The main groups of biocide agents used for inactivation of bacteria and viruses were studied for their virucidal activity against enveloped (HIV, viral hepatitis C, influenza virus A) and non-enveloped viruses (poliovirus, adenovirus). Their efficiency was analyzed. Quarterly ammonium compounds (QAC) themselves are not able to properly inactivate non-enveloped viruses. However, they can be successfully applied in combination with other biocides (guanidines, aldehydes). Effective composition of QAC with amines and guanidines provided inactivation of viruses (4.0 lgTCID50) in concentrations of 0.166-0.280% for non-enveloped viruses and 0.080-00.185% for enveloped viruses. The combination of QAC with aldehydes is especially effective (0.04-0.64% for non-enveloped viruses). The virucidal efficiency does not directly depend on the QAC concentration in the chemical disinfectants.

The identification of causation and incidence between the impact of environmental factors and changes in the human adaptive potential is one of the urgent tasks of ecological and biological monitoring. The aim: a comparative assessment of the state activity of functional systems, imbalance and the nature of adaptation reactions of the body in foreign students, students from Russia and the Commonwealth of Independent States (CIS). Methods. The activity of the functional systems and the imbalance were determined by the method of electropuncture diagnostics (EPD) according to Y. Nakatani. 180 men­students (aged 18­22) of PFUR from Russia, CIS, Southeast Asia, Middle East, Latin America and Africa were examined (30 people in each group). The nature of the adaptive reactions of the body was evaluated in 916 students by the method of L.H. Garkavi et al. To determine the adaptation reactions, 200 peripheral blood cells were analyzed. Results. It was found that the lower the average current and the higher the degree of imbalance in EPD in foreign students from different climatic and geographical zones, the more the percentage of unfavorable adaptation reactions is noted ­ correlation coefficients r = ­0.9048 and r = +0.8989, respectively. Unfavorable adaptation reactions ­ acute stress, chronic stress and reaction of re­activation (AS, ChS, REA), to a greater degree reaction of extra activation, were more often observed in students from Africa and Latin America. Conclusions. The change in climatic, ecological, chronobiological and social conditions in foreign students is accompanied by a significant decrease in the energy potential, expressed by an imbalance in the activity of the body’s functional systems and, accordingly, to a greater extent, by manifestations of adverse adaptive reactions­stress and reaction of re­activation. Revealing the dependence in change of climatic­ecological and social living conditions with a reliable deterioration in the indicators of the functional state of young people most clearly indicates the need for a purposeful correction of the adaptation potential in foreign students coming to study in the Moscow megapolis.

The aim of the study was to perform a comparative analysis of hair content of toxic metal in foreign students originating from different regions.Material and methods. An examination of first-year students of the RUDN University originating from Russia, Asia, the Middle East, Africa, and Latin America was performed in the study. Assessment of hair aluminum (Al), arsenic (As), cadmium (Cd), mercury (Hg), lead (Pb) and tin (Sn) content was undertaken using inductively-coupled plasma mass spectrometry.Results. The obtained data demonstrate that the highest levels of Al, Cd, and Pb were observed in students originating from Africa and Latin America. The most prominent mercury accumulation was detected in subjects from Latin America. In turn, hair As content in foreign students from all regions exceeded the respective Russian values by a factor of more than two. No significant group difference in hair tin content was observed. In regression models, prior habitation in Asia, Africa, and Latin America is considered as a significant predictor of elevated hair Hg content. African origin was also associated with higher Pb levels in hair. In the case of cadmium, a direct relationship between prior habitation in Latin America tended to be significant.Conclusion. The obtained data revealed increased accumulation of toxic metals, especially, Hg, Pb, and Cd in the hair of foreign first-year students originating from Africa and Latin America, that may have a significant adverse effect on health and educational performance. At the same time, further studies aimed at investigating the particular contribution of toxic metal overload to health effects in RUDN University students are required.