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Introduction and Aim:  Psoriasis is one of the salient dermatological disorder and a chronic recurrent cutaneous disease.  Research shows that immunological cells and cytokines play a principal causative role for skin lesions and comorbid systemic effects in these patients. Like other autoimmune diseases, psoriasis is also a multifactorial disorder which is triggered either by injury, trauma, infections, medications, and psychological stress. Among the cytokines, hs-CRP acts as both inflammatory and cardiovascular marker. It is markedly increased in psoriasis patients, there by leading to subsequent co-morbidities in these patients. The aim of present study was to estimate inflammatory markers viz-TNF-?, IL-2, IFN-? and hs-CRP in psoriasis patients and controls and correlate these inflammatory markers with PASI score in psoriasis patients. Further to correlate hs-CRP with TNF-?, IL-2, IFN-? in these patients.   Materials and Methods: The study is conducted at a  tertiary level hospital and is designed as a Case Control study design conducted from January 2019 to January 2021. 110 subjects having diagnosed as psoriasis were included as cases and 110 controls. Inflammatory markers were estimated by ELISA method. Statistical analysis was done.   Results: The study showed that inflammatory markers in cases with psoriasis were significantly elevated when compared with controls. The inflammatory markers were proportionately altered from mild to severe in psoriasis patients but were not statistically significant. The hs-CRP showed negative significant correlation with IFN –?.   Conclusion: The present study concludes that the inflammatory markers are significantly increased in psoriasis patients, and this is correlated with PASI score. These simple biomarkers are of utmost importance in the clinical scenario for better treatment and prognosis and thereby reducing comorbidities in these patients.

Diabetes Mellitus (DM) is one of the most prevalent endocrine disorders in the world. It comprises a group of common metabolic disorders that share common phenotype of hyperglycemia. Impaired insulin release in Type 2DM is linked to various trace elements like iron, magnesium, chromium etc. Systemic iron overload leads to increased oxidative stress which results in abnormal glucose metabolism. The defects in insulin-producing and insulin-sensitive tissues caused by iron-dependent catalysis is via the Fenton's reaction of reactive oxygen radical species. Present study was undertaken to assess level of serum ferritin, free iron concentration, TIBC, transferrin saturation in type 2 Diabetes mellitus patients with good and poor glycaemic control and find out correlation between serum ferritin, free iron concentrations with glycaemic control. The study was conducted between January-August 2018 at SNMC & HSK Hospital Bagalkot. It's a case control study. Sample size included 120 subjects out of which 60 are diagnosed Type 2DM (cases) attending medicine OPD at SNMC & HSK, RC Bagalkot and 60 Healthy control appropriately matched for age and sex. The glucose parameters and serum iron, ferritin, TIBC, Transferrin saturation and Hb were high in cases compared to controls and was statistically significant. Serum iron and ferritin showed positive correlation with impaired glycaemic control. From this study it suggests that vital role of iron is metabolically deranged in diabetic patients.

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