A comparison between 11C-methionine PET/CT and MIBI SPECT/CT for localization of parathyroid adenomas/hyperplasia

Hayakawa, Nobuyuki; Nakamoto, Yuji; Kurihara, Kensuke; Yasoda, Akihiro; Kanamoto, Naotetsu; Miura, Masako; Inagaki, Nobuya; Togashi, Kaori

doi:10.1097/mnm.0000000000000216

Cited by 37 publications

(30 citation statements)

References 19 publications

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“…In the largest study included in our meta-analysis, overall sensitivity was 83 %, versus 33 % for hyperplastic glands [17]. Hyperplastic glands are often smaller in size and weigh less than adenomas, both factors that have previously been associated with decreased sensitivity [14]. This might also be a contributing reason as to why performance is lower in patients with persistent pHPT after previous parathyroid surgery.…”

Section: Discussionmentioning

confidence: 98%

Use of PET tracers for parathyroid localization: a systematic review and meta-analysis

Kluijfhout

Pasternak

Drake

et al. 2016

Langenbecks Arch Surg

108

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Purpose The great spatial and temporal resolution of positron emission tomography might provide the answer for patients with primary hyperparathyroidism (pHPT) and non-localized parathyroid glands. We performed a systematic review of the evidence regarding all investigated tracers. Methods A study was considered eligible when the following criteria were met: (1) adults ≥17 years old with non-familial pHPT, (2) evaluation of at least one PET isotope, and (3) Of the other investigated tracers, 18-FCH seems the most promising with high diagnostic performance. Conclusions The results of our meta-analysis show that 11C-MET PET has an overall good sensitivity and PPVand may be considered a reliable second-line imaging modality to enable minimally invasive parathyroidectomy. Our literature review suggests that 18F-FCH PET may produce even greater accuracy and should be further investigated using both low-dose CT and MRI for anatomical correlation.

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Section: Discussionmentioning

confidence: 98%

Use of PET tracers for parathyroid localization: a systematic review and meta-analysis

Kluijfhout

Pasternak

Drake

et al. 2016

Langenbecks Arch Surg

108

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“…In our case the 99m Tc sestamibi scan did not assist in the diagnosis prob-ably due to its cystic morphology. The 18F-fluorocholine PET/CT and the 11C-methionine PET/CT have shown excellent sensitivity for parathyroid lesions and could be of diagnostic assistance when available [14,15].…”

Section: Resultsmentioning

confidence: 99%

Intrathyroidal parathyroid adenoma mimicking thyroid cancer

et al. 2020

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Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia; patients are usually asymptomatic and the cause in 80-85% of cases is a single parathyroid adenoma (PA). Parathyroid adenomas arise from clonal expansion of tumor cells and may be located either posteriorly to the thyroid lobes or in ectopic sites. The incidence of intrathyroidal PAs varies from 1% to 6% and although uncommon, they pose certain diagnostic difficulties which may complicate treatment. The identification of the adenoma requires a combination of clinical evidence, imaging information and cytological findings due to the challenging distinction between thyroid and parathyroid lesions. We present the case of a patient with a large, partially cystic intrathyroidal parathyroid adenoma which was initially identified as a malignant thyroid nodule. We discuss the caveats that present in these rare cases and the important clinical and histological features that aid in the final diagnosis. In the case of our patient the cytological similarities between thyroid malignant cells and parathyroid cells, in combination with the negative sestamibi scan, resulted in a more invasive surgery than that a single parathyroid adenoma would require. Clinicians need to be vigilant in terms of the similarities between parathyroid and thyroid cytology in order to provide optimal patient care in these rare cases.

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“…[ 11 ] However, some parathyroid adenomas may show rapid washout or do not have any MIBI uptake in such cases 11 C-Met PET-CT scanning was found to have a sensitivity of 83%, a specificity of 100% and an accuracy of 88% in successfully locating parathyroid adenomas. [ 3 12 13 ]…”

Section: Discussionmentioning

confidence: 99%

¹¹ C-Methionine positron emission tomography-computed tomography in localization of methoxyisobutyl isonitrile negative ectopic parathyroid adenoma

et al. 2016

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Primary hyperparathyroidism is caused by parathyroid adenomas in 85% of the cases. Since parathyroid adenomas are known for their ectopic location, presurgical localization of the suspected site of adenoma is desirable. However, current imaging modalities are not always successful in localizing ectopic parathyroid adenomas. The aim of this case report is to show that 11C-methionine positron emission tomography could accurately localize ectopic parathyroid adenomas in patients in whom conventional imaging had failed or is inconclusive.

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A comparison between 11C-methionine PET/CT and MIBI SPECT/CT for localization of parathyroid adenomas/hyperplasia

Abstract: The sensitivities of MET PET/CT and MIBI SPECT/CT were comparable. MET PET/CT has a complementary role in localizing parathyroid adenomas/hyperplasia when MIBI SPECT/CT is inconclusive.

Cited by 37 publications

References 19 publications

Use of PET tracers for parathyroid localization: a systematic review and meta-analysis

Use of PET tracers for parathyroid localization: a systematic review and meta-analysis

Intrathyroidal parathyroid adenoma mimicking thyroid cancer

¹¹ C-Methionine positron emission tomography-computed tomography in localization of methoxyisobutyl isonitrile negative ectopic parathyroid adenoma

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A comparison between 11C-methionine PET/CT and MIBI SPECT/CT for localization of parathyroid adenomas/hyperplasia

Abstract: The sensitivities of MET PET/CT and MIBI SPECT/CT were comparable. MET PET/CT has a complementary role in localizing parathyroid adenomas/hyperplasia when MIBI SPECT/CT is inconclusive.

Cited by 37 publications

References 19 publications

Use of PET tracers for parathyroid localization: a systematic review and meta-analysis

Use of PET tracers for parathyroid localization: a systematic review and meta-analysis

Intrathyroidal parathyroid adenoma mimicking thyroid cancer

11 C-Methionine positron emission tomography-computed tomography in localization of methoxyisobutyl isonitrile negative ectopic parathyroid adenoma

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¹¹ C-Methionine positron emission tomography-computed tomography in localization of methoxyisobutyl isonitrile negative ectopic parathyroid adenoma