A Comparative Study of Serum Creatinine and Uric Acid Levels in Subclinical and Overt Hypothyroidism Patients

Bhutal, Mahantesh; Mannangi, Neela; M, Kavitha M; Pujar, Sunitha H.

doi:10.18410/jebmh/2020/174

Cited by 1 publication

(2 citation statements)

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“…The present study concludes that there is signicant increase in serum creatinine levels in subclinical hypothyroid subjects as compared to healthy controls. Similar changes in serum creatinine with hypothyroidism have been evaluated in (18,19,(31)(32)(33)(34)(35)(36)(37)(38)(39) support of the present study.…”

Section: Discussionsupporting

confidence: 86%

“…Our study shows that serum fT , serum fT level were less and 3 4 serum TSH was more in subjects with subclinical hypothyroidism than healthy controls and difference was statistically highly signicant (P<0.0001). A similar trend was reported in a study done by Bhutal MB et al (2020) which also suggest that serum ft , serum fT levels were signicantly lower 3 4 and serum TSH was signicantly higher in subjects with subclinical hypothyroidism as compared to normal healthy (18) controls.…”

Section: Discussionsupporting

confidence: 83%

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Evaluation of Serum Creatinine Level in Subclinical Hypothyroidism

Thadani

Kumawat

Mahawar

et al. 2021

Global Journal for Research Analysis

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Background: Hypothyroidism is a common endocrinal disorder caused by insufcient production of thyroid hormones. Subclinical hypothyroidism (SCH) can be dened as a state of high serum thyroid stimulating hormone (TSH) levels (less than 10µIU/ml) with normal serum free thyroxine (fT ) and triiodothyronine (fT ) levels in 4 3 the presence or absence of symptoms. Creatinine is a chemical waste product that is produced by muscle metabolism. Creatinine is produced from creatine, a molecule of major importance for energy production in muscles. Thyroid dysfunction can affect renal physiology and development, and on the other hand, kidney disorders can inuence thyroid function. This study was aimed to nd out the status of serum fT , fT ,TSH and serum creatinine levels in subclinical hypothyroid cases and 3 4 healthy controls. Materials and Methods: The present study is descriptive case control study, was conducted in the Department of Biochemistry, J.L.N. Medical College and Associated group of Hospitals, Ajmer (Raj.). 130 cases of subclinical hypothyroidism attending Medical OPD of J.L.N. Hospitals were included and 50 age-sex matched euthyroid controls were selected. Results: The mean serum creatinine levels were found to be signicantly high in subclinical hypothyroid cases(0.99 + 0.19 mg%) as compared to healthy controls (0.75 + 0.15 mg%), (p<0.0001). Conclusion: Serum creatinine can be used as a biomarker for early detection of subclinical hypothyroidism in general population to prevent the morbidity and mortality which are associated with hypothyroidism. Early diagnosis and intervention of subclinical hypothyroid and their cluster of risk factor can prevent the renal dysfunction.

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