A Comparative Clinical Evaluation of Oral Clonidine vs. Pregabalin Premedication for Attenuation of Haemodynamic Response to Laryngoscopy and Intubation- A Prospective Randomised Double Blinded Placebocontrolled Study

Soni, Megha; Grover, Niharika; Sood, Suvidha

doi:10.18410/jebmh/2019/143

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…They observed that clonidine (200 µg) is better in decreasing the HR as compared to pregabalin (150mg) which was statistically significant after induction and 10 min post laryngoscopy and intubation. 18 Both clonidine (200 µg) and pregabalin (150mg) provided adequate anxiolysis and sedation in preoperative period which is in accordance with studies conducted by Gupta et al, Chandra et al and Waikar et al 13,15,19…”

Section: Discussionsupporting

confidence: 84%

A comparative study of efficacy of oral pregabalin and clonidine for attenuation of pressor response to intubation

Kaur

Gupta

Singh

et al. 2021

Int J Basic Clin Pharmacol

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Background: Endotracheal intubation is associated with hemodynamic stress responses. Various drugs have been used in the past to attenuate the pressor response; however, none has been proved to be ideal. Present study was planned to evaluate the oral pregabalin 150 mg and clonidine 200 µg for attenuation of pressor response to intubation.Methods: The study was conducted on 100 adult patients of either gender scheduled to undergo elective surgeries under general anaesthesia (GA). The patients were randomly allocated into 2 groups. In group A patients received pregabalin 150mg and in group B patients received clonidine 200µg orally. The hemodynamic parameters were recorded until 10 minutes after intubation. The sedation, anxiety and side effects were also assessed.Results: In clonidine group, the mean HR remained below the baseline value at all the time intervals. In pregabalin group, the mean HR remained below the baseline value at most of the time intervals but increased above baseline just after intubation (T0i) and 1 minute after intubation (T1i) where increase was only 1.488±1.20% and 0.45±1.16% respectively from baseline. In both pregabalin and clonidine groups, the mean SBP and MAP remained below the baseline value (Tb) at all the time intervals from T0.5 to T10i. Both clonidine and pregabalin provided adequate anxiolysis and sedation with pregabalin providing more pronounced sedation and anxiolysis than clonidine.Conclusions: Both clonidine and pregabalin are effective oral premedication drugs for attenuation of the pressor response to laryngoscopy and endotracheal intubation.

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Section: Discussionsupporting

confidence: 84%

A comparative study of efficacy of oral pregabalin and clonidine for attenuation of pressor response to intubation

Kaur

Gupta

Singh

et al. 2021

Int J Basic Clin Pharmacol

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“…In other studies, Gupta et al, 14 Raichurkar et al, 15 Soni et al, 16 and Murari et al, 17 concluded that oral clonidine in a dose of 0.2 mg was effective in blunting sympathoadrenal responses HR to laryngoscopy and intubation.…”

Section: Discussionmentioning

confidence: 94%

A comparative evaluation of gabapentin and clonidine for attenuating pressor responses to laryngoscopy and endotracheal intubation in hypertensive patients-A prospective double-blinded clinical study

Richa Parihar,

Anju Gautam,

Nancy Ekka

et al. 2023

Asian J Med Sci

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Background: Endotracheal intubation forms an indispensable part of general anesthesia. Various adjuvants have been added to diminish the hemodynamic stress response associated with it. These changes are more marked in hypertensive individuals. Aims and Objectives: The aim of the present study was to compare the efficacy of oral clonidine and oral gabapentin and their associated side effects if any; for attenuation of hemodynamic responses following laryngoscopy and tracheal intubation in hypertensive patients. Materials and Methods: A total of 108 hypertensive patients with American Society of Anesthesiologists grade II/III scheduled for elective surgeries requiring general anesthesia were randomly allocated into three groups receiving Group G Tablet gabapentin 800 mg, Group C Tablet clonidine 0.2 mg, and Group P placebo (multivitamin tablets) given 2 h before surgery with a sip of water. The hemodynamic parameters such as heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and adverse events during the perioperative period were noted. The statistical analysis was done by paired t-test, ANOVA, and Chi-square test and by SPSS22 software. Results: The demographic data were comparable in all three groups. There was no significant difference at baseline for HR, SBP, DBP, and MBP in all three groups. The mean HR was significantly lower in Group C as compared to Group G and Group P (P<0.013). The mean SBP, DBP, and MBP was significantly lower in Groups C and G as compared to Group P (P<0.01) before induction, after induction after laryngoscopy and intubation, then at 5, 10, 15, 20, 25, and 30 min after intubation. Conclusion: Clonidine and gabapentin in the abovementioned doses can be safely used for attenuating hemodynamic stress response. Clonidine proved to have better hemodynamic stability and tends to be more effective in attenuating pressor response laryngoscopy and intubation in hypertensive patients when compared to gabapentin.

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A Comparative Clinical Evaluation of Oral Clonidine vs. Pregabalin Premedication for Attenuation of Haemodynamic Response to Laryngoscopy and Intubation- A Prospective Randomised Double Blinded Placebocontrolled Study

Cited by 2 publications

References 14 publications

A comparative study of efficacy of oral pregabalin and clonidine for attenuation of pressor response to intubation

A comparative study of efficacy of oral pregabalin and clonidine for attenuation of pressor response to intubation

A comparative evaluation of gabapentin and clonidine for attenuating pressor responses to laryngoscopy and endotracheal intubation in hypertensive patients-A prospective double-blinded clinical study

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