A comparative study of ventrolateral and recurrent excitatory postsynaptic potentials in large pyramidal tract cells in the cat

Deschênes, Martin; Labelle, Andre ́; Landry, P.

doi:10.1016/0006-8993(79)90598-5

Cited by 47 publications

(3 citation statements)

References 16 publications

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“…This phenomenon was in contrast with recurrent e.p.s.p.s observed in adult cats (Takahashi et al 1967). As Deschenes et al (1979a) proposed, even if the recurrent e.p.s.p.s were evoked in the distal part of basal dendrites, it is possible to induce such phenomena by current injection depending on the site of penetration. We could not compare the effect of current injection on the cerebellar e.p.s.p.s in this neurone.…”

Section: Morphological Investigation Of Ptnsmentioning

confidence: 69%

“…Pyramidal stimulation was known to induce synaptic effects on p.t.n.s with or without antidromic impulses (Phillips, 1959;Stefanis & Jasper, 1964;Brooks & Asanuma, 1965;Takahashi et al 1967;Deschenes, Labelle & Landry, 1979a). As shown in Fig.…”

Section: Morphological Investigation Of Ptnsmentioning

confidence: 99%

“…Takahashi et al (1967) used a pulse current (about 100 ms duration) and we used a direct current. Another possibility might be that our electrode penetrated a cell where the current injection affected the distal part of basal dendrites, since recurrent e.p.s.p.s are suggested to be evoked at the distal part of basal dendrites (Deschenes et al 1979a).…”

Section: Electrophysiological Findingsmentioning

confidence: 99%

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Post‐natal development of pyramidal tract neurones in kittens.

Oka¹,

Samejima²,

Yamamoto³

1985

The Journal of Physiology

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SUMMARY1. The post-natal development of pyramidal tract neurones (p.t.n.s) was investigated in twenty-one barbiturate-anaesthetized kittens from birth to 28 days of age using a combination of electrophysiological and anatomical techniques.2. P.t.n. responses were recorded intracellularly as well as extracellularly with glass micropipettes filled with horseradish peroxidase (HRP) on stimulation of the medullary pyramid and cerebellar nuclei.3. Latency histograms of antidromic responses of p.t.n.s were compared at various ages. In the neonate, p.t.n.s were divided into two groups which were presumed to be analogous with fast and slow p.t.n.s in adult animals. During the first post-natal week, latency shortening was not conspicuous, but by the end of the second post-natal week, the faster group showed a marked decrease of latencies (up to around 10 ms at 14 days of age), while those of the slower group did not change so much. The slower group increased their conduction velocity during the third post-natal week (latencies up to around 18 ms). At the end of the fourth post-natal week, the distribution of antidromic latencies was in a narrower range, but the values were still longer than those reported in adult animals.4. Intracellular HRP staining revealed that apical dendrites of p.t.n.s spread fully to the pial surface even at birth. The somata of these neurones were characteristically covered with somatic appendages and development of the basal dendritic tree was immature in 0-1-day-old kittens. Basal dendrites developed nearly completely by 7 days, but somata were still covered with appendages. During the fourth post-natal week, these appendages disappeared almost completely. The sizes of the dendritic field, especially of apical dendrites, became larger in parallel with the development of cortical layers.5. From the morphological point of view, differentiation of fast and slow p.t.n.s was not clear until 28 days of age except in somatic volumes, which were already different in the first post-natal week. At the end of the fourth post-natal week, p.t.n.s with short antidromic latencies had a tendency to bear spines more sparsely over the secondary and tertiary dendritic surface in comparison with p.t.n.s with longer latencies.6. Intracortical axonal trajectories developed fairly well in the immature cerebral cortex, and the general pattern of ramification changed little during the first month * To whom reprint requests and correspondence should be addressed. 16PHY 363

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Section: Morphological Investigation Of Ptnsmentioning

confidence: 69%

Section: Morphological Investigation Of Ptnsmentioning

confidence: 99%

Section: Electrophysiological Findingsmentioning

confidence: 99%

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Post‐natal development of pyramidal tract neurones in kittens.

