Rank-based procedures for linear models generalize the simple Wilcoxon rank tests in the simple location models, inheriting their robustness and high efficiency properties.Given a general linear model, these rank-based procedures form a complete analysis, including estimation, conjidence, and multiple comparison procedures, and tests of general linear hypotheses. In this article, these ranked-based procedures are reviewed in the context of pharmaceutical science data. Examples involving ANOVA-and ANCOVAtype designs are considered in some detail. We further present a Web-based interface incorporating the statistical software R and RGLM for the computation of these procedures. As discussed, the user need only visit our Web site to compute these procedures.Taken together these rank-based procedures offer the user an efJicient and robust alternative to standard least squares procedures for linear models.