A comparative overview of the sperm centriolar complex in mammals and birds: Variations on a theme

Soley, John Thomson

doi:10.1016/j.anireprosci.2016.02.006

Cited by 7 publications

(6 citation statements)

References 61 publications

(119 reference statements)

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“…Meanwhile, aplasia may also be the cause of the separation of the heads and tails of sperm because of an abnormal structure of the implantation fossa and/or the basal body [7]. Soley [24] believed that abnormal locations of the vacuoles and incomplete mitochondria can also physically prevent the formation of a normal head-neck junction. e droplets attached to the proximal site of the sperm tail can be misrecognised as oligozoospermia or pinhead-like sperm in some cases [25].…”

Section: Candidate Genes Of As Defects Can Bementioning

confidence: 99%

“…Both the unique morphology and genetic variation of AS sperm subtypes may affect the development failure in embryos (shown in Table 2 and Figure 1): the complete centrosome/centrioles of the sperm are important for embryonic development [24,50]. Galotto et al [51] and Hart [44] stressed the essential role of sperm centrioles in the early development of the embryo, such as migration of pronuclei, completion of the fertilization, and stimulating the first cleavage of zygote.…”

Section: The Outcomes Of Icsi Can Be Predicted By As Subtypesmentioning

confidence: 99%

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Beyond Acephalic Spermatozoa: The Complexity of Intracytoplasmic Sperm Injection Outcomes

Nie¹,

Tang²,

Qin³

2020

BioMed Research International

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This review analyses the genetic mechanisms of acephalic spermatozoa (AS) defects, which are associated with primary infertility in men. Several target genes of headless sperms have been identified but intracytoplasmic sperm injection (ICSI) outcomes are complex. Based on electron microscopic observations, broken points of the sperm neck are AS defects that are based on various genes that can be classified into three subtypes: HOOK1, SUN5, and PMFBP1 genes of subtype II; TSGA10 and BRDT genes of subgroup III, while the genetic mechanism(s) and aetiology of AS defects of subtype I have not been described and remain to be explored. Interestingly, all AS sperm of subtype II achieved better ICSI outcomes than other subtypes, resulting in clinical pregnancies and live births. For subtype III, the failure of clinical pregnancy can be explained by the defects of paternal centrioles that arrest embryonic development; for subtype I, this was due to a lack of a distal centriole. Consequently, the embryo quality and potential ICSI results of AS defects can be predicted by the subtypes of AS defects. However, this conclusion with regard to ICSI outcomes based on subtypes still needs further research, while the existence of quality of oocyte and implantation failure in women cannot be ignored.

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Section: Candidate Genes Of As Defects Can Bementioning

confidence: 99%

Section: The Outcomes Of Icsi Can Be Predicted By As Subtypesmentioning

confidence: 99%

Beyond Acephalic Spermatozoa: The Complexity of Intracytoplasmic Sperm Injection Outcomes

Nie¹,

Tang²,

Qin³

2020

BioMed Research International

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“…For example, while in neurons basal bodies are surrounded by rootlets ( Figure 1A, B) that connect them to the cytoplasmic membrane and are important for ciliary base stability 30 ; in spermatids, basal bodies are attached to the nuclear envelope, which may provide similar properties ( Figure S2C). Rootlets are also found in other ciliated cells, such as mechanosensory neurons in C. elegans and respiratory epithelial cells in mouse 31,32 , while the attachment of the ciliary base to the nucleus is also found in sperm cells of many other multicellular organisms 20,71 . Interestingly, we observed that SAS4, a known component of the basal body wall, also localises to neuronal rootlets ( Figure 2A, B, E, and S3D), suggesting that core basal body proteins may gain new functions in specific tissues.…”

Section: Cellular-and Tissue-specific Characteristics Influencing Cilmentioning

confidence: 99%

Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity

et al. 2018

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Cilia are evolutionarily conserved structures with many sensory and motility-related functions. The ciliary base, composed of the basal body and the transition zone, is critical for cilia assembly and function, but its contribution to cilia diversity remains unknown. Hence, we generated a high-resolution structural and biochemical atlas of the ciliary base of four functionally distinct neuronal and sperm cilia types within an organism, Drosophila melanogaster. We uncovered a common scaffold and diverse structures associated with different localization of 15 evolutionarily conserved components. Furthermore, CEP290 (also known as NPHP6) is involved in the formation of highly diverse transition zone links. In addition, the cartwheel components SAS6 and ANA2 (also known as STIL) have an underappreciated role in basal body elongation, which depends on BLD10 (also known as CEP135). The differential expression of these cartwheel components contributes to diversity in basal body length. Our results offer a plausible explanation to how mutations in conserved ciliary base components lead to tissue-specific diseases.

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“…However, when we surveyed the original literature on rodent spermatozoan ultrastructure, we found that a proximal centriole was reported to be present in most rodents and in all three of the main rodent suborders ( Fig 1B, SFig 1-2 ). A proximal centriole was reported in all studied rodent species of suborder Hystricomorpha , which includes the guinea pig ( Cavia porcellus ) (Fawcett, 1965; Gordon and Bensch, 1968), chinchilla ( Chinchilla lanigera ) (Healey and Weir, 1970), cane rat ( Thryonomys swinderianus ) (Soley, 2016), agouti ( Dasyprocta aguti ) (Arroyo et al, 2017), Spix’s yellow-toothed cavy ( Galea spixii ) (Santos et al, 2014), and naked mole rat ( Heterocephalus glaber ) (Van Der Horst et al, 2011). A proximal centriole was also reported in the rodent species of suborder Sciuromorpha , which includes the Korean squirrel ( Tamias sibiricus ) (Lee and Park, 2011) and the flying squirrel ( Glaucomys volans ) (Hruban et al, 1971).…”

Section: Resultsmentioning

confidence: 99%

The Evolution of Centriole Degradation in Mouse Sperm

Khanal

Puente

Chandanayaka

et al. 2023

Preprint

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Centrioles are subcellular organelles with an evolutionarily conserved structure and a shock absorber-like function. In sperm, centrioles are found at the flagellum base and are essential for embryo development in basal animals. Yet, sperm centrioles have evolved diverse forms, sometimes acting like a transmission system, as in cattle, and sometimes becoming dispensable, as in house mice. How the essential sperm centriole evolved to become dispensable in some organisms is unclear. Here, we test the hypothesis that this transition occurred through a cascade of evolutionary changes to the proteins, structure, and function of sperm centrioles and was possibly driven by sperm competition. We found that the last steps in this cascade are associated with a change in the primary structure of the centriolar luminal protein FAM161A in rodents. This information provides the first insight into the molecular mechanisms and adaptive evolution underlying a major evolutionary transition within the internal structure of the mammalian sperm neck.

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A comparative overview of the sperm centriolar complex in mammals and birds: Variations on a theme

Cited by 7 publications

References 61 publications

Beyond Acephalic Spermatozoa: The Complexity of Intracytoplasmic Sperm Injection Outcomes

Beyond Acephalic Spermatozoa: The Complexity of Intracytoplasmic Sperm Injection Outcomes

Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity

The Evolution of Centriole Degradation in Mouse Sperm

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