A Comparative Study of the Surgically Relevant Mechanical Characteristics of the Topical Skin Adhesives

Singer, Adam J.; Perry, Larry

doi:10.1111/acem.12009

Cited by 22 publications

(15 citation statements)

References 11 publications

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“…Chit/FCat films showed better adhesion strength than well-known natural tissue adhesives such as chitosan (15 kPa) and fibrin (13.5 kPa) and similar values to synthetic tissue adhesives based on cyanoacrylate (12–40 kPa). Considering the advantages of Chit/FCat films such as sustainable and low-cost raw materials, no risk of disease transmission, we hypothesized that the films produced in this study are an excellent alternative to fibrin glue in tissue adhesive applications.…”

Section: Resultsmentioning

confidence: 99%

Adhesive and Antibacterial Films Based on Marine-Derived Fucoidan and Chitosan

Correia

Costa

Inácio

et al. 2022

ACS Sustainable Chem. Eng.

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Marine-derived polymers are environmentally friendly and sustainable biomaterials that have structural similarities with the main components of the extracellular matrix. Moreover, some marine polymers have specific bioactivity that can be transferred to the systems made of these biomolecules. Herein, we developed antibacterial adhesive films combining two marine polysaccharides, namely, fucoidan and chitosan. Fucoidan was functionalized with catechol groups (FCat) to improve its adhesive properties. This modification enhanced also the fucoidan antibacterial properties: while fucoidan is active against Gram-positive bacteria, FCat showed bactericidal activity against Gram-positive and Gram-negative bacteria. To improve the processability and mechanical properties, FCat was blended with chitosan and solvent-casted to obtain films. These films exhibited an adhesion strength similar to the one of clinically used natural adhesives and no cytotoxicity: fibroblastic cells attached and remained viable on the films. Altogether our results demonstrated that the developed antibacterial and adhesive films are a feasible alternative of cytotoxic synthetic adhesives used for soft tissue healing applications.

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Section: Resultsmentioning

confidence: 99%

Adhesive and Antibacterial Films Based on Marine-Derived Fucoidan and Chitosan

Correia

Costa

Inácio

et al. 2022

ACS Sustainable Chem. Eng.

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“…Similarly, 2OCA was found to be effective compared with sutures in another study [11]. Clinically relevant characteristics have also been evaluated for different skin adhesives that are presently being used routinely, and these adhesives were found suitable [12]. Moreover, in vivo evaluation helped establish the superiority of octyl-cyanoacrylate-based adhesives compared with adhesives that are butyl-cyanoacrylate-based [13].…”

Section: Introductionmentioning

confidence: 97%

Are Topical Skin Adhesives An Option For Wound Closure Following Musculoskeletal Oncology Surgery? A STROCSS-Compliant Observational Study

Chobpenthai

Poosiripinyo

Tuntarattanapong

et al. 2021

Preprint

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Background:2-octyl cyanoacrylate (2OCA) is a high-viscosity medical-grade tissue adhesive used routinely. However, no studies have evaluated its use in musculoskeletal oncology surgery. Methods:We enrolled 99 patients undergoing musculoskeletal oncology surgery. 2OCA was chosen for wound closure, and it was applied by a specific surgeon for all patients. Drying times for the adhesive were recorded, and photographs were obtained intra-operatively. Post-treatment follow-up constituted queries regarding pain level, and recording incisional dehiscence, wound infection, hematoma, and incisional bleeding. Data collection was performed post-operatively at 48 hours, 5–10 days, 14 days, and 30 days. Other adverse events were documented. Results:2OCA was applied to 110 incisions in 99 patients constituting 62 female patients and 37 male patients. The mean age of patients was 50.41 (±16.83) years; mean incision length was 10.24 (±5.7) cm; and the mean pain score using a visual analogue scale (VAS) was 2.37 on post-operative day 7. The mean drying time was 1.81 (±0.59) minutes; 91 (91%) patients reported excellent and superior satisfaction, and the remaining patients reported “good” (6%) and “fair” (2%) satisfaction. The percentage of dehiscence, hematoma, and keloid formation was considerably low. Conclusion:2OCA was safe in musculoskeletal oncology surgical incisions in this study. The incidence of post-operative adverse events was low. However, some patients developed a hematoma. Post-operative pain was low, and patient satisfaction was high. 2OCA can be a practical alternative to traditional suture closure for skin incisions after musculoskeletal surgery.

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“…[ 11 ] Clinically relevant characteristics have also been evaluated for different skin adhesives that are currently being used routinely, and these adhesives were found to be suitable. [ 12 ] Moreover, in vivo evaluation helped establish the superiority of octyl-cyanoacrylate-based adhesives compared to butyl-cyanoacrylate-based adhesives. [ 13 ] Hence, in oncology-related surgery, where wound healing could be an issue, TSAs may provide alternative support to achieve better and more rapid wound healing.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of 2-octyl cyanoacrylate skin adhesives following musculoskeletal oncology surgery

et al. 2021

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2-octyl cyanoacrylate (2OCA) is a high-viscosity medical-grade tissue adhesive that is routinely used. However, no studies have evaluated its use in musculoskeletal surgery. We enrolled 99 patients who underwent musculoskeletal surgery. 2OCA was chosen for wound closure and was performed by a specific surgeon for all patients. The drying times for the adhesive were recorded, and photographs were obtained intra-operatively. Posttreatment follow-up consisted of queries regarding pain level and recording incisional dehiscence, wound infection, hematoma, and incisional bleeding. Data collection was performed postoperatively at 48 hours, 5 to 10 days, 14 days, and 30 days. Other adverse events were documented. 2OCA was applied to 110 incisions in 99 patients, comprising 62 female and 37 male patients. The mean age of patients was 50.41 (±16.83) years; mean incision length was 10.24 (±5.7) cm, and the mean pain score using a visual analogue scale was 2.37 on a postoperative day 7. The mean drying time was 1.81 (±0.59) minutes; 91 (91%) patients reported excellent and superior satisfaction, and the remaining patients reported “good” (6%) and “fair” (2%) satisfaction. The percentages of dehiscence, hematoma and keloid formation were considerably low. In this study, 2OCA was safe for musculoskeletal oncology surgical incisions. The incidence of postoperative adverse events was low. However, some patients develop hematomas. Postoperative pain was low, and patient satisfaction was high. 2OCA can be a practical alternative to traditional suture closure for skin incisions after musculoskeletal surgery.

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A Comparative Study of the Surgically Relevant Mechanical Characteristics of the Topical Skin Adhesives

Cited by 22 publications

References 11 publications

Adhesive and Antibacterial Films Based on Marine-Derived Fucoidan and Chitosan

Adhesive and Antibacterial Films Based on Marine-Derived Fucoidan and Chitosan

Are Topical Skin Adhesives An Option For Wound Closure Following Musculoskeletal Oncology Surgery? A STROCSS-Compliant Observational Study

Outcomes of 2-octyl cyanoacrylate skin adhesives following musculoskeletal oncology surgery

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