A Comparative pharmacological study on moxidectin and propolis ointment in rabbits naturally infested with Psoroptes cuniculi

Dakroury, M.F. El; Darwish, Ashraf

doi:10.33899/ijvs.2021.128171.1560

Cited by 3 publications

(3 citation statements)

References 23 publications

(42 reference statements)

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“…Regarding the evaluation of the estimated hormones as biomarkers for the disease, the data illustrated in table (3) suggested cortisol, GH, T3, and T4 as good markers for trypanosomiasis. This agreed with previous results that referred to cortisol as a biomarker for parasitic infection (mange) in rabbits and for tracking its treatment [25,26] .…”

Section: Discussionsupporting

confidence: 92%

Hormonal changes in Trypanosoma evansi-infected Rattus norvegicus: An approach to understand host-parasite interaction

Mohammed¹,

Darwish²,

Mohamed

2022

Parasitologists United Journal

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Background: Several studies were conducted on T. evansi infections in camels, but its pathogenesis is still mysterious especially in association with hormonal and infertility problems. Objective: The present research aimed to monitor the endocrine changes associated with T. evansi infection and its relation to immunity. Material and Methods: Twenty-four rats were used, four of them were considered the control group (CG), and the others were infected with T. evansi (IG). Blood samples were collected from CG at 0 day, while blood samples and testicular specimens were collected from IG on the 7 th , 14 th , 21 st , 28 th , and 35 th day (4 rats each time period). Cytokines, hormones, minerals, and electrolytes were measured, and the testicular specimens were sectioned, stained, and microscopically examined. Results: There was a significant increase in the pro-inflammatory cytokines accompanied by significant (P˂0.05) hypercortisolemia, increased growth hormone (GH) and thyroid stimulating hormone (TSH) levels, hypothyroidism, hypoinsulinemia, decreased testosterone, minerals, and electrolytes concentrations. Pro-inflammatory cytokines positively correlated with cortisol, growth hormone, and TSH and negatively correlated with T3, T4, insulin, and testosterone. The measured hormones yielded good values of sensitivity, specificity, and accuracy rate. The histopathological examination of the testicular tissue showed degeneration and necrosis of the spermatocytes and seminiferous tubules and hyperplasia of the interstitial tissue with edema, congestion, and infiltration. Conclusion:The recorded immunological changes during trypanosomiasis are strongly associated with the hormonal changes and infertility, and decreased minerals and electrolytes levels. Cortisol, T3, T4, and GH are proposed good indicators of trypanosomiasis.

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Section: Discussionsupporting

confidence: 92%

Hormonal changes in Trypanosoma evansi-infected Rattus norvegicus: An approach to understand host-parasite interaction

Mohammed¹,

Darwish²,

Mohamed

2022

Parasitologists United Journal

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“…The body mass ranges between 100-125 g (4) inch the metabolic rate to about 5% and help the animal stress resistance. Therefore, used in laboratory typical research, especially pharmacological audition of skin and sensitiveness (5,6). Adrenal glands are compound endocrine glands that play a key crucial role in the secretion of chemical substance substances and many types of hormones that help metabolism, fluid and electrolyte balance, and maintenance of life.…”

Section: Introductionmentioning

confidence: 99%

Comparative morphological and morphometrically study of the adrenal gland in adult males' squirrel (Sciurus anomalous) and hamster (Mesocricetus auratus)

Kadhim¹,

Khaleel²

2022

IJVS

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Given the physiological significance and the need for further physiological and morphological knowledge of the adrenal glands, the objectives of the current study were to compare morphometric data between the right and left adrenals of male squirrels and hamsters. The study was conducted on five squirrel males and five hamster males. The glands in both animals were removed and fixed in neutral formalin solution. It was found that the squirrel contains two brown-colored right and left adrenal glands connected anteriorly and medially to each cranial pole of the kidney, and the right adrenal gland had a longitudinal shape, while the left gland had an oval shape. Hamsters had two pairs of brown adrenal glands located anteriorly attached to each kidney's cranial pole. The right adrenal gland was round in shape, while the left was oval. The statistical results showed a significant difference between the left and right suitable adrenal glands in both animals, as well as a significant difference between the squirrel gland and the hamster gland, where it was found that the right and left squirrel glands are larger more significant, heavier, longer and thicker than the adrenal gland in hamsters after the following measures were adopted: weight, length, thickness, width, and size.

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“…The application of propolis is free from hepatic or kidney side effects (9). The Propolis mediated IONPs biosynthesis improved iron homeostasis in iron deficiency anemia (10).…”

Section: Introductionmentioning

confidence: 99%

The study of biogenic iron oxide nanoparticles effects on iron status in male rabbits infected with T. evansi

Al-Qayim¹,

Altaie²,

Ghali³

2021

IJVS

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The present study aimed to evaluate the effects of propolis-iron oxide nanoparticles in eliminating the T. evansi parasite and rehome stasis of deleterious iron status in experimentally infected rabbits. Twenty male rabbits were divided into equal four groups (n=5). the 1 st group as Control negative, 2 nd control positive, 3 rd trypanosomiasis and treated with propolis iron oxide nanoparticles, and 4 th trypanosomiasis and treated with diminazene,2 nd ,3 rd , and 4 th groups were inoculated with T. evansi, and were checked for the onset of parasitemia. After 15 of the onset of parasitemia 3 rd group was treated with propolis-iron-oxide nanoparticles 30 mg iron /kg BW, and 4 th group was treated with diminazene drug with a single dose 3.5 mg/kg BW. The result showed that experimentally infection with T. evansi caused a significant decrease of serum iron and ferritin and a significant increase in total iron-binding capacity and unsaturation iron-binding capacity, as well erythrocytes fragility, bilirubin totally and partially. Treatment with propolis-iron oxide nanoparticles improved iron status parameters to semi-normal values much better than diminazene drug, in addition, reduced the total bilirubin concentration and osmotic fragility of erythrocytes toward a normal state. It can be concluded that the propolis-iron oxide nanoparticles proved successfully rebalancing iron status and eliminating the parasite and making iron available.

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A Comparative pharmacological study on moxidectin and propolis ointment in rabbits naturally infested with Psoroptes cuniculi

Cited by 3 publications

References 23 publications

Hormonal changes in Trypanosoma evansi-infected Rattus norvegicus: An approach to understand host-parasite interaction

Hormonal changes in Trypanosoma evansi-infected Rattus norvegicus: An approach to understand host-parasite interaction

Comparative morphological and morphometrically study of the adrenal gland in adult males' squirrel (Sciurus anomalous) and hamster (Mesocricetus auratus)

The study of biogenic iron oxide nanoparticles effects on iron status in male rabbits infected with T. evansi

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