A comparative study on the lipid peroxidation and total antioxidant status in patients with and without varicose veins

Shetty, Gaurav B.; Ballal, Rajesh; Kumari, N. Suchetha; Ullal, Harshini

doi:10.18203/2320-6012.ijrms20162930

Cited by 1 publication

(2 citation statements)

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“…Research findings studying the Gpx and GST, and thus GSH levels in tissue homogenates of VVs and their association with the disease are controversial. 6,26,31,32 In our study, CAT levels were found to be higher than the control group. In the context of the study, MDA and CAT levels were found to be higher than control group and SOD, GPx and GST levels were found to be lower than the control group.…”

Section: Discussioncontrasting

confidence: 41%

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Effects of the oxidative stress and genetic changes in varicose vein patients

Sarıbal

Kanber²,

Hocaoglu-Emre

et al. 2018

Phlebology

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Background Etiology of the varicose veins is still partly known. It has been proposed that varicose veins formation might be a cause of the oxidative stress and/or cause from genetical reasons. Method The levels of antioxidant defense system enzymes, superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, and an oxidative stress indicator, malondialdehyde, were measured in saphenous vein samples of varicose veins patients. Additionally, genetical polymorphism of glutathione S-transferase theta-1 has been studied. Result In this study, measurements revealed significant increase in catalase and malondialdehyde levels in the patient group, whereas superoxide dismutase and glutathione peroxidase and glutathione S-transferase enzyme activity and comparison of the null mutation frequency in the glutathione S-transferase theta-1 gene did not show a statistically significant difference. Conclusion We propose that the increase in catalase and malondialdehyde activities in our patient group may be related to each other. Increase in catalase levels, an antioxidant enzyme might be a compensatory response to the increase in malondialdehyde levels, an oxidative molecule.

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Section: Discussioncontrasting

confidence: 41%

“…Research findings studying the Gpx and GST, and thus GSH levels in tissue homogenates of VVs and their association with the disease are controversial. 6,26,31,32…”

Section: Discussionmentioning

confidence: 99%