A Comparative Study of the Impact of Dietary Calcium Sources on Serum Calcium and Bone Reformation Using an Ovariectomized Sprague-Dawley Rat Model

Abstract

Osteoporosis is a multifactorial skeletal disease that is characterized by compromised bone strength predisposing a person to an increased risk of fracture. This ovariectomized (OVX) Sprague-Dawley rat model study measured the changes in serum calcium, as well as femur dimensions and mineral density, when consuming calcium carbonate, calcium gluconate and salmon bone calcium. Our results show that salmon bone calcium and to a lesser extent calcium gluconate showed a statistically significant increase in femur dimension and mineral density while calcium carbonate showed no impact on either bone parameter. Our results also show that none of the three calcium sources affected serum calcium levels after 8 weeks of treatment.

A Randomized, Blinded, Calcium-Carbonate Controlled Cross Over Study of Serum Calcium Levels 24 Hours After CalGotm Oral Supplementation in Post- Menopausal Women

“…Studies have shown that the intake of Collagen has a positive effect of increasing BMD in several in-vivo bone growth models [10]. CalGo™ has also shown an osteoinductive effect by increasing osteoblast activity in-vitro [11] and in-vivo [12].…”