A comparison of chemical composition, bioactive components and antioxidant activity of natural and cultured Cordyceps sinensis

Wang, Junqiao; Kan, Lijiao; Nie, Shaoping; Chen, Haihong; Cui, Steve W.; Phillips, Aled Owain; Phillips, Glyn O.; Li, Yajing; Xie, Mingyong

doi:10.1016/j.lwt.2015.03.109

Cited by 83 publications

(46 citation statements)

References 30 publications

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“…It was remarkable that various compounds were present in high amounts in some locations but lower or absent in others. Such differences, depending on the sampling location, have been reported by other authors (Rastija et al, ; Wang et al, ). For example, gallic acid and caffeic acid were present in all studied regions.…”

Section: Resultssupporting

confidence: 72%

“…It can be concluded from the results that the sample from Redeyef was richer in phenolic compounds than those from Tabarka and Nasrallah. Reports have shown that the variability in the types and concentrations of phenolic compounds between species from different geographic origins can be related to several factors such as climate, temperature, soil composition and humidity (Tlili et al, ; Wang et al, ). Therefore, further studies will be necessary to investigate the effect of above parameters on the chemical composition of A. spinosus .…”

Section: Resultsmentioning

confidence: 99%

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Characterization ofAmaranthus spinosuscollected from different regions: Phytochemical and biological properties

et al. 2017

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Amaranth is extensively cultivated as a green leafy vegetable and grain crop in many countries. The nutritional, chemical composition, antioxidant activity, and hemolytic potential of Amaranthus spinosus leaves collected from different locations in Tunisia were evaluated and compared. Leaves showed high levels of protein, carbohydrate, crude fiber, and ash. The leaves presented high contents in macro (K, Mg, Ca, and Na) and micronutrients (Fe, Zn, and Mn). Total phenolic and flavonoid contents ranged between 6.6 to 19.6 mg GAE/g DW and 4.07 to 10.48 mg CAE/g DW, respectively. The major compound in the essential oil was found to be α ‐thujone. The plant exhibited high antioxidant activity with EC50 values ranging from 25.55 to 54.58 μg/mL for DPPH radical scavenging capacity and 37.54–116.72 μg/mL for H2O2 scavenging activity, respectively. Moreover, A. spinosus leaves have the potential to protect red blood cells from hemolysis. Practical applications The results showed that A. spinosus could be a new source of nutrients and antioxidants and its use in human diet, nutraceutical development, and therapy is encouraged. Especially, it could be used to mitigate the risk of various diseases including cardiovascular, neurological, cancer, and Alzheimer's which are caused by reactive oxygen species (like H2O2).

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Section: Resultssupporting

confidence: 72%

Section: Resultsmentioning

confidence: 99%

Characterization ofAmaranthus spinosuscollected from different regions: Phytochemical and biological properties

et al. 2017

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“…sinensis although the type and quantity of bioactive compounds synthesized by wild O . sinensis may differ from those by the cultured mycelium (Singh et al ., ; Wang et al ., ; Zhou et al ., ). For example, the levels of polysaccharide, adenine and adenosine in cultured sample amounted to 10.43%, 0.50 mg/g and 2.61 mg/g, respectively, considerably higher than the natural ones (8.90%, 0.11 mg/g and 0.96 mg/g) (Wang et al ., ).…”

Section: Taxonomy Biology Distribution and Artificial Cultures Of Omentioning

confidence: 99%

“…A recent study by Wang et al . () has demonstrated that the artificially cultured O . sinensis produced higher levels of polysaccharide, adenine and adenosine than those of the natural ones.…”

Section: Bioactive Compounds Of O Sinensismentioning

confidence: 99%

“…sinensis although the type and quantity of bioactive compounds synthesized by wild O . sinensis may differ from those by the cultured mycelium (Singh et al ., ; Wang et al ., ; Zhou et al ., ). These findings will not only reduce the pressure on natural resources of the species but also will increase the usage of this fungus in health treatment.…”

Section: Introductionmentioning

confidence: 99%

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The Mechanisms of Pharmacological Activities ofOphiocordyceps sinensisFungi

Huang

Chen

et al. 2016

Phytother. Res.

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The entomopathogenic fungus Ophiocordyceps sinensis, formerly known as Cordyceps sinensis, has long been used as a traditional Chinese medicine for the treatment of many illnesses. In recent years its usage has increased dramatically because of the improvement of people's living standard and the emphasis on health. Such demands have resulted in over-harvesting of this fungus in the wild. Fortunately, scientists have demonstrated that artificially cultured and fermented mycelial products of O. sinensis have similar pharmacological activities to wild O. sinensis. The availability of laboratory cultures will likely to further expand its usage for the treatment of various illnesses. In this review, we summarize recent results on the pharmacological activities of the components of O. sinensis and their putative mechanisms of actions. Copyright © 2016 John Wiley & Sons, Ltd.

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Metabolite profiling and antioxidant capacity of natural Ophiocordyceps gracilis and its cultures using LC‐MS/MS‐based metabolomics: Comparison with Ophiocordyceps sinensis

Wang,

Tong,

Yang

et al. 2023

Phytochemical Analysis

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IntroductionOphiocordyceps gracilis is an entomopathogenic fungus and a precious traditional Chinese medicine with similar medicinal properties to Ophiocordyceps sinensis. However, information on the metabolite profiles of natural O. gracilis and its cultures is lacking, which limits their utilization.ObjectiveThe metabolic variations and antioxidant activities of O. gracilis cultures and natural O. gracilis were analyzed to evaluate the nutritional and medicinal value of O. gracilis and its cultures.MethodThe metabolite profiles of O. gracilis cultures (fruiting bodies and aerial mycelia), natural O. gracilis, and natural O. sinensis were compared by LC‐MS/MS coupled with multivariate data analysis. Furthermore, their antioxidant activities were evaluated based on their DPPH•, ABTS•+, and •OH scavenging abilities.ResultsA total of 612 metabolites were identified, and the metabolic compositions of the four Cordyceps samples were similar, with differences observed in the levels of some metabolites. There were 126 differential metabolites between natural O. gracilis and natural O. sinensis, among which fatty acids, carbohydrates, and secondary metabolites are predominant in natural O. gracilis. Furthermore, 116 differential metabolites between O. gracilis cultures and natural Cordyceps were identified, with generally higher levels in O. gracilis cultures than in natural Cordyceps. O. gracilis cultivated fruiting bodies exhibited the strongest antioxidant capacity among Cordyceps samples. Additionally, 46 primary and 24 secondary differential metabolites contribute to antioxidant activities.ConclusionThis study provides a reference for the application of natural O. gracilis and its cultures in functional food and medicine from the perspective of metabolites and antioxidant capacity.

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A comparison of chemical composition, bioactive components and antioxidant activity of natural and cultured Cordyceps sinensis

Cited by 83 publications

References 30 publications

Characterization ofAmaranthus spinosuscollected from different regions: Phytochemical and biological properties

Characterization ofAmaranthus spinosuscollected from different regions: Phytochemical and biological properties

The Mechanisms of Pharmacological Activities ofOphiocordyceps sinensisFungi

Metabolite profiling and antioxidant capacity of natural Ophiocordyceps gracilis and its cultures using LC‐MS/MS‐based metabolomics: Comparison with Ophiocordyceps sinensis

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