This study showed a slower wound healing in the high-energy lased tissues. A similar healing in the low-energy lased tissues and in the incisions with the conventional scalpel was observed. The differences in the distribution of matrix proteins during healing and the coagulation of the tissues, which were exposed to low-energy laser treatment, might be the explanation for the minimal scarring, contraction, and pigmentation of the lased tissues as compared to conventional incisions.

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Wound healing following the use of Nd:YAG laser with different frequencies and energy parameters (20 pps and 1.75 W/30 pps and 3.0 W), and the conventional scalpel incision were studied over a period of 4, 7, 14, 21, and 28 days in the rat skin. The low-energy laser wounds could not be significantly differentiated from the conventional incisions although less damage and inflammatory reaction, increased matrix production, and only a little wound contraction could be demonstrated. In the high-energy lased tissues extensive damage and an increased inflammatory reaction were present. The low-energy Nd:YAG and scalpel incisions established a normal wound healing without scar tissue formation compared to the high-energy Nd:YAG, where the necrosis was higher.

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