A comparison of elderly and adult multiple organ dysfunction syndrome in the rat model

Zhu, Qinglei; Qian, Xiaoshun; Wang, Shiwen; Yin, Tong; Yang, Jie; Qin, Xue; Xu, Bin

doi:10.1016/j.exger.2006.05.010

Cited by 11 publications

(6 citation statements)

References 19 publications

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“…The lungs are the first and primary target organ to be affected in the postinjury period, and lung injury caused by posttraumatic inflammatory reactions increases mortality risk [ 23 , 31 , 32 ]. Recently, a number of studies have reported that the elderly possess a reduced physiological reserve and are more vulnerable to posttraumatic inflammatory reactions; even minor trauma can cause severe autodestructive proinflammatory cytokine release that is uncompensated by anti-inflammatory mediators [ 33 – 35 ]. This is consistent with our experimental results.…”

Section: Discussionmentioning

confidence: 99%

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The Immediate Intramedullary Nailing Surgery Increased the Mitochondrial DNA Release That Aggravated Systemic Inflammatory Response and Lung Injury Induced by Elderly Hip Fracture

Gan

Zhong

Zhang

et al. 2015

Mediators of Inflammation

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Conventional concept suggests that immediate surgery is the optimal choice for elderly hip fracture patients; however, few studies focus on the adverse effect of immediate surgery. This study aims to examine the adverse effect of immediate surgery, as well as to explore the meaning of mtDNA release after trauma. In the experiment, elderly rats, respectively, received hip fracture operations or hip fracture plus intramedullary nail surgery. After fracture operations, the serum mtDNA levels as well as the related indicators of systemic inflammatory response and lung injury significantly increased in the rats. After immediate surgery, the above variables were further increased. The serum mtDNA levels were significantly related with the serum cytokine (TNF-α and IL-10) levels and pulmonary histological score. In order to identify the meaning of mtDNA release following hip fracture, the elderly rats received injections with mtDNA. After treatment, the related indicators of systemic inflammatory response and lung injury significantly increased in the rats. These results demonstrated that the immediate surgery increased the mtDNA release that could aggravate systemic inflammatory response and lung injury induced by elderly hip fracture; serum mtDNA might serve as a potential biomarker of systemic inflammatory response and lung injury following elderly hip fracture.

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Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported that elderly hip fracture induces a systemic inflammatory response and lung injury and increases the incidence of complications and mortality in elderly patients [ 1 , 9 , 11 , 30 , 32 , 35 ]. Any neglect or misdiagnosis of this condition may produce disastrous results.…”

Section: Discussionmentioning

confidence: 99%

The Immediate Intramedullary Nailing Surgery Increased the Mitochondrial DNA Release That Aggravated Systemic Inflammatory Response and Lung Injury Induced by Elderly Hip Fracture

Gan

Zhong

Zhang

et al. 2015

Mediators of Inflammation

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“…In contrast, zymosan, a component of yeast cell walls comprised mainly of β‐glucan and mannan, is a specific ligand for TLR2/6 and is capable of inducing inflammation that mimics a non‐bacterial inflammatory response 10–12 . Zymosan can activate macrophages, monocytes and leucocytes to stimulate the release of inflammatory products, including tumour necrosis factor (TNF)‐α, interleukin (IL)‐8 and hydrogen peroxide, which results in systemic inflammation 13–16 . It remains unknown whether maternal non‐bacterial inflammatory stress can cause hypertension in adult offspring.…”

Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Zymosan Results in Hypertension in Adult Offspring Rats

Liao

Wei

et al. 2008

Clin Exp Pharma Physio

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1. Events in utero appear to have a significant role in the development of cardiovascular dysfunction in adulthood. In the present study, we evaluated the effects of prenatal exposure to zymosan, a non-infectious and non-bacterial agent capable of inducing inflammation, on mean systolic arterial pressure (MSAP) in rat offspring at 6-66 weeks of age. 2. Pregnant rats were divided into three groups: (i) a control group, administered 0.5 mL, i.p., saline on gestation Days 8, 10 and 12; (ii) a zymosan-treated group, given 2.37 mg/kg, i.p., zymosan on gestation Days 8, 10 and 12; and (iii) a pyrrolidine dithiocarbamate (PDTC) + zymosan-treated group, which was given 100 mg/kg, i.p., PDTC 1 h before zymosan. At 6, 16, 26, 36, 56 and 66 weeks of age, MSAP was determined in rat offspring from all three groups. Serum levels of tumour necrosis factor (TNF)-alpha were determined in dams, as well as in offspring at 24 and 56 weeks of age. In addition, protein levels of nuclear factor (NF)-kappaB (p65) in the myocardium and kidney of offspring were determined at 24 weeks of age. 3. The results showed that MSAP and NF-kappaB (p65) levels in the myocardium and kidney of offspring from the zymosan-treated group were increased significantly compared with control. This increase was inhibited by concomitant treatment with PDTC. Serum TNF-alpha levels in dams exposed to zymosan and in their offspring at 56 weeks of age (but not at 24 weeks of age) were significantly increased compared with levels in the control group. Following lipopolysaccharide treatment (1 mg/kg, i.p.) of adult rat offspring at 24 weeks of age, there was a further increase in serum TNF-alpha levels in offspring in the zymosan-treated group compared with the other two groups. 4. The findings of the present study suggest that non-bacterial inflammation during gestation can lead to hypertension in offspring and that NF-kappaB signalling may play a critical role in this process.

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“…O'Mahony et al found that, in the case of mechanical ventilation, the presence of endotoxin, even without acute lung injury, could increase the generation of lung pro-inflammatory cytokines, promoting damage to the lungs and other organs [23]. For this reason, Zhu et al came to consider the lung to be the trigger organ for MODS [24].…”

Section: Activation Of Inflammatory Pathwaysmentioning

confidence: 99%

Severe Acute Mountain Sickness Complicated by Multiple Organ Dysfunction Syndrome

Zhou¹

2012

Emergency Medicine

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A comparison of elderly and adult multiple organ dysfunction syndrome in the rat model

Cited by 11 publications

References 19 publications

The Immediate Intramedullary Nailing Surgery Increased the Mitochondrial DNA Release That Aggravated Systemic Inflammatory Response and Lung Injury Induced by Elderly Hip Fracture

The Immediate Intramedullary Nailing Surgery Increased the Mitochondrial DNA Release That Aggravated Systemic Inflammatory Response and Lung Injury Induced by Elderly Hip Fracture

Prenatal Exposure to Zymosan Results in Hypertension in Adult Offspring Rats

Severe Acute Mountain Sickness Complicated by Multiple Organ Dysfunction Syndrome

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