A comparative study of serum lipid contents in pre and post IFN-alpha treated acute hepatitis C patients

Arain, Sadia Qamar; Talpur, Farah Naz; Channa, Naseem Aslam

doi:10.1186/s12944-015-0119-x

Cited by 13 publications

(11 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The palmitic and stearic acid in free form is significantly higher in hepatitis B patients. The FFA contain lipotoxic properties reported in the literature [ 36 ]. The saturated FFA’s, palmitic acid and stearic acid are more cytotoxic than monounsaturated FFAs.…”

Section: Discussionmentioning

confidence: 99%

Serum lipids as an indicator for the alteration of liver function in patients with hepatitis B

et al. 2018

Self Cite

View full text Add to dashboard Cite

BackgroundHepatitis B virus (HBV) exerts an intense impact on host lipid metabolism. Hence the aim of present study is to determine metabolic derangement that occurred in subjects suffering from hepatitis B patients.MethodsThe fasting blood samples were collected from hepatitis B patients (n = 50) attended in Taluka hospital TandoAdam, Sindh with age and gender matched controls (n = 50). Serum lipid profile and fatty acid (FA) composition were analyzed by micro-lab and gas chromatography.ResultsThe hepatitis B patients have significantly lower level (p < 0.01) of lipid profile including total cholesterol (TC), triacylglyceride (TAG), high density lipoprotein-C (HDL-C) very low density lipoprotein-cholesterol (VLDL-C), low density lipoprotein-cholesterol (LDL-C), and total lipid (TL) in comparison to controls, indicating hypolipidemia in patients. The result of total FA composition of HBV patients in comparison to controls reveal that myristic, palmitic, docosahexaenoic acids were significantly (p < 0.05) higher, while linoleic, eicosatrienoic, arachidonic, eicosapentaenoic acids were lower in HBV patients in comparison to controls. The elongase, ∆5 and ∆6-desaturase enzymes activities were found lower, while ∆9-desaturase activity was higher in hepatitis B patients as compared to controls, which indicates the impaired lipid metabolism.ConclusionThe serum saturated fatty acid (SFA) and monounsaturated fatty acid (MUFA) were increased while polyunsaturated fatty acid (PUFA) was reduced in both total and free form in hepatitis B patients due to altered activities of enzyme desaturases with impaired PUFA metabolism and non-enzymatic oxidation.Electronic supplementary materialThe online version of this article (10.1186/s12944-018-0683-y) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Serum lipids as an indicator for the alteration of liver function in patients with hepatitis B

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…The palmitic, palmitoleic, stearic and myristoleic acids are elevated in free form in HBV-cirrhosis patients. Most of the literature has focused on the lipotoxic properties of FFAs [ 49 , 50 ]. Malhi et al [ 51 ] indicated that FFAs can have diverse cellular and metabolic effects particularly stearic acid is more cytotoxic than palmitic acid.…”

Section: Discussionmentioning

confidence: 99%

Serum lipid profile as a marker of liver impairment in hepatitis B Cirrhosis patients

