Study of serum copper and zinc in diabetic retinopathy and its correlation with glycemic status

Ganiger, Arati; Swamy, K. Mallikarjuna; Prasad, Shankar; Mannangi, Neela; Gundalli, Shivanand

doi:10.5958/2394-6377.2016.00019.8

Cited by 5 publications

(3 citation statements)

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“…Low Zn levels may also favor Cu toxicity, as Zn competes with Cu and iron in the cell membrane (65). Cu, bound to glycated proteins, may blunt normal endothelium-derived relaxing factor (EDRF)-dependent relaxation of diabetic arteries, and provide a rationale for the use of transition metal chelators in the therapy of diabetic vasculopathy and neuropathy (63,66).…”

Section: Cu Metabolism Disturbances In Diabetic Patientsmentioning

confidence: 99%

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Serum levels of copper and zinc in diabetic retinopathy: Potential new therapeutic targets (Review)

et al. 2022

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Diabetic retinopathy (DR) is a microvascular disorder occurring due to the long-term effects of diabetes, leading to vision-threatening damage to the retina. The human body has an elaborate system for managing and regulating the number of key trace metals circulating in the blood and stored cells. Inadequate zinc (Zn) and concurrent excess of copper (Cu) levels are associated with an increased level of oxidative stress, which may aggravate the microvascular lesions in diabetes mellitus. Several studies have revealed a significantly lower serum Zn concentration and increased Cu levels in DR when compared with diabetic patients without retinopathy and normal controls. These abnormalities are correlated with the duration of diabetes and higher levels of HbA1C. Multiple pathological mechanisms are proposed to explain these changes including hyperzincuria associated with polyuria, glycosuria, and proteinuria in diabetic patients, as well as impaired absorption of Zn at the gastrointestinal level. Increased levels of free Cu ions may be attributed to glycation and the release of Cu ions from the Cu-binding sites of proteins. Zn supplements and selective Cu chelators may be useful to alleviate oxidative stress and prevent DR progression.

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Section: Cu Metabolism Disturbances In Diabetic Patientsmentioning

confidence: 99%

“…Zn is an inducer of gene and protein expression of metallothionein (MT), which is an effective antioxidant (67). Zn deficiency is associated with the progression of chronic disease states such as metabolic syndrome, diabetes, diabetic microvascular complications, and DR (6,66).…”

Section: Serum Cu and Zn Levels In Dr Vs Controls In Clinical Studiesmentioning

confidence: 99%

Serum levels of copper and zinc in diabetic retinopathy: Potential new therapeutic targets (Review)

et al. 2022

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“…Proliferative diabetic retinopathy is an advanced stage of diabetic retinopathy in which a major micro vascular complication of uncontrolled diabetic mellitus occurs 4 . It is one of the most important causes of blindness in many countries 5 .…”

Section: Introductionmentioning

confidence: 99%

Proteins level in Sera and Saliva of Type 2 Diabetic Iraqi Patients with and without Proliferative Retinopathy

Hasan¹,

Aburahma²,

Al-Kazaz³

2017

Orient. J. Chem

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Proteins play a central role in cell structure and function. The present study aimed to measure the changes in total protein [TP], albumin [A], globulin [G], and [A]/ [G] ratio in sera and saliva samples of type 2 diabetic patients with and without proliferative diabetic retinopathy (PDR). Meanwhile agarose electrophoresis was used to confirm such changes. Also it aimed to look for the possibility of using saliva as an alternative sample to serum as a diagnostic fluid. The results indicated that a significant increase was observed in serum [G], salivary [TP], [A], and [A]/ [G] ratio, p =0.000, p=0.041, p=0.04, p=0.001 respectively, while there was a significant decrease in serum [A]/ [G] ratio p=0.000 in patients without PDR compared to healthy control. Also, the results showed that there was a significant increase in serum [G], salivary [TP], [A], [G] and [A]/[G] ratio, p =0.000, p=0.000, p=0.000, p=0.000, p=0.037 respectively, while a significant decrease in serum [A]/[G] ratio p=0.000 was observed in patients with PDR compared to patients without PDR. Sera and salivary agarose gel electrophoresis fractionation indicated an increase in [TP] and [G], but the changes were more obvious in the levels of gamma globulin fractions where the higher values were noticed in the patients group with PDR. Sera [A] were slightly decreased while salivary [A] was slightly increased. The most obvious finding was the existence of a positive correlation between the changes in [TP], [A] and [G] of serum and saliva in all studied groups.

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High glucose induced inflammation is inhibited by copper chelation via rescuing mitochondrial fusion protein 2 in retinal pigment epithelial cells

Dhivya

Sulochana

Devi

2022

Cellular Signalling

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Study of serum copper and zinc in diabetic retinopathy and its correlation with glycemic status

Cited by 5 publications

References 0 publications

Serum levels of copper and zinc in diabetic retinopathy: Potential new therapeutic targets (Review)

Serum levels of copper and zinc in diabetic retinopathy: Potential new therapeutic targets (Review)

Proteins level in Sera and Saliva of Type 2 Diabetic Iraqi Patients with and without Proliferative Retinopathy

High glucose induced inflammation is inhibited by copper chelation via rescuing mitochondrial fusion protein 2 in retinal pigment epithelial cells

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