A Comparison of Dextran and Oxypolygelatin in the Treatment of Hemorrhagic Hypotension

Abstract

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

Treatment of Shock with Dextrans and Gelatins

“…The conclusion to be drawn from these findings -which are in essential agreement with the earlier American studies [82,167] -is that if definitive treatment is delayed for prolonged periods of time in peace or war, only a sufficient total dose of water, salt and colloids covering the needs of the whole extracellular space will carry the severely injured patient through, irrespective of the kind of colloid available for initial emergency treatment. The critical range of volume replacement in which the greater potency of clinical dextran might be relevant for initial emergency treatment does at any rate lie below y3 replacement of losses equalling half the normal blood volume, i.e.…”

“…American and European authors [5,6,24,82,84,87,127,167] agree that clinical dextran leads the gelatins by 5 to 10% of blood volume when equal volumes are infused for the treatment of deficits up to and including half the normal blood volume. Clinical dextran is also more potent than plasma, the effect of which is almost identical with that of the gelatins [82,173].…”

“…With the 24-hour survival rate as a criterion, Parkins and co workers [160,161] and the US Army group of Gropper, Raisz and Pulaski [82,167] failed to establish any differences in the therapeutic effects of the dextrans and gelatins available at the time of the Korean War, despite the somewhat greater potency of the dextrans employed. These studies have been repeated in the rabbit in our laboratory with the commercial preparations available in Europe to-day and under more severe conditions than those employed by the American investigators 17 years ago [124,126].…”

Treatment of Shock with Dextrans and Gelatins

“…With the 24-hour survival rate as a criterion, PARKINS and coworkers [160, 1611 and the US Army group of GROPPER, RAISZ and PULASKI [82,167] failed t o establish any differences in the therapeutic effects of the dextrans and gelatins available at the time of the Korean War, despite the somewhat greater potency of the dextrans employed. These studies have been repeated in the rabbit in our laboratory with the commercial preparations available in Europe to-day and under more severe conditions than those employed by the American investigators 17 years ago [124, 1261.…”