et al. 2017

Self Cite

View full text Add to dashboard Cite

BackgroundChronic HBV infection is a major cause of Cirrhosis and an important risk factor to develop hepatocellular carcinoma. The study is conducted to find out the changes in the lipid metabolism of HBV-cirrhosis patients.MethodsIn the present study, serum lipid profiles of patients with HBV-cirrhosis were assessed by utilizing micro-lab and gas chromatography, while risk factors for transmission of HBV-cirrhosis studied through the standard questionnaire.ResultsThe epidemiological and etiological risk factors strongly associated with HBV-cirrhosis patients compared to controls, included as family history, shave from the barber, blood transfusion (without proper screening), mutual sharing of household contents, positive surgery history, and dental treatment. The HBV-cirrhosis patients have significantly lower level (p < 0.001) of lipid profile including total cholesterol (96.65 mg/dl), TAG (82.85 mg/dl), VLDL-C (16.57 mg/dl), LDL-C (68.27 mg/dl), HDL-C (27 mg/dl) and total lipid (424.76 mg/dl) in comparison to controls, indicating hypolipidemia in patients. The MELD score indicated mild prognostic values of the hepatic function for the study group. The result of total fatty acid composition of HBV-cirrhotic patients with comparison of control subjects reveals that palmitic (24.54 g/100 g) and palmitoleic acid (4.65 g/100 g) were significantly (p < 0.05) higher whereas eicosatrienoic (0.09 g/100 g), arachidonic (3.57 g/100 g), linoleic (22.75 g/100 g) and α-linolenic acid (0.12 g/100 g) were significantly lower. Marker for stearoyl-CoA desaturase (SCD = ∆9-desaturase) activity i.e. palmitoleic: palmitic (0.2) and oleic: stearic acid (1.5) ratios, originated higher in HBV-cirrhotic patients, while PUFA: SFA (0.6) was lower in HBV-cirrhosis patients as compared with control subjects. The serum SFA and MUFA were increased while PUFA were reduced in both total and free form.ConclusionPresent study concluded that hypolipidemia observed in HBV-cirrhosis patients, MELD were found to be independent predictors of survival and alteration in fatty acid composition, possibly due to impairment in fatty acid metabolism by enzymatic elongation and desaturation.Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-017-0437-2) contains supplementary material, which is available to authorized users.

show abstract

“…The HCV lipo‐viral particles contain increased levels of apoC‐III that may inhibit the activity of lipoprotein lipase, disturbing the intravascular catabolism of TG‐rich lipoproteins . Moreover, the profiles of serum lipids, such as TG, Chol, LDL‐C and HDL‐C, were reduced in patients with acute and chronic HCV infection . An increasing body of evidence demonstrated that HCV may modulate lipid metabolism and promote the synthesis of saturated fatty acids by controlling the enzymes in the lipid synthesis pathway .…”

Section: Chronic Hepatitis Viral Infection and Lipid Profilesmentioning

confidence: 99%

Systematic review: chronic viral hepatitis and metabolic derangement

Wang

Cheng

Kao

2019

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Summary Background The liver has a critical role in the metabolism of glucose and lipids. Chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection leads to a spectrum of liver disease including chronic hepatitis, cirrhosis and hepatocellular carcinoma. Metabolic syndrome (MetS) has a rising incidence owing to an epidemic of type 2 diabetes mellitus (T2DM) and obesity. Non‐alcoholic fatty liver disease is a liver manifestation of MetS and has become the most common cause of chronic liver disease worldwide. Aim To summarise the interplay among hepatitis viruses, MetS and its components. Methods We searched the literature about HBV, HCV infection, MetS, fatty liver and its components from PubMed. Results With respect to the viral replication cycle, lipids are important mediators between viral entry and hepatocyte in HCV infection, but not in HBV infection. Thus, HCV infection is inversely associated with hyperlipidaemia and lipid rebound occurs following sustained viral response induced by interferon‐based therapy or direct antiviral agents. In addition, HCV infection is positively associated with insulin resistance, hepatic steatosis, MetS and the risk of T2DM and atherosclerosis. In contrast, HBV infection may protect infected subjects from the development of MetS and hepatic steatosis. Accumulating evidence suggests that HBV infection is inversely associated with lipid metabolism, and exhibits no conclusive association with insulin resistance or the risk of T2DM and arteriosclerosis. Conclusions In patients with viral hepatitis and concurrent metabolic diseases, a multidisciplinary approach should be given rather than simply antiviral treatment.

show abstract

A comparative study of serum lipid contents in pre and post IFN-alpha treated acute hepatitis C patients

Cited by 13 publications

References 35 publications

Serum lipids as an indicator for the alteration of liver function in patients with hepatitis B

Serum lipids as an indicator for the alteration of liver function in patients with hepatitis B

Serum lipid profile as a marker of liver impairment in hepatitis B Cirrhosis patients

Systematic review: chronic viral hepatitis and metabolic derangement

Contact Info

Product

Resources

About