A comparative study of the sarcopenia screening in older patients with interstitial lung disease

Abstract

Background The Asian Working Group for Sarcopenia 2019 (AWGS 2019) is the gold standard diagnostic criteria for sarcopenia in Asian populations. The calf circumference (CalF), the strength, assistance in walking, rising from a chair, climbing stairs, and falls (SARC-F) and the SARC-CalF questionnaires for sarcopenia screening have been used by AWGS 2019. The aim of this study was to assess accuracy of these three sarcopenia screening tools in patients with interstitial lung disease. Methods In this cross-sectional study, stable patients with interstitial lung disease were enrolled. The SARC-F, SARC-CalF, and CalF, used in patients with interstitial lung disease, were compared to the diagnostic criteria proposed by AWGS 2019. The accuracy of screening tools was compared using sensitivity and specificity. Moreover, areas under the receiver operating characteristic curves (AUC) were computed. Results Seventy eight patients were analyzed, and sarcopenia was identified in 25 (32.1%) patients with interstitial lung disease by the AWGS 2019 criteria. The sensitivity of the CalF was highest (96%) of the three screening tools, while the specificity was 60%. The sensitivity of SARC-F and SARC-CalF were 24% and 68%, while the specificity were 92% and 66%, respectively. The AUCs of CalF, SARC-F, and SARC-CalF in all patients were 0.78, 0.58, and 0.67, respectively. Conclusions The CalF is most suitable for screening sarcopenia in patients with interstitial lung disease, while SARC-F and SARC-CalF are not.

Sarcopenia in idiopathic pulmonary fibrosis: a prospective study exploring prevalence, associated factors and diagnostic approach

“…A recent study by Hanada et al . applied the diagnostic criteria of the Asian Working Group for Sarcopenia 2019 in a cohort of 78 patients with interstitial lung diseases (ILD) of Asian ethnicity and observed a prevalence of sarcopenia of 32%, higher than the one we observed in our cohort of patients with IPF at diagnosis [ 12 ]; however, these differences may be due to the different ethnicity of the study population (in our study all patients were Caucasian) and to the different underlying pulmonary disease. On the contrary, Bocchino et al .…”

“…Recent literature has evaluated the prevalence of dynapenia and sarcopenia in patients with fibrosing interstitial lung diseases at various stages [ 12 – 14 ].…”

Frequency and impact on clinical outcomes of sarcopenia in patients with idiopathic pulmonary fibrosis

“…Regarding interstitial lung disease (ILD), it is reported that sarcopenia was identified in 32.1% of Japanese patients with ILD. 19 In patients with IPF, the reported muscle assessments were the fat-free mass index, 20 ASMI, 21 and cross-sectional area of the erector spinae muscles. [22][23][24][25][26] A lower skeletal muscle mass is associated with lower quality of life and worse prognosis.…”

Deep Learning-Based Muscle Segmentation and Quantification of Full-Leg Plain Radiograph for Sarcopenia Screening in Patients Undergoing Total Knee Arthroplasty

“…To our knowledge, among all reported sarcopenia screening models, ours showed the highest performance (AUC 0.988, 95% CI 0.986-0.989) [25,33,51,52]. We have developed a pipeline involving both deep-learning-and machine-learning-based models, to take both radiographic images and patient baseline characteristics into consideration (which can be easily obtained in the preoperative clinical setting).…”