Oka¹,

Samejima²,

Yamamoto³

1985

The Journal of Physiology

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Thalamocortical synapses involving identified neurons in mouse primary somatosensory cortex: A terminal degeneration and golgi/EM study

Hersch

White

1981

J of Comparative Neurology

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Synapses involving thalamocortical afferents and hitherto unexamined neuron types of the posteromedial barrel subfield (PMBSF) of the mouse have been identified using a combined degeneration and Golgi/EM technique (Peters et al., '77). Degeneration of thalamocortical axon terminals was produced with electrolytic lesions of the nucleus ventralis posterior, pars lateralis thalami, and the nucleus posterior thalami. Four days after receiving lesions, the animals were perfused, and blocks of cortex containing the PMBSF were processed by the Golgi method. The blocks were tissue-chopped at 125 microns and examined with the light microscope. Sections containing neurons of interest were gold-toned and deimpregnated in preparation for electron microscopy (Fairén et al., '77). Portions of selected neurons contained in layers III-IV were serially thin-sectioned and examined with an electron microscope to determine if they were involved in synapses with degenerating thalamocortical axon terminals. Results showed thalamocortical synapses on the apical dendrites of five different sized pyramidal cells whose somata occurred in layers V and VI, and on dendrites of on spiny bitufted neuron and one non-spiny multipolar neuron with somata in layer V. A non-spiny bitufted neuron of layer IV which was not impregnated also received thalamocortical synapses. Although every neuron examined formed at least one thalamocortical synapse, some formed very few, whereas others formed many. Of the pyramidal cells, small layer V and VI pyramidal cells and a large deep layer V pyramidal cell were involved in small numbers of thalamocortical synapses, while a medium superficial layer V pyramidal cell and a large layer VI pyramidal cell each formed many. The spiny bitufted neuron formed a small number of thalamocortical synapses. The findings suggest that, whereas any type of neuron with a dendrite in layer IV likely receives some synaptic input from the thalamus, individual neurons were involved in very different quantities of thalamocortical synapses.

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Morphology of neurons in area 4γ of the cat's cortex studied with intracellular injection of HRP

Ghosh

Fyffe

Porter

1988

J of Comparative Neurology

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Neurons in laminae II, III, V, and VI of area 4 gamma of the cat motor cortex were studied following intracellular penetration with an HRP-filled micro-electrode. Antidromic and synaptic responses produced by stimulation of the cerebral peduncles and/or of the ventrolateral nucleus of the thalamus were investigated. Horseradish peroxidase was then iontophoresed into the same neurons to allow examination of their detailed morphology. The morphology of pyramidal neurons whose somata were located in a particular lamina was similar but differed from that of pyramidal neurons in other laminae. The modified pyramidal neurons of lamina II had a truncated apical dendrite or did not possess an obvious apical dendrite, even though the ascending dendritic branches were longer and more extensive than the "basal" branches. As was the case for the pyramidal cells in other laminae, the axons of these lamina II modified pyramidal cells descended toward the white matter; their somata were generally pyramidal in shape, and their dendrites were spiny. All pyramidal neurons except some of lamina VI had ascending dendrites which terminated in a tuft in lamina I, subpially. No intracortical collaterals were seen originating from the axons of lamina II or of lamina VI pyramidal neurons. Lamina III pyramidal neurons had extensive short and long axon collaterals which contributed synaptic boutons to all laminae of the cortex. Pyramidal neurons of lamina V had fewer axon collaterals whose synaptic boutons were restricted to laminae V and VI. All somata of pyramidal tract neurons (PRNs), identified by antidromic responses from peduncular stimulation, were located in lamina V, except for one which was located in lamina VI. Recurrent collaterals of pyramidal neurons were activated by peduncular stimulation. Recurrent excitatory postsynaptic potentials (epsps) could be evoked in fast PTNs, slow PTNs, other pyramidal neurons of lamina V, and pyramidal neurons of lamina VI at latencies between 1.3 and 6.25 msec. In some slow PTNs, a recurrent inhibitory postsynaptic potential of long duration was the predominant response. Stimulation of the ventrolateral nucleus of the thalamus resulted in epsps in pyramidal neurons of lamina III, V, and VI at latencies between 1.0 and 5.0 msec.

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A comparative study of ventrolateral and recurrent excitatory postsynaptic potentials in large pyramidal tract cells in the cat

Cited by 47 publications

References 16 publications

Post‐natal development of pyramidal tract neurones in kittens.

Post‐natal development of pyramidal tract neurones in kittens.

Thalamocortical synapses involving identified neurons in mouse primary somatosensory cortex: A terminal degeneration and golgi/EM study

Morphology of neurons in area 4γ of the cat's cortex studied with intracellular injection of HRP

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