A Comparative Histological Study of Wound Healing following Nd:YAG Laser with Different Energy Parameters and Conventional Surgical Incision in Rat Skin

Romanos, George E.; Pelekanos, Stavros; Strub, J. R.

doi:10.1089/clm.1995.13.11

Cited by 20 publications

(8 citation statements)

References 14 publications

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“…A comparison of wound healing following irradiation by the Nd:YAG and CO 2 lasers indicates that CO 2 laser-induced wounds in oral, oropharyngeal, and laryngeal mucosa healed significantly faster than those created by the Nd:YAG laser, but both heal slower than the conventional scalpel-induced wound. 13 Delayed healing of Nd:YAG laser wounds compared to scalpel incisions also has been reported by Romanos et al 18 but only when using 3 W of power and a 20-Hz pulse rate. Healing was equivalent for scalpel and Nd: YAG wounds when the laser was used at a lower power setting of 1.75 W and 20 Hz.…”

Section: Characteristics Of Laser Wavelengths Used In Clinical Dentistrysupporting

confidence: 52%

Lasers in Periodontics: A Review of the Literature

Cobb

2006

Journal of Periodontology

307

225

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Background: Despite the large number of publications, there is still controversy among clinicians regarding the application of dental lasers to the treatment of chronic periodontitis. The purpose of this review is to analyze the peer-reviewed research literature to determine the state of the science concerning the application of lasers to common oral soft tissue problems, root surface detoxification, and the treatment of chronic periodontitis.Methods: A comprehensive computer-based search combined the following databases into one search: Medline, Current Contents, and the Cumulated Index of Nursing and Allied Health. This search also used key words. In addition, hand searches were done for several journals not cataloged in the databases, and the reference lists from published articles were checked. All articles were considered individually to eliminate non-peer-reviewed articles, those dealing with commercial laser technology, and those considered by the author to be purely opinion articles, leaving 278 possible articles.Results: There is a considerable conflict in results for both laboratory studies and clinical trials, even when using the same laser wavelength. A meaningful comparison between various clinical studies or between laser and conventional therapy is difficult at best and likely impossible at the present. Reasons for this dilemma are several, such as different laser wavelengths; wide variations in laser parameters; insufficient reporting of parameters that, in turn, does not allow calculation of energy density; differences in experimental design, lack of proper controls, and differences in severity of disease and treatment protocols; and measurement of different clinical endpoints.Conclusions: Based on this review of the literature, there is a great need to develop an evidence-based approach to the use of lasers for the treatment of chronic periodontitis. Simply put, there is insufficient evidence to suggest that any specific wavelength of laser is superior to the traditional modalities of therapy. Current evidence does suggest that use of the Nd:YAG or Er:YAG wavelengths for treatment of chronic periodontitis may be equivalent to scaling and root planing (SRP) with respect to reduction in probing depth and subgingival bacterial populations. However, if gain in clinical attachment level is considered the gold standard for non-surgical periodontal therapy, then the evidence supporting laser-mediated periodontal treatment over traditional therapy is minimal at best. Lastly, there is limited evidence suggesting that lasers used in an adjunctive capacity to SRP may provide some additional benefit.

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Section: Characteristics Of Laser Wavelengths Used In Clinical Dentistrysupporting

confidence: 52%

Lasers in Periodontics: A Review of the Literature

Cobb

2006

Journal of Periodontology

307

225

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“…Furthermore, it consents to have less postoperative pain, inflammation, and as one of the best benefits, wound healing by secondary intention thanks to the coagulation capacity [5][6][7]. Oral biopsy performed by laser permits to not use suture that can delay healing by plaque increasing [8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of wound healing and postoperative pain after oral mucosa laser biopsy with the aid of compound with chlorhexidine and sodium hyaluronate: a randomized double blind clinical trial

et al. 2018

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Objectives The aim of this study is to evaluate secondary intention healing process and postoperative pain of oral soft tissues after laser surgery with the use of a compound containing chlorhexidine and sodium hyaluronate. Materials and methods This double-blind, randomized clinical study included 56 patients affected by benign oral lesions and subjected to excisional biopsy with diode laser and randomly divided into three groups. Study group (SG) received 0.2% chlorhexidine digluconate and 0.2% sodium hyaluronate treatment; control group (CG) received 0.2% chlorhexidine digluconate; and placebo group (PG) followed the same protocol, taking a neutral solution having the same organoleptic characteristics. Wound healing was evaluated using percentage healing index (PHI). Numeric rating scale (NRS) was used to evaluate postoperative pain. Results PHI (T1 = 7 days) was 67.25% for SG, 58.67% for CG, and 54.55% for PG. PHI (T2 = 14 days) was 94.35% for SG, 77.79% for CG, and 78.98% for PG. A statistically significant difference was between the groups for PHI at T2 p = 0.001. No difference was detectable for pain index. Conclusions A solution containing sodium hyaluronate and chlorhexidine is a good support to increase wound healing by secondary intention after laser biopsy, but no differences were in postoperative perception of pain. Clinical relevance The use of the tested solution can be recommended after laser oral biopsies, to achieve a healing without suture. About the postoperative pain, the compound has not showed the same results and did not have measurable effects.

