A Comparative Study on the Effect of Solvents on the Phytochemical Profile and Biological Potential of Ormocarpum Cochinchinense Auct. Non (Lour.) Merrill

Hepsibah, A. Hannah; Jothi, G.

doi:10.22159/ijpps.2017v9i1.15126

Cited by 8 publications

(7 citation statements)

References 15 publications

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“…In the current work, acetone extracts of Paecilomyces lilacinus and Metarhizium anisopliae were highly active against the tested bacterial strains and Candida albicans. This result is very promising and could be explained according to Hepsibah and Jothi (2017) who reported superior antibacterial activity of acetone extract over ethyl acetate one. The present findings are in coincidence with Lee et al (2005), they declared that a number of M. anisopliae strains and Paecilomyces spp.…”

Section: Discussionmentioning

confidence: 65%

Snailicidal, antimicrobial, antioxidant and anticancer activities of Beauveria bassiana, Metarhizium anisopliae and Paecilomyces lilacinus fungal extracts

Abdel–Wareth¹,

Ghareeb²,

Abdel‐Aziz³

et al. 2019

Egypt. J. of Aquatic Biolo. and Fish.

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Fungi are capable of producing a wide variety of secondary metabolites. Entomopathogenic fungi along with species which parasitize nematodes represent excellent candidates for bioactive compounds production. This study aimed at exploring the snailicidal, antimicrobial and antioxidant activities of ethyl acetate and acetone extracts of Beauveria bassiana, Metarhizium anisopliae and Paecilomyces lilacinus. Ethyl acetate and acetone extracts were prepared and tested against Biomphalaria alexandrina snails, their antioxidant and antimicrobial activities were also investigated. The anticancer activity of P. lilacinus acetone extract was tested on hepatocellular carcinoma (HepG2) cells. Acetone extract of P. lilacinus (LC 50 =120 ppm) was more toxic to B. alexandrina snails than that of B. bassiana (LC 50 = 231 ppm). Sublethal concentrations of both extracts adversely affected survival rate, histological pattern of digestive and hermaphrodite glands of the tested snails, besides their genotoxicity to DNA of snails. P. lilacinus acetone extract showed the highest antioxidant activity. Also, its antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans was high. Moreover, it was cytotoxic to HepG2 cells (IC 50 =2.81 µg/ml). GC/MS analysis indicated the presence of 37 compounds in B. bassiana acetone extract with 2-methylhept-2,6-dien-4-ol and 1,3-dimethoxy-2-(hydroxymethyl)-9h-xanthene as major compounds. While 48 compounds were identified in P. lilacinus acetone extract where hexadecanoic acid, methyl ester and 10, 13 octadecadienoic acid, methyl ester were the major compounds. In conclusion, B. bassiana and P. lilacinus are excellent sources of bioactive compounds which have multiple biological effects. Pomacea canaliculata (Maketon et al., 2009). Generally, diverse toxic metabolites have been described in several fungal biological control agents including Beauveria, Metarhizium and Pacilomyces (Vey et al., 2001), some of these metabolites have been found to possess antibiotic, fungicidal or insecticidal properties (

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Section: Discussionmentioning

confidence: 65%

Snailicidal, antimicrobial, antioxidant and anticancer activities of Beauveria bassiana, Metarhizium anisopliae and Paecilomyces lilacinus fungal extracts

Abdel–Wareth¹,

Ghareeb²,

Abdel‐Aziz³

et al. 2019

Egypt. J. of Aquatic Biolo. and Fish.

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“…The RPI% of the test rhizome extract with respect to the positive control was calculated by using the method of Hepsibah and Jothi [43] .…”

Section: Evaluation Of the Relative Percentage Inhibition (Rpi%)mentioning

confidence: 99%

Secondary Metabolites, Pharmacognostic and Therapeutic Activities of the Rhizome Extract of Curcuma longa Grown in South-West, Nigeria

S¹,

O²,

Anuoluwa³

et al. 2020

J Phytopharmacol

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Curcuma longa is an important plant with diverse medicinal properties. The aim of this study was to determine the chemical constituents and phenolic contents, ascorbic acid content, antioxidant, anti-arthritic and antibacterial potential of the rhizome extract of C. longa grown in South-West, Nigeria. GC-MS, UV-Visible Spectrophotometer, other established biochemical methods were used to investigate the rhizome extract. The GC-MS analysis revealed the presence of sixty ( 60) therapeutically active phytochemicals. The most abundant components were: nopol (23.0%), megastigma-3,7(E),9-triene (9.0%), curlone (7.0%) and ( 4E)-2-methyl-4-octenal (5.9%). The percentage of α-curcume, α-zingiberene and βsesquiphellandrene were 0.9, 1.6 and 1.9%, respectively. The polyphenol, flavonoid and ascorbic acid values were 3,270.30 ±0.00 µgmg -1 GAE, 51.79±0.00 µgmg -1 QE and 51.48±0.03 µgmg -1 AAE, respectively. The rhizome extract of C. longa contained some phenolic compounds such as o-guaiacol (1.5%), p-vinylguaiacol (2.0%) and ferulic acid methyl ester (1.5%). The rhizome extract showed very low IC50 and therefore high AAI with Galvinoxyl (25.0 µgml -1 and 1.68) and DPPH (5.0 µgml -1 and 8.0). The total antioxidant capacity value was 1,173.08±0.00 µgmg -1 AAE. The rhizome extract also gave high anti-arthritic protein denaturation value between 86.82-69.32%. The extract was active against all the tested bacteria isolates showing high zones of inhibition (10.0-24.0 mm). The studies provide important information for efficient and effective uses of rhizome of C. longa for nutritional and therapeutic purposes.

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“…Absorbance of all samples was read at 517 nm. DPPH radical scavenging assay was calculated by the following formula [16]: % Antioxidant activity = {(absorbance at blank) − (absorbance at test)/ (absorbance at blank)}×100…”

Section: 1-diphenyl-2-picrylhydrazyl (Dpph) Radical Scavenging Assaymentioning

confidence: 99%

Biological Activities of Garcinia Mangostana

Lalitha¹,

P²,

T³

et al. 2017

Asian J Pharm Clin Res

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Objective: The aim of the present study was to investigate in vitro antibacterial, antifungal, and antioxidant activities of different solvent extracts of Garcinia mangostana leaves. Methods:The powdered leaf was subjected to sequential extraction using hexane, ethyl acetate (EA), and methanol. The extracts were subjected to quantitative and qualitative phytochemical analysis, antimicrobial, and antioxidant activities. The best solvent extract was subjected to gas chromatography-mass spectrometry (GC-MS) analysis. Results:The highest activity was recorded in EA extract which was subjected to GC-MS analysis revealing the presence of squalene (17.09%). Conclusion:From this present study, we conclude that EA is the best solvent for extracting antimicrobial and antioxidant compounds from the leaves of G. mangostana.

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A Comparative Study on the Effect of Solvents on the Phytochemical Profile and Biological Potential of Ormocarpum Cochinchinense Auct. Non (Lour.) Merrill

Cited by 8 publications

References 15 publications

Snailicidal, antimicrobial, antioxidant and anticancer activities of Beauveria bassiana, Metarhizium anisopliae and Paecilomyces lilacinus fungal extracts

Snailicidal, antimicrobial, antioxidant and anticancer activities of Beauveria bassiana, Metarhizium anisopliae and Paecilomyces lilacinus fungal extracts

Secondary Metabolites, Pharmacognostic and Therapeutic Activities of the Rhizome Extract of Curcuma longa Grown in South-West, Nigeria

Biological Activities of Garcinia Mangostana

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