“…Several previous studies that have assessed the effects of EDTA gel as a coadjuvant in periodontal treatment focused on the root surface of human teeth extracted due to severe periodontitis. The purpose of these studies was to analyze the surface topography of periodontally affected human tooth roots after application of EDTA gel with different combinations of treatments (4,5,7,12,(16)(17)(18)29,30). The authors concluded that root surfaces treated with EDTA appeared to be more suitable for cellular colonization and subsequent connective tissue formation (4,5), and exhibited numerous dentinal tubules exposed by removal of the smear layer (7,12,16,17,29), and an intact collagenous matrix (18,30).…”