A comparative study on wound‐healing in neonatal and adult mouse epidermis in vivo

Abstract

Abstract. A cut made into the back skin of either newborn or adult mice evokes, at both ages, a hyperproliferative response in the epidermis. Differences in the reaction of neonatal as compared with adult epidermis are found in the spatial distribution of proliferative activity as well as in its time course. The response in adult mouse epidermis is inhibited by local application of indomethacin, whereas the response of the newborn epidermis is not.

Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis

“…Since expression of the transgene is still detectable in adult epidermis (data not shown), the mechanism responsible for normalizing the eect of the ML.myc2 transgene is most likely the same mechanism that is responsible for the transition of highly proliferative neonatal skin to adult skin (Bertsch and Marks, 1982). This also re¯ects the homeostatic mechanisms that compensate for the imbalance in proliferation induced by oncogenes.…”

Development of gene-switch transgenic mice that inducibly express transforming growth factor β1 in the epidermis

“…Although TGF␤1 transgene induction resulted in decreased BrdUrd labeling and aberrant K6 expression, the thickness of the epidermis was not significantly changed. It is possible that the proliferation rate of the epidermis is gradually decreased from neonates to adults (22); thus, TGF␤1 may induce obvious morphological changes under conditions of epidermal hyperproliferation. To test this hypothesis, 10 g of PMA was topically applied to back skin of adult bigenic TGF␤1 mice.…”