A Comparative Study of Intrathecal Dexmedetomidine and Clonidine as an Adjuvant to Hyperbaric Bupivacaine in Surgeries for Fracture Femur and Tibia

Abstract

Introduction: Intrathecal α2-agonists are used as adjuvant drugs to local anesthetics. Study aimed to compare the effect of intrathecal dexmedetomidine and clonidine as an adjuvant to hyperbaric bupivacaine in patients undergoing surgery for fracture femur and tibia. Material and Methods: We carried a randomized double blind controlled study on patients undergoing elective surgery for fractures of femur and tibia. A total of 100 patients were included in the study and randomly allocated to two groups, Group C: received 2.5 ml of 0.5% hyperbaric bupivacaine with 50 mcg clonidine, Group D: received 2.5 ml of 0.5% hyperbaric bupivacaine with 5 mcg dexmedetomidine. Parameters assessed were level of sensory block and motor level. Results: The mean onset time for sensory block in Group C and Group D was 8.16±4.02 and 6.12±2.65 minutes respectively, with a statistically significant difference between both the groups. Whereas the mean onset of motor time was 12.32±4.85 and 8.12±3.98 minutes in Group C and Group D respectively, with a statistically significant difference between both the groups. Conclusion: Dexmedetomidine seems to be valuable adjuvant when regional anaesthesia is incorporated.

Comparative Study of Clonidine Vs Dexmedetomidine for Hemodynamic Stability and Postoperative Analgesia during Laproscopic Surgery

“…Various α 2 agonists are used in modern anaesthesia practice because of several benefits like sedation, analgesia, attenuation of stress response and reduction in anaesthetic drug requirement. 3,4,5 The two currently used drugs with dexmedetomidine are clonidine and dexmedetomidine with higher selectivity for α-2 receptor. Premedication with clonidine blunts the stress response to surgical stimuli and requirement of the narcotic and anaesthetic drug is also decreased.…”