 2 for the treatment of chronic forms of herpetic disease. The study included the following steps: 1) selection of gamma-globulins with high antibody titer for HSV-1 and HSV-2 ELISA test; 2) determination of the level of neutralizing antibodies in the selected series of gamma-globulins in tests in tissue cultures and animals; 3) lyophilization of immunoglobulins; 4) development of the suppository form of the preparation containing gamma-globulin donors with high levels of neutralizing antibodies to HSV-1 and HSV-2; 5) study of the safety of the activity of neutralizing antibodies to HSV-1 and HSV-2 in the suppository form of the drug with hyaluronic acid used as immunomodulator. As the result of this work, immunoglobulin preparation in the suppository form was developed. The developed preparation meets the requirements for safety and efficacy. It is not toxic or pyrogenic. The problems of clinical use of this drug as a method of HVI therapy are discussed.

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A comparative analysis of virucidal efficiency of biocide agents

Cited by 7 publications

References 1 publication

Strategy for the Choice of Disinfectants in Practical Medicine and Production

Strategy for the Choice of Disinfectants in Practical Medicine and Production

Evaluation of Virucidal Quantitative Carrier Test towards Bovine Viruses for Surface Disinfectants While Simulating Practical Usage on Livestock Farms

Development of the suppository form of human immunoglobulin preparation with high titers of antibodies to herpes simplex virus types 1 and 2 for the treatment of chronic forms of herpetic disease

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