A comparative study of the clinicopathological significance of E-cadherin and catenins (α, β, γ) expression in the surgical management of oral tongue carcinoma

Abstract

Both E-cadherin and catenins were highly under-expressed in oral tongue carcinoma, metastatic lymph node, and recurrent tumour. gamma-catenin had predictive value for nodal metastasis. E-cadherin was, however, a more important prognostic factor for recurrence and survival.

Upregulation of vimentin and aberrant expression of E-cadherin/β-catenin complex in oral squamous cell carcinomas: correlation with the clinicopathological features and patient outcome

“…However, clinicopathological variables and tumour-specific molecular markers that can identify patients with the highest risk of local recurrence have yet to be defined. 16,[18][19][20][21][22][23][42][43][44][45][46][47][48][49] Vimentin, a mesenchymal cell marker, associates with components of the cytoskeleton and membrane adhesions. Studies of human epithelial carcinomas, such as breast cancer, hepatocellular carcinoma, colon carcinoma, and prostatic adenocarcinoma, have shown that vimentin expression can be correlated with tumour invasion and a poor prognosis.…”

“…The absence or low expression of E-cadherin or b-catenin was significantly associated with some clinicopathological parameters and with a poor prognosis in some publications, but not in others. [19][20][21][22][23][51][52][53][54] The reason for these contradictory results may be that the standard used to evaluate the immunostaining and the definition of reduced or overexpression is quite variable. Alternatively, the tumour cells in oral squamous cell carcinoma patients may exhibit a heterogeneous cell population with variable behaviour.…”

“…[9][10][11][12] Several studies of epithelial malignancies have shown that E-cadherin or b-catenin can have a transcriptional and regulatory role in invasion and metastasis and is associated with a poor outcome. [13][14][15][16][17][18][19][20][21][22][23] E-cadherin is a 120 kDa calcium-dependent transmembrane glycoprotein encoded by the CDH1 gene located on chromosome 16q21, and it is expressed in most epithelial cells. 18 E-cadherin has a major role in establishing cell polarity and in maintaining normal tissue architecture.…”

Oral squamous cell carcinoma: Review of prognostic and predictive factors

“…Several papers correlate poorer prognosis with primary tumor changes of CD44v9 phenotype, with lower expression of CD44v3, and especially with reduced expression of E-cadherin and P-cadherin. [77][78][79][80] E-cadherin down-regulation was attributed to promoter hypermethylation. 81 Additionally, nodal metastases were independently associated with decreased beta-catenin expression.…”

Carcinoma verrucoso de boca: análise das características clínica e microscópica, da expressão imuno-histoquímica e da hipermetilação do gene da E-caderina

“…Alguns estudos demonstraram que as alterações nas moléculas de adesão celular nos carcinomas espinocelulares 3,6,16,39,43,93,95,101 , principalmente aquelas associadas à Ecaderina 49,62,73,76,77,79,94,96 , são requisitos fundamentais para o processo de invasão e metástase, determinando um comportamento biológico mais agressivo e uma evolução clínica desfavorável para estes tumores.…”