A comparison of amlodipine with enalapril in the treatment of isolated systolic hypertension.

Webster, J; Fowler, Gillian; Jeffers, T A; Lyons, Declan; Witte, K.; W, Crichton; Wickham, E A; Sanghera, S; Cornish, Richard D.; Petrie, J. C.

doi:10.1111/j.1365-2125.1993.tb04176.x

Cited by 16 publications

(3 citation statements)

References 31 publications

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“…The most common adverse effects reported in human beings treated with amlodipine are oedema, dizziness, fatigue, and heart palpitations (Osterloh 1991, Webster and others 1993, Burges and Moisey 1994, Weir 2003). Systemic hypotension is a rare but reported complication in cats, and gingival hyperplasia has been described in dogs treated with amlodipine over several months (Henik and others 1997, Thomason and others 2009).…”

Section: Discussionmentioning

confidence: 99%

Occurrence of systemic hypertension in dogs with acute kidney injury and treatment with amlodipine besylate

Geigy

Schweighauser

Doherr

et al. 2011

Journal of Small Animal Practice

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Section: Discussionmentioning

confidence: 99%

Occurrence of systemic hypertension in dogs with acute kidney injury and treatment with amlodipine besylate

Geigy

Schweighauser

Doherr

et al. 2011

Journal of Small Animal Practice

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“…There was no first-dose hypotension with spirapril 3mg, but most patients required a dosage increase to 6mg daily, which is still a relatively low dosage. In another study, [88] in patients ranging in age from 45 to 76 years, enalapril and amlodipine had comparable effects in controlling isolated systolic hypertension. Elderly patients in that study were given enalapril 2.5mg as the starting dose.…”

Section: Isolated Systolic Hypertensionmentioning

confidence: 82%

Optimal Dosage of ACE Inhibitors in Older Patients

Tomlinson

1996

Drugs & Aging

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Despite having lower levels of plasma renin activity than younger individuals, elderly patients with hypertension respond well to ACE inhibitors and the drugs have few adverse effects. Plasma concentrations of the active ACE inhibitor are generally higher in the elderly because of decreased renal clearance. These altered pharmacokinetics, combined with impairment of cardiovascular reflexes and the increasing prevalence of heart failure and renal impairment with age, render elderly patients more susceptible to first-dose hypotension. Although many studies have shown that standard dosages are well tolerated it is safer to use lower initial dosages of ACE inhibitors in elderly hypertensive patients because hypotensive reactions are not always predictable. The maintenance dosage may be determined more by the presence of renal disease or heart failure than by age per se. In elderly patients with heart failure, ACE inhibitors should be introduced even more cautiously, using low dosages and preferably under supervision. It may also be necessary to interrupt diuretic treatment for a few days to prevent severe hypotension. The ACE inhibitor dosage should then be titrated up to the maximum that is well tolerated, as this appears to offer the greatest benefit.

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“…Amlodipine has a particularly slow onset of action and long duration of effect (it has a plasma elimination half‐life of 30–50 h), which, unlike other dihydropyridines, allows a single daily dosage regimen [17,18]. Amlodipine has been shown to be effective and well‐tolerated in a broad range of patient populations, including elderly patients with ISH [19–21].…”

Section: Introductionmentioning

confidence: 99%

Randomized, comparative, double‐blind study of amlodipine vs. nicardipine as a treatment of isolated systolic hypertension in the elderly

Mounier‐Véhier

Jaboureck

Emeriau

et al. 2002

Fundamemntal Clinical Pharma

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A 90-day, multicenter, randomized, double-blind, parallel-group study was conducted to compare the efficacy of amlodipine (once a day) with nicardipine (two to three times a day), in the treatment of isolated systolic hypertension (ISH) in the elderly. Patients (n = 133) aged > or = 60 years, with ISH were randomized to receive either amlodipine 5 mg/day, or nicardipine 60 mg/day (titrated if necessary to 10 mg/day and 100 mg/day, respectively) for 90 days. Efficacy was assessed by measuring office blood pressure (BP), and 24-h ambulatory blood pressure monitoring (ABPM). The two treatments substantially and comparably reduced office systolic blood pressure (SBP) and pulse pressure (PP), and also produced a slight decrease in diastolic blood pressure (DBP). Amlodipine reduced SBP, as assessed by ABPM, to a significantly greater extent than nicardipine. Both treatments were well-tolerated. The sustained effect of amlodipine, compared with nicardipine, was reflected in its significantly greater antihypertensive activity, particularly during the nocturnal period, as assessed by ABPM. The study demonstrates that once a day dose of amlodipine is an effective antihypertensive treatment for elderly ISH patients.

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A comparison of amlodipine with enalapril in the treatment of isolated systolic hypertension.

Cited by 16 publications

References 31 publications

Occurrence of systemic hypertension in dogs with acute kidney injury and treatment with amlodipine besylate

Occurrence of systemic hypertension in dogs with acute kidney injury and treatment with amlodipine besylate

Optimal Dosage of ACE Inhibitors in Older Patients

Randomized, comparative, double‐blind study of amlodipine vs. nicardipine as a treatment of isolated systolic hypertension in the elderly

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