A Comparative Study of Top-Down and Bottom-Up Carbon Nanodots and Their Interaction with Mercury Ions

Bruno, Federico; Sciortino, Alice; Buscarino, Gianpiero; Soriano, M. Laura; Ríos, Ángel; Cannas, Marco; Gelardi, F. M.; Messina, Fabrizio; Agnello, S.

doi:10.3390/nano11051265

Cited by 29 publications

(27 citation statements)

References 56 publications

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“…Nitrogen and phosphorus codoped CDs with long-wavelength emission have been synthesized and applied in sensing ClO − and cell imaging [ 22 ]. Bruno et al compared the interaction pathways with Hg 2+ ions of the CDs synthesized through the bottom-up and top-down approaches and provided a convenient view for utilizing bottom-up CDs as sensors [ 25 ]. Indeed, an alternative fluorescent sensor is still required for the selective and sensitive detection of Hg 2 + or ClO − ions.…”

Section: Introductionmentioning

confidence: 99%

One-Pot Hydrothermal Synthesis of Carbon Dots as Fluorescent Probes for the Determination of Mercuric and Hypochlorite Ions

Lee

Tang

et al. 2021

Nanomaterials

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Nitrogen and sulfur codoped carbon dots (NSCDs) were synthesized via a one-pot hydrothermal method, and citric acid, ethylenediamine, and methyl blue were used as precursors. The obtained NSCDs were spherical with an average size of 1.86 nm. The fluorescence emission spectra of the NSCDs were excitation independent and emitted blue fluorescence at 440 nm with an excitation wavelength at 350 nm. The quantum yield of the NSCDs was calculated to be 68.0%. The NSCDs could be constructed as fluorescent probes for highly selective and sensitive sensing mercuric (Hg2+) and hypochlorite (ClO−) ions. As the addition of Hg2+ or ClO− ions to the NSCDs, the fluorescence intensity was effectively quenched due to dynamic quenching. Under the optimal conditions, the linear response of the fluorescence intensity ranged from 0.7 μM to 15 μM with a detection limit of 0.54 μM and from 0.3 μM to 5.0 μM with a limit of detection of 0.29 μM for Hg2+ and ClO− ions, respectively. Finally, the proposed method was successfully used for quantifying Hg2+ and ClO− ions in spiked tap water samples.

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Section: Introductionmentioning

confidence: 99%

One-Pot Hydrothermal Synthesis of Carbon Dots as Fluorescent Probes for the Determination of Mercuric and Hypochlorite Ions

Lee

Tang

et al. 2021

Nanomaterials

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“…The top-down approach is based on converting a bulky precursor into small-sized (<10 nm) CDs. Several techniques could achieve this approach, including fragmentation using a laser 39 , selective oxidation of the bulk material using hydrogen peroxide 40 , 41 , as well as oxidation using a mixture of strong acids (H 2 SO 4 and HNO 3 ) 42 , 43 .…”

Section: Top-down Approachmentioning

confidence: 99%

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

Ahmad¹,

Aung²,

Widati³

et al. 2023

Nanotheranostics

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Fluorescent Carbon dots (CDs) derived from biologically active sources have shown enhanced activities compared to their precursors. With their prominent potentiality, these small-sized (<10nm) nanomaterials could be easily synthesized from organic sources either by bottom-up or green approach. Their sources could influence the functional groups present on the CDs surfaces. A crude source of organic molecules has been used to develop fluorescent CDs. In addition, pure organic molecules were also valuable in developing practical CDs. Physiologically responsive interaction of CDs with various cellular receptors is possible due to the robust functionalization on their surface. In this review, we studied various literatures from the past ten years that reported the potential application of carbon dots as alternatives in cancer chemotherapy. The selective cytotoxic nature of some of the CDs towards cancer cell lines suggests the role of surface functional groups towards selective interaction, which results in over-expressed proteins characteristic of cancer cell lines. It could be inferred that cheaply sourced CDs could selectively bind to overexpressed proteins in cancer cells with the ultimate effect of cell death induced by apoptosis. In most cases, CDs-induced apoptosis directly or indirectly follows the mitochondrial pathway. Therefore, these nanosized CDs could serve as alternatives to the current kinds of cancer treatments that are expensive and have numerous side effects.

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“…CNMs come in different sizes, morphology, curvature, and reactivity. The diverse members of this family ( Figure 2 ) have been discovered through the years since the 1960s [ 10 ], with new ones continuously being produced, thanks to top-down or bottom-up approaches [ 11 , 12 , 13 ]. A common feature is that they are mainly composed of carbon atoms that are typically sp 2 hybridized and that are arranged in a honeycomb lattice [ 14 ].…”

Section: Carbon Nanomaterials (Cnms)mentioning

confidence: 99%

Carbon Graphitization: Towards Greener Alternatives to Develop Nanomaterials for Targeted Drug Delivery

Marin

Marchesan

2022

Biomedicines

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Carbon nanomaterials have attracted great interest for their unique physico-chemical properties for various applications, including medicine and, in particular, drug delivery, to solve the most challenging unmet clinical needs. Graphitization is a process that has become very popular for their production or modification. However, traditional conditions are energy-demanding; thus, recent efforts have been devoted to the development of greener routes that require lower temperatures or that use waste or byproducts as a carbon source in order to be more sustainable. In this concise review, we analyze the progress made in the last five years in this area, as well as in their development as drug delivery agents, focusing on active targeting, and conclude with a perspective on the future of the field.

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A Comparative Study of Top-Down and Bottom-Up Carbon Nanodots and Their Interaction with Mercury Ions

Cited by 29 publications

References 56 publications

One-Pot Hydrothermal Synthesis of Carbon Dots as Fluorescent Probes for the Determination of Mercuric and Hypochlorite Ions

One-Pot Hydrothermal Synthesis of Carbon Dots as Fluorescent Probes for the Determination of Mercuric and Hypochlorite Ions

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

Carbon Graphitization: Towards Greener Alternatives to Develop Nanomaterials for Targeted Drug Delivery

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