A comparative study of different methods of processing aortic homografts

Welch, William H.

doi:10.1136/thx.24.6.746

Cited by 11 publications

(4 citation statements)

References 10 publications

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“…Freeze-drying induced severe morphological changes in the tissues treated, confirming the results of others (King et al, 1967;Smith, 1967;Welch, 1969). Temperatures as low as -1000 C have been recommended (Sjostrand, 1967) during the drying stage in order to prevent the formation of ice crystals believed to be responsible for the large vacuoles found in the cusp matrix.…”

Section: Discussionsupporting

confidence: 81%

“…Gamma-radiation causes minimal adverse effects on human valve tissue (King, Heimbecker, and Trimble, 1967;Welch, 1969) and valves so treated may undergo fibroblastic infiltration with the formation of new endothelium (Little, 1970;Gibbons and Aliadine, 1970;Welch, 1970). Valve sterilization with gamma-radiation at 40 C was therefore studied and the observed changes were compared with those occurring in tissue sterilized with /8-propriolactone and stored in the freeze-dried state.…”

mentioning

confidence: 99%

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Gamma-radiation of heart valves at 4 C; a comparative study using techniques of histochemistry and electron and light microscopy

Donnelly

Aparicio

Dexter

et al. 1973

Thorax

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The optimal method of valve sterilization and storage is still not known. Pig aortic valve cusps have been studied using techniques of histochemistry, light microscopy, and electron microscopy, and the effects of gamma-radiation at 40 C have been determined. The effects of freezing, f3-propriolactone, and freeze-drying were also studied.Gamma-radiation at 40 C and storage at this temperature in a polyionic environment for up to six weeks appears to have minimal adverse effects. This technique of sterilization and storage has now been used in our clinical valve programme for over two years with encouraging results.

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Section: Discussionsupporting

confidence: 81%

mentioning

confidence: 99%

Gamma-radiation of heart valves at 4 C; a comparative study using techniques of histochemistry and electron and light microscopy

Donnelly

Aparicio

Dexter

et al. 1973

Thorax

View full text Add to dashboard Cite

show abstract

“…The contact areas of the cusps lie in a vertical plane at a level superior to that of the supporting metal ring. The microscopical anatomy of the pig aortic valve appears essentially similar to that of the human aortic valve (Welch, 1969). The anatomy of the pig valve differs from that of the normal human aortic valve in that one-third of the animal aortic ring is formed by cartilage and the base of the right coronary cusp is muscular (Binet, Duran, Carpentier, and Langlois, 1965).…”

Section: Resultsmentioning

confidence: 91%

“…It was hoped that a living autologous fascia lata valve would retain the advantages of the pig valve, while possessing a greater inherent durability by virtue of its living fibroblasts. However, recent reports (Lincoln et al, 1971;Welch, Potvliege, and Primo, 1971) reveal that the autologous fascia lata valve is imperfect. Depletion of fibroblasts and degenerative changes in the collagen of the transplanted fascia have been noted.…”

Section: Discuss:-onmentioning

confidence: 99%