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“…Entre os recursos mais utilizados nas últimas décadas, a Laserterapia de baixa intensidade (LLLT) tem auxiliado a cicatrização de feridas por meio dos seus efeitos biomoduladores (BAXTER, 1994;ROMANOS, 1995;BISHT, 1999;TAM, 1999;CAPON, 2001WOODRUFF, 2004). No processo de reparação tecidual, a terapia fotônica interage em cada uma das três fases, proporcionando respostas positivas em cada uma delas (YU, 1997).…”

Section: Lista De Tabelasunclassified

“…A luz terapêutica corresponde a uma pequena porção do espectro de radiação eletromagnético total, e compreende os comprimentos de onda do visível ao infravermelho próximo (300 nm a 1.100 nm) (ANDERS, 1993 2000). Alguns estudos confirmam que, após realizar cirurgias com Lasers, em substituição ao bisturi metálico, existia uma maior síntese de colágeno e maior força de tensão dos tecidos (ROSSMANN et al, 2000;TAYLOR et al, 1997;ROMANOS et al, 1995;FINSTERBUSH et al, 1985). (SCHINDL, 2003;KIPSHIDZE et al, 2001;AMIR et al, 2000), contribuindo assim para a maior atividade na cicatrização de úlceras na pele devido a um maior fluxo sanguíneo local.…”

Section: O Laser Terapêutico De Baixa Intensidadeunclassified

Fotobiomodulação comparativa entre o laser e LED de baixa intensidade na angiogênese de feridas cutâneas de ratos

Corazza¹

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Emitting Diodes -(LEDs) são uma fonte de luz que estão sendo introduzidas comercialmente, mas com discreta base científica nesta modalidade fototerapêutica. O presente estudo comparou os efeitos angiogênicos da luz Laser coerente e colimada à luz LED ausente de coerência e colimação em feridas induzidas em ratos, com fluências diferentes. O modelo experimental consistia da indução de uma ferida circular no quadríceps de 120 ratos, utilizando um "punch" com 15 mm de diâmetro. Os animais foram divididos aleatoriamente em 5 grupos: Laser (660 nm) e LED (635 nm), sendo cada um ajustado a 5 J/cm 2 e 20 J/cm 2 , além do Controle. Após 6 horas da indução das feridas, os grupos tratados recebiam aplicação pontual de contato, e irradiados a cada 24 horas. A angiogênese foi analisada por meio da histomorfometria (H.E), e a contração das feridas pelo Software de Planimetria, sendo estudados os resultados no 3º, 7º, 14º e 21º dias pós-lesão. Os achados da análise histológica no 3º dia foram determinantes para induzir uma grande eficiência na proliferação de vasos sanguíneos dos grupos tratados em relação ao controle, demonstrando uma taxa próxima da constante no 7º dia, e com discreto aumento no 14º dia, porém com destaque para a tecnologia LED a 5 J/cm 2 (p≤0,05). No 21º dia, os grupos fototratados com fluência de 5 J/cm² apresentavam valores estatísticos com maior eficiência na angiogênese quando comparados com o grupo Laser a 20 J/cm², sugerindo que fluências elevadas podem induzir um processo do tipo saturação. Não ocorreu diferença da neovascularização no centro e nas margens da ferida (p≤0,05), sugerindo que ocorria uma fotobiomodulação de toda a lesão, favorecendo o crescimento homogêneo dos vasos sanguíneos. Tanto o Laser quanto o LED não apresentaram resultados significativos na redução da área das feridas. As fototerapias a Laser e LED de baixa intensidade sugeriram que a coerência e a colimação não eram fatores decisivos para induzir alterações nas funções celulares, e sim a banda de absorção do espectro eletromagnético. Ambas as fonte de luz vermelha ajustadas a fluências de 5 J/cm² podem demonstrar resultados expressivos no estímulo angiogênico em pele lesada.Palavras-chave: angiogênese, contração de feridas, cicatrização, Diodos Emissores de Luz (LEDs), Laserterapia de Baixa Intensidade (LLLT), histomorfometria. ABSTRACT CORAZZA, A. V. (2005). Comparative fotobiomodulation between the LED and lowintensity laser in the angiogenisis of skin wounds in rats.The Light Emitting Diodes (LEDs) are a source of light that have been commercially introduced, but still with a lack in its scientific basis in this phototherapeutic modality. The present study compared the angiogenics effects of the laser and LED illumination in induced wounds in rat, with fluencies different. The experimental model consisted of the induction of a circular wound on the quadriceps of 120 rats, using a "punch" with 15 mm diameter. Animals were divided randomyzed in 5 groups: Laser and LED each device with a dosage of 5 J/cm² and 20 J/cm², and Con...

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A Comparative Histological Study of Wound Healing following Nd:YAG Laser with Different Energy Parameters and Conventional Surgical Incision in Rat Skin

Cited by 20 publications

References 14 publications

Lasers in Periodontics: A Review of the Literature

Lasers in Periodontics: A Review of the Literature

Evaluation of wound healing and postoperative pain after oral mucosa laser biopsy with the aid of compound with chlorhexidine and sodium hyaluronate: a randomized double blind clinical trial

Fotobiomodulação comparativa entre o laser e LED de baixa intensidade na angiogênese de feridas cutâneas de ratos

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