A Comparative Study of Antibiotic Sensitivity Pattern of Escherichia coli Isolated from Various Clinical Samples over a Period of 3 Years

Abstract

Escherichia coli, a gram negative bacillus, are present as a normal flora in human intestine. It is present in hospital environment and a common cause of nosocomial infection. In recent years it has shown resistance to various groups of antibiotics. Specimens like Urine, Pus, ET secretion; Sputum, etc were processed in Clinical Microbiology Laboratory for isolation and identification of E. coli. After identification E. coli was processed for Antibiotic Sensitivity testing using Kirby Bauer method. A total of 1237 samples had E. coli isolated. Out of 1237 E. coli isolated 540 (43.65%) were isolated from female patients while 697 (56.35%) were from male patients. Isolation was highest from Urine (50.69%) followed by Pus (36.14%) sample. Over all sensitivity of E. coli was as follow -Imipenam (64.63%), Amikacin (61.85%), Gentamicin (52.75%), Cotrimoxazole (37.90%), Cefepime (27.03%), Ciprofloxacin (26.62%), Cefotaxime (21.50%), Cefuroxime (12.20%), Cefoxitin (12.50%), Amoxicillin (10.54%), and Ceftazidime (4.57%). Every hospital needs to prepare antibiogram not only according to organisms but also according to clinical specimens so that empirical therapy can be started before culture and sensitivity investigation.

Antibiotic Susceptibility Pattern of Escherichia coli Isolated from Various Clinical Samples in Duhok City, Kurdistan Region of Iraq

“…In all other clinical specimens, including semen, ascetic, and cerebral spinal fluid specimens, E. coli showed high sensitivity to cefazolin, ertapenem, imipenem, levofloxacin, and nitrofurantoin. These results are in agreement with other research (26).…”