A Comparative Study between β-TCP Prepared by Solid State Reaction and by Aqueous Solution Precipitation: Application in Cements

Oliveira, Aline Pereira de; Motisuke, Mariana; Leal, Claudinete V.; Beppu, Marisa Masumi

doi:10.4028/www.scientific.net/kem.361-363.355

Cited by 8 publications

(4 citation statements)

References 6 publications

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“…CPCs solid phase, β-TCP, was synthesized by solid state reaction of a stoichiometric mixture of CaCO 3 (Synth, Brazil) and CaHPO 4 (Synth, Brazil) at 1050 °C 11,12 followed by ball milling during 48 hours 12 . The resulting powder was analyzed by laser diffraction (Mastersizer 2000) and presented mean particle size of 3.6 µm and granulometric distribution between 0.770 µm and 20.843 µm.…”

Section: Calcium Phosphate Cement (Cpc) and Scaffoldsmentioning

confidence: 99%

Scaffolds of calcium phosphate cement containing chitosan and gelatin

et al. 2013

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Calcium phosphate cements (CPCs) have potential to be used on repairing damaged bones due to their moldability, bioactivity and bioresorbability. These materials combine calcium orthophosphate powders with a liquid leading to a paste that hardens spontaneously at low temperatures. Hence, CPCs could be applied as scaffolds to support cell/tissue growth. This paper studies CPC scaffolds processing by foaming cement's liquid phase in which was added gelatin and chitosan. The former acted to increase the foam stability while the ladder acted as a foaming agent. Moreover, these polymers would enhance scaffold's biological properties by controlling material's total porosity and in vivo resorption. The method proposed led to scaffolds with 58.71% porosity with sizes ranging from 160 to 760 µm and compressive strength of 0.70MPa. After foaming, pores' size, distribution and interconnectivity changed significantly leading to a material that could be applied on bone regeneration since it would allow nutrient's transport, cell attachment and an increase in material degradation rate.

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Section: Calcium Phosphate Cement (Cpc) and Scaffoldsmentioning

confidence: 99%

Scaffolds of calcium phosphate cement containing chitosan and gelatin

et al. 2013

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“…Although various methods (e.g., solid state [9], wet precipitation [10], sol-gel [11], and spray drying [12]) have been reported to fabricate β-TCP materials, each method has some disadvantages that need to be overcome. For the solid-state method, the grinding process causes contamination, making it difficult to maintain a high purity for bioactivity [13].…”

Section: Introductionmentioning

confidence: 99%

Fabrication, Characterization and In Vitro Cytotoxicity of Mesoporous β-Tricalcium Phosphate Using the Spray Drying Method

et al. 2021

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Mesoporous beta tricalcium phosphate (β-TCP) has recently attracted significant interest as an artificial bone tissue in orthopedics. However, a scalable process is required to meet future demands. Spray drying is one of the potential synthesis methods owing to its low cost and scalable production. In this study, various mesoporous β-TCP powders were calcined in the range of 800 to 1100 °C, with particle sizes ranging from ~0.3 to ~1.8 μm, specific surface areas from ~16 to ~64 m2/g, and average pore sizes of 3 nm. Except for the 800 °C calcined powder, the other β-TCP powders (calcination temperatures of 900, 1000, and 1100 °C) exhibited no cytotoxicity. These results indicate that spray-dried mesoporous β-TCP powders were obtained. Finally, the corresponding formation mechanisms are discussed.

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“…Experimental details 2.1. Preparation and characterization of β-TCP and 45S5 bioglass powders β-TCP powder was synthesized via solid-state reaction as described elsewhere (Oliveira et al, 2008;Reno et al, 2014). Briefly, a 2:1 molar ratio mixture of CaHPO 4 (Synth, Brazil) and CaCO 3 (Synth, Brazil) was calcined at 1050 1C (EDG Inox Line/3000 3P/1200 1C, SP, Brazil) followed by milling in a horizontal ball mill (MA500, Marconi, Piracicaba, SP, Brazil) during 48 h (alumina milling media of 6 mm of diameter and ball/powder weight ratio of 10:1).…”

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Hierarchical structures of β-TCP/45S5 bioglass hybrid scaffolds prepared by gelcasting

Lopes

Magalhães

Gouveia

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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This paper investigates the microstructure and the mechanical properties of β-tricalcium phosphate (β-TCP) three-dimensional (3D) porous materials reinforced with 45S5 bioactive glass (BG). β-TCP and β-TCP/x%-BG scaffolds with interconnected pores networks, suitable for bone regeneration, were fabricated by gel-casting method. Mechanical properties, porosity, and morphological characteristics were evaluated by compressive strength test, scanning electron microscopy (SEM) and X-ray microtomography analysis, whereas the structures were fully explored by XRD, and Raman spectroscopy. To the best of our knowledge, this is the first time where the mechanism for understanding the effect of bioglass on the mechanical properties and microstruture of β-TCP/45S5-BG scaffolds has been systematically studied. The findings showed that ionic product lixiviated from 45S5 bioactive glass, rich in silicon species and sodium ion, catalyzes a phase transition from β-TCP to Si-TCP by replacement of phosphorus for silicon and contributes to the improvement of scaffolds mechanical properties. The compressive strength of β-TCP/5%-BG and β-TCP/7.5%-BG was improved around 200% in comparison to pure β-TCP. Osteoblast-like cells (MG 63) were exposed to the materials for 24h through the use of medium conditioned by β-tricalcium phosphate/bioactive glass. Cell viability was measured by MTT assay in the cells and the data obtained were submitted to ANOVA, Tukey׳s multiple comparison (p<0.05). The β-TCP/7.5-BG promoted an increase of cell proliferation. The results suggest that compositions and processing method studied may provide appropriate materials for tissue engineering.

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A Comparative Study between β-TCP Prepared by Solid State Reaction and by Aqueous Solution Precipitation: Application in Cements

Cited by 8 publications

References 6 publications

Scaffolds of calcium phosphate cement containing chitosan and gelatin

Scaffolds of calcium phosphate cement containing chitosan and gelatin

Fabrication, Characterization and In Vitro Cytotoxicity of Mesoporous β-Tricalcium Phosphate Using the Spray Drying Method

Hierarchical structures of β-TCP/45S5 bioglass hybrid scaffolds prepared by gelcasting

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