A comparison of DRO to movement suppression time-out and DRO with two self-injurious and aggressive mentally retarded adults

Matson, Johnny L.; Keyes, Joseph B.

doi:10.1016/0891-4222(90)90008-v

Cited by 18 publications

(4 citation statements)

References 7 publications

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“…It is reported to occur in between 7 and 30% of neurodevelopmentally delayed individuals, especially those with autism [Green, 1967;MacKay et al,1974;Sandman and Barron, 1992;Schroeder et al, 1978]. The most influential explanations of SIB have been behavioral (e.g., attention seeking; escape/avoidance), and many interventions were effective without consideration of possible biological mechanisms [Iwata et al, 1982;Matson and Taras, 1989;Matson and Keyes, 1990;Rincover and Devaney, 1982;Rincover and Koegel, 1975;Romanczyk and Goren, 1975]. Understanding putative biological mechanisms provides a basis for rational pharmacological treatment strategies.…”

Section: Self-injurious Behavior (Sib) and Proopiomelanocortin (Pomc)mentioning

confidence: 99%

Proopiomelanocortin (POMC) disregulation and response to opiate blockers

Sandman

Spence

Smith

1999

Ment. Retard. Dev. Disabil. Res. Rev.

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Autism is a collection of disorders or subtypes with distinctive or prominent phenotypes and genotypes. The study of adults with autism offers a unique opportunity to examine its phenotypic diversity. Recent evidence has identified disturbances in specific neurochemical systems that are associated with primary autistic symptoms. Establishing biological markers, such as specific neurochemical disturbances, not only confers greater precision in phenotyping individuals but also provides the basis for rational intervention. Our initial studies in adult individuals exhibiting self-injurious behavior (SIB) generated evidence that the proopiomelanocortin (POMC) system, specifically the endogenous opioid system, may be disregulated in subgroups of autistic patients. These findings, corroborated in at least 15 other laboratories, indicated that treatment with an opiate blocker, naltrexone (NTX), reduced SIB in 30-70% of individuals observed. However, the effects of NTX on SIB were not simple. We and others have found that concentration of plasma POMC fragments, specifically opioid fragments, contributed to the symptoms of autism and to the response to treatment. Uncoupling of the release of POMC products predicted the efficacy of NTX treatment on the expression of SIB. Uncoupling of POMC fragments among autistic and SIB patients suggested a basic, underlying defect, perhaps in the POMC gene. The findings of a maternal influence on the C-terminal BE fragment among individuals with autism (Leboyer et al. [1999] Soc Biol Psychiatry 45:158-163) and our preliminary findings, reported here, of a mutation in the opioid region of the POMC gene in an autistic individual, were consistent with the prospect that a subgroup of patients will be identified who share a POMC genetic defect.1999 Wiley-Liss, Inc.

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Section: Self-injurious Behavior (Sib) and Proopiomelanocortin (Pomc)mentioning

confidence: 99%

Proopiomelanocortin (POMC) disregulation and response to opiate blockers

Sandman

Spence

Smith

1999

Ment. Retard. Dev. Disabil. Res. Rev.

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“…An impressive body of research accumulated over 30 years has found TO effective with a variety of behaviors and with various child and adolescent populations. For example, TO has been used successfully with children with developmental delays (Mace & Heller, 1990; Matson & Keyes, 1990; Olmi, Sevier, & Nastasi, 1997), adolescent psychiatric patients (Crespi, 1988), oppositional and aggressive children (Jones, Sloane, & Roberts, 1992; Roberts, 1988; Roberts & Powers, 1990), and nonclinical populations (Gardner, Forehand, & Roberts, 1976).…”

mentioning

confidence: 99%

The sequential introduction of compliance training components with elementary-aged children in general education classroom settings.

Ford¹,

Olmi²,

Edwards³

et al. 2001

School Psychology Quarterly

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“…Recent examples include a review of the treatment of sexual deviancy in which Foxx et al (1986) discuss one study in which Differential Reinforcement of Other Behaviour Schedule (DRO) alone was effective as a treatment of exposure, but two others in which DRO was effective for the treatment of masturbation only when combined with over-correction. Matson and Keyes (1990) found that neither DRO alone nor combined with verbal reprimand was effective in reducing selfinjury and aggressive behaviours, but that these were reduced by the addition of brief (1 minute) movement suppression time out, in one case this effect being maintained over eight months. McGreevy and Arthur (1987) used a combined Differential Reinforcement of Incompatible Behaviour Schedule (DRI)/punishment programme to decrease self-biting in a two year old with Lesch-Nyhan syndrome.…”

Section: Non-aversive Methodsmentioning

confidence: 91%

Recent Advances in Work with People with Learning Difficulties

Carr

1991

Behav. Psychother.

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“Of all the contributions made by psychologists to the education and training of the mentally retarded in recent years, pride of place must surely be accorded to behaviour modification” (Clarke and Clarke, 1987). This is a significant claim and one that may be disputed by those who work in other areas (as indeed do the Clarkes themselves) but there is little doubt that behavioural methods have made a major contribution to the teaching and management of people with learning difficulties. This paper will divide the, necessarily selective, review of recent research into two main areas: first, that concerned with skill development and second, that concerned with behaviour reduction and the management of what has become known as Challenging Behaviour.

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A comparison of DRO to movement suppression time-out and DRO with two self-injurious and aggressive mentally retarded adults

Cited by 18 publications

References 7 publications

Proopiomelanocortin (POMC) disregulation and response to opiate blockers

Proopiomelanocortin (POMC) disregulation and response to opiate blockers

The sequential introduction of compliance training components with elementary-aged children in general education classroom settings.

Recent Advances in Work with People with Learning Difficulties

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