A Comparison of Cabergoline and Bromocriptine in the Treatment of Hyperprolactinemic Amenorrhea

Pediatric sellar tumors: diagnostic procedures and management

“…Treatment with dopamine agonists is effective in normalizing PRL levels and shrinking the tumor mass in the majority of adult patients with prolactinoma. 16,45,56 In children and adolescents, bromocriptine has been used successfully by several investigators to decrease tumor volume. 9 Quinagolide and cabergoline are two selective dopamine receptor subtype-2 agonists that have also been reported to be effective in reducing PRL secretion and tumor size in adult patients with prolactinoma, even in those previously shown to be poorly responsive to or intolerant of bromocriptine.…”

“…16,45 Its convenient weekly administration also makes it an excellent therapeutic alternative in children with prolactinomas. 56 …”

Managing anovulatory infertility

“…Safety of the drugs in pregnancy is therefore an important consideration. Compared with bromocriptine, cabergoline appears more effective in increasing pregnancy rates, and causes fewer and less severe gastrointestinal symptoms,18 but there is less experience of its use in pregnancy. The SPC for cabergoline advises discontinuing the drug 1 month prior to intended conception.…”

New drugs for hyperprolactinaemia

“…In over 90% of those with a macroprolactinoma, the tumour shrunk by at least 25%. In a large, randomised study comparing cabergoline (0.5-1mg weekly) with bromocriptine (2.5-5mg twice daily) given for 6 months in 459 patients, cabergoline was more effective than bromocriptine in restoring normal prolactin levels (83% vs 59%) and ovulatory cycles (72% vs 52%) 9. Cabergoline has also been compared with bromocriptine for the prevention of puerperal lactation.…”

“…Cabergoline appears to cause fewer and milder unwanted effects than twice daily bromocriptine, particularly less nausea and vomiting 9 , 10. Comparisons of cabergoline with once daily bromocriptine are not published.…”