The Palu River is one of the largest rivers in Central Sulawesi and acts as a tourist attraction and a mode of commercial economy for local communities. These activities contribute to the production of domestic wastewater that can be a pollutant for rivers and affect the survival of aquatic organisms. This research aims to determine the distribution of domestic wastewater on the Palu River by identifying the physical and chemical quality of the water. This research is quantitative by direct measurements in the field and by testing river water quality in the laboratory. Sampling used the grab sampling method at three location points, they are at the outlet, before the outlet (point I), and after the outlet (point II), carried out at two different times, in the morning and afternoon. The tested parameters consist of TSS, turbidity, temperature, pH, COD, BOD, DO, and oil and fat. Modeling the distribution of river water quality after being contaminated by domestic waste used by surfers 13. The results showed that at point I and point II, the overall parameters did not exceed the river water quality standards for class III, but at the outlet, oil, and fat failed (1.275 mg/L). Based on the sampling time, in the morning TSS and BOD were the only parameters that approached the limit for both point I (99 mg/L and 5.80 ppm) and point II (97 mg/L and 5.47 ppm). In the afternoon, the COD value was so close to the standard of 40 ppm (35.64 ppm), and TSS at the point I (247 mg/L) and point II (297 mg/L) excelled the safe limit but did not make it at the outlet (15 mg/L). The rest parameters remained at safe limits. Overall, the physical and chemical quality of the river at all sampling points for BOD, oil and fat, turbidity, and temperature parameters tended to be higher in the morning than in the afternoon, while COD, DO, TSS, and pH did reversely.