2016
DOI: 10.1007/s11517-016-1494-9
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A comparative study of strontium-substituted hydroxyapatite coating on implant’s osseointegration for osteopenic rats

Abstract: Surface modification techniques have been applied to generate titanium implant surfaces that promote osseointegration for the implants in cementless arthroplasty. However, its effect is not sufficient for osteoporotic bone. Strontium (Sr) promotes osteoblast proliferation and inhibits osteoclast proliferation and positively affects bone regeneration. The aim of this study was to confirm the effects of strontium-substituted hydroxyapatite (Sr-HA) coating via electrochemical deposition on implant's osseointegrat… Show more

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Cited by 46 publications
(28 citation statements)
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“…Sr also activates the CaR and downstream signaling pathways in osteoclasts, causing reduced osteoclast differentiation and decreased bone resorption. The in vitro study of MSCs' adhesion on the different surfaces revealed that the metabolic activity and cell proliferation on the Sr-HA surface were upregulated in the early stage, indicating that the Sr-HA coating has better biocompatibility than the roughened and HA surfaces, which is consistent with previous studies Lindahl et al, 2015;Tao et al, 2016a;2016b). Attachment, adhesion, and spreading in the early period of cell-material interaction are critical for modulating the capacity of a cell to proliferate and differentiate (Anselme, 2000).…”
Section: Discussionsupporting
confidence: 88%
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“…Sr also activates the CaR and downstream signaling pathways in osteoclasts, causing reduced osteoclast differentiation and decreased bone resorption. The in vitro study of MSCs' adhesion on the different surfaces revealed that the metabolic activity and cell proliferation on the Sr-HA surface were upregulated in the early stage, indicating that the Sr-HA coating has better biocompatibility than the roughened and HA surfaces, which is consistent with previous studies Lindahl et al, 2015;Tao et al, 2016a;2016b). Attachment, adhesion, and spreading in the early period of cell-material interaction are critical for modulating the capacity of a cell to proliferate and differentiate (Anselme, 2000).…”
Section: Discussionsupporting
confidence: 88%
“…In recent years, many studies have highlighted the fabrication of strontium-doped hydroxyapatite (Sr-HA) on roughened implant surfaces (Aina et al, 2013;Gao et al, 2016;Tao et al, 2016a). The electrochemical method is capable of depositing Sr into or onto HA to form rod-like HA crystallites with a hexagonal cross section and diameters of about 90 nm, similar to the structure of bone HA (Jiao and Wang, 2009).…”
Section: Introductionmentioning
confidence: 99%
“…14 of 17 studies 26 28 , 30 34 , 37 42 calculated the percentage of new bone area (BA) of peri-implants. No meta-analysis could be conducted due to the considerable heterogeneity.…”
Section: Resultsmentioning
confidence: 99%
“…Micro-computed tomography (micro-CT) evaluation was performed in seven of included studies 29 , 31 , 32 , 34 36 . In quantitative assessment, four studies 31 , 32 , 34 , 38 showed Sr-enhanced implants demonstrated stronger effect on all micro-CT parameters including bone volume per total volume (BV/TV), 3D bone distribution such as trabecular number (Tb.N), thickness (Tb.Th), and/or spacing (Tb.Sp) and/or the connective density (Conn.D) than control implants, while other three studies found no statistically significant changes in some parameters.…”
Section: Resultsmentioning
confidence: 99%
“…Tao et al also adopted Sr coating to improve the osteointegration of Ti and ceramic materials in OP and osteopenic rats. The work group identified a direct correlation between the percentage of Sr ions used for coating (range tested: 5%-20%) and implant osseointegration measured by microtomography, histology and mechanical tests [29]. Although experimental coating with Mg and Zn showed good results in terms of implant integration and fixation and bone formation, the group treated with 10% Sr coating had significantly higher values of tested parameters [30].…”
Section: Rat Modelmentioning
confidence: 99%