A Comparative Assessment of Serum Creatinine and Cystatin C as a Significance of Nephropathy in Diabetic Patients

AL-Nasrawii, Maytham Salim; Jasim, Balqees Sadoon; Hassan, Salim Hussein

doi:10.37268/mjphm/vol.20/no.3/art.527

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…The most prominent pharmacological benefit was observed at the dose of 20 mg/kg. Dyslipidaemia is a well‐recognized risk factor for the DN and is caused by impaired action of lipoprotein lipase (LPL) that is localized to the endothelial cells (Jasim et al, 2020; Sanyal et al, 2020). It results in increased serum levels of increased triglyceride (TG), total cholesterol (TC) and decreased high‐density lipoprotein (HDL) (Kuwabara et al, 2012; Opazo‐Ríos et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

Local anaesthetic procaine derivatives protect rat against diabetic nephropathy via inhibition of DPP‐4, inflammation and oxidative stress

Song

Chen

2023

Chem Biol Drug Des

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Diabetic nephropathy (DN) is a serious devastating disease. However, the current clinical options to treat DN are not adequate. Thus, in the present study, we intend to develop novel series of procaine‐embedded thiazole‐pyrazoles as protective agent against DN. The compounds were tested for inhibition of dipeptidyl peptidase (DPP)‐4, −8, and − 9 enzyme subtypes, where they selectively and potently inhibit DPP‐4 as compared to other subtypes. The top three ranked DPP‐4 inhibitors (8i, 8e and 8k) were further screened for inhibitory activity against NF‐ĸB transcription. Among these three, compound 8i was identified as the most potent NF‐ĸB inhibitor. The pharmacological benefit of compound 8i was further established in streptozotocin‐induced diabetic nephropathy in rats. Compound 8i showed marked improvements in blood glucose, ALP, ALT, total protein, serum lipid profile such as total cholesterol, triglyceride, HDL levels and renal functions such as urine volume, urinary protein excretion, serum creatinine, blood urea nitrogen and creatinine clearance as compared to nontreated diabetic control group. It also reduces oxidative stress (MDA, SOD and GPx) and inflammation (TNF‐α, IL‐1β and IL‐6) in the rats as compared to disease control group rats. This study demonstrated the discovery of procaine‐embedded thiazole‐pyrazole compounds as a novel class of agent against diabetic nephropathy.

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Section: Resultsmentioning

confidence: 99%

Local anaesthetic procaine derivatives protect rat against diabetic nephropathy via inhibition of DPP‐4, inflammation and oxidative stress

Song

Chen

2023

Chem Biol Drug Des

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Discovery of novel ketamine‐inspired derivatives as a protective agent against renal ischemic/reperfusion injury in Wistar rats

Zhu

Yin

2022

Chem Biol Drug Des

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Renal ischemia‐reperfusion (I/R) injury is a limiting factor for the success of renal grafts and is deemed greatly responsible for the mortality. A novel series of ketamine‐inspired compounds was synthesized and subjected to NF‐ĸB transcriptional inhibitory activity in LPS‐stimulated RAW264.7 cells, where entire set of compounds showed mild‐to‐moderate significant NF‐ĸB transcriptional inhibitory activity (IC50 6.53–67.52 µM). Compound 6d showed highest inhibitory activity among the tested series (IC50 2.62 µM) and found more potent as compared to ketamine as standard. The effect of compound 6d was further quantified in I/R injury in Wistar rats, where it dose‐dependently improves kidney function of rats with significant amelioration of kidney injury as suggested by histopathologic examination of renal tissues. It further showed reduction in the generation of pro‐inflammatory cytokines and improves the antioxidant status of experimental rats. Compound 6d inhibited apoptosis and increases the expression of Bcl2 and decreases Bax, and cleaved caspase‐3 level. It further reduces TLR‐4 and NF‐κB expression in renal cells of rats, with increases in IκB‐α level in Western blot analysis as compared to I/R group. In summary, our current study showed the development of a novel class of ketamine‐inspired derivatives against renal ischemia/reperfusion injury.

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Assessing the accuracy of cystatin C for estimating glomerular filtration rate in patients with kidney disease

Ismael,

Raoof,

Tahseen

2024

APJMBB

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The diagnosis, staging, and prognosis of chronic kidney disease (CKD) depend on the measurement of the glomerular filtration rate (GFR). A low GFR is associated with an increased risk of cardiovascular disease and early mortality. Current guidelines for CKD recommend using cystatin C as a supplementary test to ensure accurate estimation of eGFR. In the present study, we aimed to compare the efficacy of cystatin C-based eGFR with serum creatinine-based eGFR before and after contrast-enhanced intravenous urography (IVU). The present study is a retrospective observational study conducted in 51 patients aged 10 to 70 years. Of these patients, 21 were female and 30 were male, all of whom had kidney diseases and attended the hospital from January 2021 to January 2022. In this study, we evaluated the serum levels of urea, creatinine, and cystatin C before and after administering iodine solution to each participant. The study found no significant changes in blood urea and serum creatinine levels before and after administering the iodine solution. However, there was a significant variation in the levels of cystatin C. The levels of eGFR-dependent creatinine did not differ significantly, but there were significant changes in eGFR-dependent cystatin levels. Our findings suggest that cystatin C is a more accurate method of monitoring kidney function compared to creatinine levels. Additionally, cystatin C appears to be a more reliable marker of renal failure than serum creatinine and urea.

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A Comparative Assessment of Serum Creatinine and Cystatin C as a Significance of Nephropathy in Diabetic Patients

Cited by 3 publications

References 14 publications

Local anaesthetic procaine derivatives protect rat against diabetic nephropathy via inhibition of DPP‐4, inflammation and oxidative stress

Local anaesthetic procaine derivatives protect rat against diabetic nephropathy via inhibition of DPP‐4, inflammation and oxidative stress

Discovery of novel ketamine‐inspired derivatives as a protective agent against renal ischemic/reperfusion injury in Wistar rats

Assessing the accuracy of cystatin C for estimating glomerular filtration rate in patients with kidney disease

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